Figure 1

Search strategies employed to identify published articles relevant to nicotine and inflammation in humans_
| Search engine | Search strategy | Number of papers returned |
|---|---|---|
| PubMed | nicotine [title] AND inflam* [title/abstract] | 490 |
| Science Direct | nicotine [title] AND inflammation [title/abstract/keywords] | 164 |
| Cochrane Library | Searched ‘nicotine’ and manually screened reported hits for relevant inflammation-related systematic reviews and meta-analyses | 1 |
| References from review articles | Relevant review articles were identified from excluded papers (n = 28). The reference lists of these reviews were screened for any further studies of interest | 10 |
| References from JTI database | Internal JTI databases were searched for additional articles of relevance | 10 |
| Additional articles identified from PubMed alerts | Daily email alerts created for nicotine [title/abstract] and searched for articles which meet the inclusion criteria and which were published between 5th April 2021 and 19th November 2021 | 1 |