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An Experimental Analytical and In Vitro Approach to Bridge Between Different Heated Tobacco Product Variants Cover

An Experimental Analytical and In Vitro Approach to Bridge Between Different Heated Tobacco Product Variants

Open Access
|Apr 2022

Figures & Tables

Figure 1

Emissions and toxicology bridging data. (a) Percentage reductions in emissions of selected TobReg9 analytes for THP variants relative to a reference cigarette. (b) Viability of human lung cells exposed to cigarette smoke and THP aerosol. (c) Viability of cells exposed to 85 puffs of aerosol from THP_base, variants, and the MRTP-approved commercial THP_benchmark. (d) Viability data for reference cigarette, THP_benchmark, THP_base and variants contextualised against total analyte yields.
Emissions and toxicology bridging data. (a) Percentage reductions in emissions of selected TobReg9 analytes for THP variants relative to a reference cigarette. (b) Viability of human lung cells exposed to cigarette smoke and THP aerosol. (c) Viability of cells exposed to 85 puffs of aerosol from THP_base, variants, and the MRTP-approved commercial THP_benchmark. (d) Viability data for reference cigarette, THP_benchmark, THP_base and variants contextualised against total analyte yields.

Figure 2

A schematic representation of a proposed future bridging process to leverage data from multiple sources.
A schematic representation of a proposed future bridging process to leverage data from multiple sources.

Test products and puffing regime_

ProductProduct code/puffing regimeProduct descriptorVariantBlend (top flavour)Product change from “Base”Change classification
Reference cigarette1R6F / HCI1Combustible referenceN/AUS BlendN/AN/A
Commercial comparatorTHS 2.2_R / HCI2THP_benchmarkTHS2.2Tobacco (Regular)N/AN/A
BaseTHP1.0_BT / HCIm3THP_baseTHP1.0Tobacco (Blended)N/AN/A
Variant 1THP1.1_RT / HCIm3THP_1THP1.1Tobacco (Rich)Change in tobacco flavour and increased nicotineMinor
Variant 2THP1.1_C / HCIm3THP_2THP1.1CitrusChange in device aesthetics and top flavourMinor
Variant 3THP1.1_S / HCIm3THP_3THP1.1SmoothChange in device aesthetics and top flavourMinor
Variant 4THP1.1_F / HCIm3THP_4THP1.1FreshChange in device aesthetics and top flavourMinor
Variant 5THP1.1_RTF / HCIm3THP_5THP1.1Tobacco (Rich)Change in device aesthetics, top flavour and foil wrapMajor4

Comparison of analyte emissions among products1_

AnalyteUnits1R6F2THP_benchmark3THP_baseTHP variant

12345
Acetaldehydeμg/consumable1859 (169)219 (31)122.6 (5.55)128.6 (7.89)131.8 (6.49)126.6 (12.62)123.6 (6.19)83.41 (3.95)
Acroleinμg/consumable148 (22)11.3 (24)1.69 (0.13)1.70 (0.19)2.10 (0.21)1.99 (0.23)1.75 (0.15)1.24 (0.08)
Benzeneμg/consumable76 (5.8)0.649 (0.074)0.06 (0.02)0.09 (0.03)0.06 (0.02)0.04 (0.01)0.07 (0.03)0.06 (0.02)
Benzo[a]pyreneng/consumable11.4 (1.7)NQ0.45 (0.15)0.31 (0.06)0.53 (0.06)0.43 (0.05)0.40 (0.05)NQ
1,3-Butadieneμg/consumable114 (4)0.294 (0.042)BDLBDLBDLBDLBDLBDL
Formaldehydeμg/consumable68.4 (3.9)5.53 (0.69)2.73 (0.96)2.38 (0.48)2.81 (1.56)2.65 (1.11)2.77 (1.22)1.51 (0.28)
NNKng/consumable208 (7)6.7 (0.6)7.46 (0.54)5.08 (0.63)10.01 (0.76)5.63 (1.18)6.46 (1.16)6.27 (0.84)
NNNng/consumable191 (8)17.2 (1.25)24.4 (1.96)16.5 (1.5)26.92 (1.72)0.04 (0.01)22.30 (3.16)13.31 (1.45)
COmg/consumable29.4 (0.6)0.532 (0.068)BDLBDLBDLBDLBDLBDL
Glycerolmg/consumable1.36 (0.05)4.63 (0.83)2.12 (0.24)1.94 (0.35)2.81 (0.49)2.25 (0.37)2.38 (0.26)3.95 (0.29)
TPMmg/consumable45.5 (2.2)10.3 (0.9)26.16 (1.49)27.12 (0.42)27.66 (1.25)26.34 (1.29)25.74 (1.84)26.11 (1.07)
Nicotinemg/consumable2.0 (0.08)1.32 (0.16)0.38 (0.03)0.38 (0.04)0.46 (0.03)0.38 (0.03)0.38 (0.02)0.79 (0.02)
TAYmg/consumable80.5317.0228.7929.5731.0729.1028.6330.94
TAYmg/puff10.072.133.603.703.883.643.583.87
TAY4mg32.1181.05306314.5329.8309.4304.3329
% reduction relative to (1R6F)%N/A93.2495.4196.3694.8297.3595.6897.07
Language: English
Page range: 1 - 9
Submitted on: Nov 16, 2021
Accepted on: Feb 17, 2022
Published on: Apr 16, 2022
Published by: Institut für Tabakforschung GmbH
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2022 Tomasz Jaunky, David Thorne, Andrew Baxter, Simone Hadley, Justin Frosina, Damien Breheny, James Murphy, Marianna Gaça, published by Institut für Tabakforschung GmbH
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License.