Table 1
Test products and puffing regime.
| Product | Product code/puffing regime | Product descriptor | Variant | Blend (top flavour) | Product change from “Base” | Change classification |
|---|---|---|---|---|---|---|
| Reference cigarette | 1R6F / HCI1 | Combustible reference | N/A | US Blend | N/A | N/A |
| Commercial comparator | THS 2.2_R / HCI2 | THP_benchmark | THS2.2 | Tobacco (Regular) | N/A | N/A |
| Base | THP1.0_BT / HCIm3 | THP_base | THP1.0 | Tobacco (Blended) | N/A | N/A |
| Variant 1 | THP1.1_RT / HCIm3 | THP_1 | THP1.1 | Tobacco (Rich) | Change in tobacco flavour and increased nicotine | Minor |
| Variant 2 | THP1.1_C / HCIm3 | THP_2 | THP1.1 | Citrus | Change in device aesthetics and top flavour | Minor |
| Variant 3 | THP1.1_S / HCIm3 | THP_3 | THP1.1 | Smooth | Change in device aesthetics and top flavour | Minor |
| Variant 4 | THP1.1_F / HCIm3 | THP_4 | THP1.1 | Fresh | Change in device aesthetics and top flavour | Minor |
| Variant 5 | THP1.1_RTF / HCIm3 | THP_5 | THP1.1 | Tobacco (Rich) | Change in device aesthetics, top flavour and foil wrap | Major4 |
1 Smoke generated by HCI conditions: 55 mL puff, 30 s interval, 2 s duration, bell profile, 100% vent blocking (22). Eight puffs per consumable. Data taken from (16).
2 Aerosol generated by HCI conditions: data taken from (7).
3 Aerosol generated by modified HCI conditions: 55 mL puff, 30 s interval, 2 s duration, bell profile, 0% vent blocking (THP consumables are designed to have open vents to allow hot gas to escape and avoid burning (15)). Eight puffs taken per consumable.
Abbreviations: HCI; Health Canada Intense; THS: Tobacco Heating System; THP: Tobacco Heating Product;
Table 2
Comparison of analyte emissions among products1.
| Analyte | Units | 1R6F2 | THP_benchmark3 | THP_base | THP variant | ||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||||
| Acetaldehyde | μg/consumable | 1859 (169) | 219 (31) | 122.6 (5.55) | 128.6 (7.89) | 131.8 (6.49) | 126.6 (12.62) | 123.6 (6.19) | 83.41 (3.95) |
| Acrolein | μg/consumable | 148 (22) | 11.3 (24) | 1.69 (0.13) | 1.70 (0.19) | 2.10 (0.21) | 1.99 (0.23) | 1.75 (0.15) | 1.24 (0.08) |
| Benzene | μg/consumable | 76 (5.8) | 0.649 (0.074) | 0.06 (0.02) | 0.09 (0.03) | 0.06 (0.02) | 0.04 (0.01) | 0.07 (0.03) | 0.06 (0.02) |
| Benzo[a]pyrene | ng/consumable | 11.4 (1.7) | NQ | 0.45 (0.15) | 0.31 (0.06) | 0.53 (0.06) | 0.43 (0.05) | 0.40 (0.05) | NQ |
| 1,3-Butadiene | μg/consumable | 114 (4) | 0.294 (0.042) | BDL | BDL | BDL | BDL | BDL | BDL |
| Formaldehyde | μg/consumable | 68.4 (3.9) | 5.53 (0.69) | 2.73 (0.96) | 2.38 (0.48) | 2.81 (1.56) | 2.65 (1.11) | 2.77 (1.22) | 1.51 (0.28) |
| NNK | ng/consumable | 208 (7) | 6.7 (0.6) | 7.46 (0.54) | 5.08 (0.63) | 10.01 (0.76) | 5.63 (1.18) | 6.46 (1.16) | 6.27 (0.84) |
| NNN | ng/consumable | 191 (8) | 17.2 (1.25) | 24.4 (1.96) | 16.5 (1.5) | 26.92 (1.72) | 0.04 (0.01) | 22.30 (3.16) | 13.31 (1.45) |
| CO | mg/consumable | 29.4 (0.6) | 0.532 (0.068) | BDL | BDL | BDL | BDL | BDL | BDL |
| Glycerol | mg/consumable | 1.36 (0.05) | 4.63 (0.83) | 2.12 (0.24) | 1.94 (0.35) | 2.81 (0.49) | 2.25 (0.37) | 2.38 (0.26) | 3.95 (0.29) |
| TPM | mg/consumable | 45.5 (2.2) | 10.3 (0.9) | 26.16 (1.49) | 27.12 (0.42) | 27.66 (1.25) | 26.34 (1.29) | 25.74 (1.84) | 26.11 (1.07) |
| Nicotine | mg/consumable | 2.0 (0.08) | 1.32 (0.16) | 0.38 (0.03) | 0.38 (0.04) | 0.46 (0.03) | 0.38 (0.03) | 0.38 (0.02) | 0.79 (0.02) |
| TAY | mg/consumable | 80.53 | 17.02 | 28.79 | 29.57 | 31.07 | 29.10 | 28.63 | 30.94 |
| TAY | mg/puff | 10.07 | 2.13 | 3.60 | 3.70 | 3.88 | 3.64 | 3.58 | 3.87 |
| TAY4 | mg | 32.1 | 181.05 | 306 | 314.5 | 329.8 | 309.4 | 304.3 | 329 |
| % reduction relative to (1R6F) | % | N/A | 93.24 | 95.41 | 96.36 | 94.82 | 97.35 | 95.68 | 97.07 |
2 Data taken from (16).
3 Data taken from (7).
Cigarette smoke TAY based on 3 puffs (10.7 × 3 = 32.1 mg); THP TAY based on 85 puffs (mg/puff × 85)
Abbreviations: NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NNN: N-nitrosonornicotine; CO: carbon monoxide; TPM: total particulate matter; NQ: not quantifiable; BDL: below detection limit; N/A: not applicable
Figure 1
Emissions and toxicology bridging data. (a) Percentage reductions in emissions of selected TobReg9 analytes for THP variants relative to a reference cigarette. (b) Viability of human lung cells exposed to cigarette smoke and THP aerosol. (c) Viability of cells exposed to 85 puffs of aerosol from THP_base, variants, and the MRTP-approved commercial THP_benchmark. (d) Viability data for reference cigarette, THP_benchmark, THP_base and variants contextualised against total analyte yields.
Figure 2
A schematic representation of a proposed future bridging process to leverage data from multiple sources.