Have a personal or library account? Click to login
Cigarette-Smoke- and Age-Dependent Oxidative Stress Effects in Rats Cover

References

  1. 1. Doll, R., R. Peto, K. Wheatley, R. Gray, and I. Sutherland: Mortality in Relation to Smoking: 40 Years’ Observations on Male British Doctors; BMJ 309 (1994) 901-911.
  2. 2. Forbes, W.F. and J.F. Gentleman: A Possible Similar Pathway Between Smoking-Induced Life Shortening and Natural Aging; J. Gerontol. 28 (1973) 302-311.
  3. 3. Grune, T. and K.J.A. Davies: Oxidative Processes in Aging; in: Handbook of the Biology of Aging, 5th Edition, edited by E.J. Masoro and S.N. Austad, Academic Press, San Diego, CA, USA, 2001, p. 25-58.
  4. 4. Kregel, K.C. and H.J. Zhang: An Integrated View of Oxidative Stress in Aging: Basic Mechanisms, Functional Effects, and Pathological Considerations; Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2007) R18-R36.10.1152/ajpregu.00327.200616917020
  5. 5. Beckman, K.B. and B.N. Ames: The Free Radical Theory of Aging Matures; Physiol. Rev. 78 (1998) 547-581.
  6. 6. Harman, D.: Free Radical Theory of Aging: An Update: Increasing the Functional Life Span; Ann. N. Y. Acad. Sci. 1067 (2006) 10-21.
  7. 7. Juránek, I., D. Nikitovic, D. Kouretas, A.W. Hayes, and A.M. Tsatsakis: Biological Importance of Reactive Oxygen Species in Relation to Difficulties of Treating Pathologies Involving Oxidative Stress by Exogenous Antioxidants; Food Chem. Toxicol. 61 (2013) 240-247.
  8. 8. Juránek, I. and Š. Bezek: Controversy of Free Radical Hypothesis: Reactive Oxygen Species - Cause or Consequence of Tissue Injury?; Gen. Physiol. Biophys. 24 (2005) 263-278.
  9. 9. Brand, M.D.: The Sites and Topology of Mitochondrial Superoxide Production; Exp. Gerontol. 45 (2010) 466-472.
  10. 10. Richter, C.: Oxidative Damage to Mitochondrial DNA and Its Relationship to Ageing; Int. J. Biochem. Cell. Biol. 27 (1995) 647-653.
  11. 11. Sohal, R.S. and M.J. Forster: Coenzyme Q, Oxidative Stress and Aging; Mitochondrion 7 Suppl. (2007) S103-S111.10.1016/j.mito.2007.03.006197849117482528
  12. 12. Höhn, A., T. Jung, S. Grimm, and T. Grune: Lipofuscin- Bound Iron as a Major Intracellular Source of Oxidants: Role in Senescent Cells; Free Radic. Biol. Med. 48 (2010) 1100-1108.
  13. 13. Fontana, L. and S. Klein, Aging: Adiposity, and Calorie Restriction; JAMA 297 (2007) 986-994.
  14. 14. Masoro, E.J.: Influence of Caloric Intake on Aging and on the Response to Stressors; J. Toxicol. Environ. Health B Crit. Rev. 1 (1998) 243-257.
  15. 15. Church, D.F. and W.A. Pryor: Free-Radical Chemistry of Cigarette Smoke and Its Toxicological Implications; Environ. Health Perspect. 64 (1985) 111-126.
  16. 16.Wooten, J.B., S. Chouchane, and T.E. McGrath: Tobacco Smoke Constituents Affecting Oxidative Stress; in: Cigarette and Oxidative Stress, edited by B.B. Halliwell and H.E. Poulsen, Springer, Berlin, Heidelberg, New York, 2006, p. 5-46.10.1007/3-540-32232-9_2
  17. 17. International Agency for Research on Cancer (IARC): Tobacco Smoke and Involuntary Smoking; IARC Monographs on the Evaluation of the Carcinogenic Risks of Chemicals to Humans Vol. 83, IARC, Lyon, France, 2004.
  18. 18. International Agency for Research on Cancer (IARC): Biological Data Relevant to the Carcinogenic Risk in Humans; in Tobacco Smoking, IARC Monographs On The Evaluation Of The Carcinogenic Risk Of Chemicals To Humans Vol. 38, IARC, Lyon, France 1986, p. 127-198.
  19. 19. Roemer, E., T.H. Ottmueller, H.J. Urban, C. Baillet- Mignard: SKH-1 Mouse Skin Painting: A Short-Term Assay to Evaluate the Tumorigenic Activity of Cigarette Smoke Condensate; Toxicol. Lett. 192 (2010) 155-161.
  20. 20. Roemer, E., T.H. Ottmueller, V. Zenzen, S. Wittke, F. Radtke, I. Bianco, and R.A. Carchman: Cytotoxicity, Mutagenicity, and Tumorigenicity of Mainstream Smoke from Three Reference Cigarettes Machine- Smoked to the Same Yields of Total Particulate Matter per Cigarette; Food Chem. Toxicol. 47 (2009) 1810-1818.
  21. 21. Schramke, H., T.J. Meisgen, F.J. Tewes, W. Gomm, and E. Roemer: The Mouse Lymphoma Thymidine Kinase Assay for the Assessment and Comparison of the Mutagenic Activity of Cigarette Mainstream Smoke Particulate Phase; Toxicology 227 (2006) 193-210.
  22. 22. Robinson, A.B., J.A. Stogsdill, J.B. Lewis, T.T. Wood, and P.R. Reynolds: RAGE and Tobacco Smoke: Insights into Modeling Chronic Obstructive Pulmonary Disease; Front. Physiol. 3 (2012) 301.
  23. 23. Nicholl, I.D., A.W. Stitt, J.E. Moore, A.J. Ritchie, D.B. Archer, and R. Bucala: Increased Levels of Advanced Glycation Endproducts in the Lenses and Blood Vessels of Cigarette Smokers; Mol. Med. 4 (1998) 594-601.
  24. 24. Kasper, M. and R.H.W. Funk: Age-Related Changes in Cells and Tissues Due to Advanced Glycation End Products (AGEs); Arch. Gerontol. Geriatr. 32 (2001) 233-243.
  25. 25. Bayne, K.: Developing Guidelines on the Care and Use of Animals; Ann N Y Acad Sci 862 (1998) 105-110.10.1111/j.1749-6632.1998.tb09122.x9928211
  26. 26. Diana, J.N. and A. Vaught: Research Cigarettes; University of Kentucky Printing Services, Lexington KY, USA, 1990.
  27. 27. International Organization for Standardization (ISO): ISO 3308. Routine Analytical Cigarette Smoking Machine - Definitions and Standard Conditions, 4th Edition, ISO, Geneva, Switzerland, 2000.
  28. 28. Terpstra, P.M., A. Teredesai, P.M. Vanscheeuwijck, J. Verbeeck, G. Schepers, F. Radtke, P. Kuhl, W. Gomm, E. Anskeit, and G. Patskan: Toxicological Evaluation of an Electrically Heated Cigarette. Part 4: Subchronic Inhalation Toxicology; J. Appl. Toxicol. 23 (2003) 349-362.
  29. 29. Nyengaard, J.R.: Stereologic Methods and Their Application in Kidney Research; J. Am. Soc. Nephrol. 10 (1999) 1100-1123.
  30. 30. Bader, N., A. Bosy-Westphal, A. Koch, G. Rimbach, A. Weimann, H.E. Poulsen, and M.J. Müller: Effect of Hyperbaric Oxygen and Vitamin C and E Supplementation on Biomarkers of Oxidative Stress in Healthy Men; Br. J. Nutr. 98 (2007) 826-833.
  31. 31. Vasquez, M.Z.: Recommendations for Safety Testing with the in Vivo Comet Assay; Mutat. Res. 747 (2012) 142-156.
  32. 32. Gil, L., W. Siems, B. Mazurek, J. Gross, P. Schroeder, P. Voss, and T. Grune: Age-Associated Analysis of Oxidative Stress Parameters in Human Plasma and Erythrocytes; Free Radic. Res. 40 (2006) 495-505.
  33. 33. Buss, H., T.P. Chan, K.B. Sluis, N.M. Domigan, and C.C. Winterbourn: Protein Carbonyl Measurement by a Sensitive ELISA Method; Free Radic. Biol. Med. 23 (1997) 361-366.
  34. 34. Voss, P., L. Horakova, M. Jakstadt, D. Kiekebusch, and T. Grune: Ferritin Oxidation and Proteasomal Degradation: Protection by Antioxidants; Free Radic. Res. 40 (2006) 673-683.
  35. 35. Kasper, M., D. Seidel, L. Knels, N. Morishima, A. Neisser, S. Bramke, and R. Koslowski: Early Signs of Lung Fibrosis After in Vitro Treatment of Rat Lung Slices with CdCl2 and TGF-β1; Histochem. Cell. Biol. 121 (2004) 131-140.
  36. 36. Kalousová, M., T. Zima, V. Tesař, S. Dusilová-Sulková, and J. Skrha: Advanced Glycoxidation End Products in Chronic Diseases - Clinical Chemistry and Genetic Background; Mutat. Res. 579 (2005) 37-46.
  37. 37. Romano, A.D., G. Serviddio, A. de Matthaeis, F. Bellanti, and G. Vendemiale: Oxidative Stress and Aging; J. Nephrol. 23 Suppl. 15 (2010) S29-S36.
  38. 38. Breusing, N., J. Arndt, P. Voss, N. Bresgen, I. Wiswedel, A. Gardemann, W. Siems, and T. Grune: Inverse Correlation of Protein Oxidation and Proteasome Activity in Liver and Lung; Mech. Ageing Dev. 130 (2009) 748-753.
  39. 39. Ribarič, S.: Diet and Aging; Oxid. Med. Cell. Longev. (2012) 741468.10.1155/2012/741468342596122928085
  40. 40. Kim, L.G., J. Adamson, and S. Ebrahim: Influence of Life-Style Choices on Locomotor Disability, Arthritis and Cardiovascular Disease in Older Women: Prospective Cohort Study; Age Ageing 42 (2013) 696-701.
  41. 41. Burke, G.L., A.M. Arnold, D.E. Bild, M. Cushman, L.P. Fried, A. Newman, C. Nunn, J. Robbins, and for the CHS Collaborative Research Group: Factors Associated with Healthy Aging: The Cardiovascular Health Study; J. Am. Geriatr. Soc. 49 (2001) 254-262.
  42. 42. Csordas, A., G. Wick, G. Laufer, and D. Bernhard: An Evaluation of the Clinical Evidence on the Role of Inflammation and Oxidative Stress in Smoking-Mediated Cardiovascular Disease; Biomark. Insights 3 (2008) 127-139.
  43. 43. Goodson, N.J., D.P.M. Symmons, D.G.I. Scott, D. Bunn, M. Lunt, and A.J. Silman: Baseline Levels of CReactive Protein and Prediction of Death from Cardiovascular Disease in Patients with Inflammatory Polyarthritis: A Ten-Year Followup Study of a Primary Care- Based Inception Cohort; Arthritis. Rheum. 52 (2005) 2293-2299.
  44. 44. Kapetanovic, M.C., E. Lindqvist, P. Geborek, T. Saxne, and K. Eberhard: Long-Term Mortality Rate in Rheumatoid Arthritis Patients with Disease Onset in the 1980s; Scand. J. Rheumatol. 40 (2011) 433-438.
  45. 45. Turesson, C., R.L. McClelland, T.J.Christianson, and E.L. Matteson: Severe Extra-Articular Disease Manifestations Are Associated with an Increased Risk of First Ever Cardiovascular Events in Patients with Rheumatoid Arthritis; Ann. Rheum. Dis. 66 (2007) 70-75.
  46. 46. Bernhard, D., C. Moser, A. Backovic, and G. Wick: Cigarette Smoke - An Aging Accelerator?; Exp. Gerontol. 42 (2007) 160-165.
  47. 47. Ristow, M. and S. Schmeisser: Extending Life Span by Increasing Oxidative Stress; Free Radic. Biol. Med. 51 (2011) 327-336.
  48. 48. Salmon, A.B., A. Richardson, and V.I. Pérez: Update on the Oxidative Stress Theory of Aging: Does Oxidative Stress Play a Role in Aging or Healthy Aging?; Free Radic. Biol. Med. 48 (2010) 642-655.
  49. 49. Gems, D. and L. Partridge: Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts; Annu. Rev. Physiol. 75 (2013) 621-644.
  50. 50. Kim, D.-H., Y.-S. Suh, and K.-C. Mun: Tissue Levels of Malondialdehyde after Passive Smoke Exposure of Rats for a 24-Week Period; Nicotine Tob. Res. 6 (2004) 1039-1042.
  51. 51. Kocyigit, A., S. Selek, H. Celik, and M. Dikilitas: Mononuclear Leukocyte DNA Damage and Oxidative Stress: The Association with Smoking of Hand-Rolled and Filter-Cigarettes; Mutat. Res. 721 (2011) 136-141.
  52. 52. Murărescu, E.D., R. Iancu, and M.S. Mihailovici: Morphological Changes Positive Correlates with Oxidative Stress in COPD. Preliminary Data of an Experimental Rat Model - Study and Literature Review; Rom. J. Morphol. Embryol. 48 (2007) 59-65.
  53. 53. Nielsen, F., B.B. Mikkelsen, J.B. Nielsen, H.R. Andersen, and P. Grandjean: Plasma Malondialdehyde as Biomarker for Oxidative Stress: Reference Interval and Effects of Life-Style Factors; Clin. Chem. 43 (1997) 1209-1214.
  54. 54. Pekmez, H., I. Kus, N. Colakoglu, M. Ogeturk, H. Ozyurt, A.O. Turkoglu, and M. Sarsilmaz: The Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) Against Liver Damage Induced by Cigarette Smoke Inhalation in Rats; Cell. Biochem. Funct. 25 (2007) 395-400.
  55. 55. Ungvari, Z., A. Csiszar, D. Sosnowska, E.E. Philipp, C.M. Campbell, P.R. McQuary, T.T. Chow, M. Coelho, E.S. Didier, S. Gelino, M.A. Holmbeck, I. Kim, E. Levy, W.E. Sonntag, P.W. Whitby, S.N. Austad, and I. Ridgway: Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa); J. Gerontol. A Biol. Sci. Med. Sci. 68 (2013) 359-367.
  56. 56. Kaneko, T., S. Tahara, and M. Matsuo: Retarding Effect of Dietary Restriction on the Accumulation of 8- Hydroxy-2'-deoxyguanosine in Organs of Fischer 344 Rats during Aging; Free Radic. Biol. Med. 23 (1997) 76-81.
  57. 57. Sohal, R.S., S. Agarwal, M. Candas, M.J. Forster, and H. Lal: Effect of Age and Caloric Restriction on DNA Oxidative Damage in Different Tissues of C57BL/6 Mice; Mech. Ageing Dev. 76 (1994) 215-224.
  58. 58. Vyskočilová, E., B. Szotáková, L. Skálová, H. Bártíková, J. Hlavácová, and I. Boušová: Age-Related Changes in Hepatic Activity and Expression of Detoxification Enzymes in Male Rats; Biomed. Res. Int. (2013) 408573.10.1155/2013/408573373649823971034
  59. 59. Davies, S.M.K., A. Poljak, M.W. Duncan, G.A. Smythe, and M.P. Murphy: Measurements of Protein Carbonyls, ortho- and meta-Tyrosine and Oxidative Phosphorylation Complex Activity in Mitochondria from Young and Old Rats; Free Radic. Biol. Med. 31 (2001) 181-190.
  60. 60. Goto, S., R. Takahashi, Z. Radak, and R. Sharma: Beneficial Biochemical Outcomes of Late-Onset Dietary Restriction in Rodents; Ann. N. Y. Acad. Sci. 1100 (2007) 431-441.
  61. 61. Youngman, L.D., J.Y. Park, and B.N. Ames: Protein Oxidation Associated with Aging is Reduced by Dietary Restriction of Protein or Calories; Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 9112-9116.
  62. 62. Sato, T., K. Seyama, Y. Sato, H. Mori, S. Souma, T. Akiyoshi, Y. Kodama, T. Mori, S. Goto, K. Takahashi, Y. Fukuchi, N. Maruyama, and A. Ishigami: Senescence Marker Protein-30 Protects Mice Lungs from Oxidative Stress, Aging, and Smoking; Am. J. Respir. Crit. Care Med. 174 (2006) 530-537.
  63. 63. Jana, C.K., N. Das, and R.S. Sohal: Specificity of Age- Related Carbonylation of Plasma Proteins in the Mouse and Rat; Arch. Biochem. Biophys. 397 (2002) 433-439.
  64. 64. Organisation for Economic Co-operation and Development (OECD): Test No. 413: Subchronic Inhalation Study: 90-Day Study; OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris, 2009.
  65. 65. Vanscheeuwijck, P.M., A. Teredesai, P.M. Terpstra, J. Verbeeck, P. Kuhl, B. Gerstenberg, S. Gebel, and E.L. Carmines: Evaluation of the Potential Effects of Ingredients Added to Cigarettes. Part 4: Subchronic Inhalation Toxicity; Food Chem. Toxicol. 40 (2002) 113-131.
  66. 66. Müller, T. and S. Gebel: The Cellular Stress Response Induced by Aqueous Extracts of Cigarette Smoke is Critically Dependent on the Intracellular Glutathione Concentration; Carcinogenesis 19 (1998) 797-801.
  67. 67. Hoffmann, H., C. Isner, J. Högel, and G. Speit: Genetic Polymorphisms and the Effect of Cigarette Smoking in the Comet Assay; Mutagenesis 20 (2005) 359-364.
  68. 68. Fraga, C.G., M.K. Shigenaga, J.W. Park, P. Degan, and B.N. Ames: Oxidative Damage to DNA During Aging: 8-Hydroxy-2'-deoxyguanosine in Rat Organ DNA and Urine; Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 4533-4537.
  69. 69. Tsuda, S., N. Matsusaka, S. Ueno, N. Susa, and Y.F. Sasaki: The Influence of Antioxidants on Cigarette Smoke-Induced DNA Single-Strand Breaks in Mouse Organs: A Preliminary Study with the Alkaline Single Cell Gel Electrophoresis Assay; Toxicol. Sci. 54 (2000) 104-109.
  70. 70.Weber, S., M. Hebestreit, T. Wilms, L.L. Conroy, and G. Rodrigo: Comet Assay and Air-Liquid Interface Exposure System: A New Combination to Evaluate Genotoxic Effects of Cigarette Whole Smoke in Human Lung Cell Lines; Toxicol. In Vitro 27 (2013) 1987-1991.
  71. 71. Lima, P.H.O., Y.K. Sinzato, M. da Silva S. de Souza, M.G. Braz, M.V.C. Rudge, and D.C. Damasceno: Evaluation of Level of DNA Damage in Blood Leukocytes of Non-Diabetic and Diabetic Rat Exposed to Cigarette Smoke; Mutat. Res. 628 (2007) 117-122.
  72. 72. Vasquez, M.Z.: Combining the in Vivo Comet and Micronucleus Assays: A Practical Approach to Genotoxicity Testing and Data Interpretation; Mutagenesis 25 (2010) 187-199.
  73. 73. Villard, P.-H., E.M. Seree, J.-L. Re, M. De Meo, Y. Barra, L. Attolini, G. Dumenil, J. Ctalin, A. Durand, and B. Lacarelle: Effects of Tobacco Smoke on the Gene Expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a Subfamilies in Mouse Liver and Lung: Relation to Single Strand Breaks of DNA; Toxicol. Appl. Pharmacol. 148 (1998) 195-204.
  74. 74. Alarie, Y.: Computer-Based Bioassay for Evaluation of Sensory Irritation of Airborne Chemicals and Its Limit of Detection; Arch. Toxicol. 72 (1998) 277-282.
  75. 75. Grafström, R.C., J.M. Dypbukt, K. Sundqvist, L. Atzori, I. Nielsen, R.D. Curren, and C.C. Harris: Pathobiological Effects of Acetaldehyde in Cultured Human Epithelial Cells and Fibroblasts; Carcinogenesis 15 (1994) 985-990.
  76. 76. Ben-Zaken Cohen, S., P.D. Paré, S.F. Man, and D.D. Sin: The Growing Burden of Chronic Obstructive Pulmonary Disease and Lung Cancer in Women: Examining Sex Differences in Cigarette Smoke Metabolism; Am. J. Respir. Crit. Care Med. 176 (2007) 113-120.
  77. 77.Koyama, H. and D.M. Geddes: Genes, Oxidative Stress, and the Risk of Chronic Obstructive Pulmonary Disease; Thorax 53 Suppl. 2 (1998) S10-S14.10.1136/thx.53.2008.S10
  78. 78. Nishikawa, A., Y. Mori, I.-S. Lee, T. Tanaka, and M. Hirose: Cigarette Smoking, Metabolic Activation and Carcinogenesis; Curr Drug Metab 5 (2004) 363-373.
  79. 79. Collins, A.R.: Measuring Oxidative Damage to DNA and Its Repair with the Comet Assay; Biochim. Biophys. Acta 1840 (2014) 794-800.
  80. 80. Collins, A.R., V.L. Dobson, M. Dusinská, G. Kennedy, and R. Stétina: The Comet Assay: What Can It Really Tell Us?; Mutat. Res. 375 (1997) 183-193.
  81. 81. Briedé, J.J., R.W.L. Godschalk, M.T.G. Emans, T.M.C.M. de Kok, E. van Agen, J.M.S. van Maanen, F.-J. van Schooten, and J.C.S. Kleinjans: In Vitro and in Vivo Studies on Oxygen Free Radical and DNA Adduct Formation in Rat Lung and Liver During Benzo[a]pyrene Metabolism; Free Radic. Res. 38 (2004) 995-1002.
  82. 82. Lee, H.C., M.L. Lim, C.Y. Lu, V.W. Liu, H.J. Fahn, C. Zhang, P. Nagley, and Y.H. Wei: Concurrent Increase of Oxidative DNA Damage and Lipid Peroxidation Together with Mitochondrial DNA Mutation in Human Lung Tissues During Aging - Smoking Enhances Oxidative Stress on the Aged Tissues; Arch. Biochem. Biophys. 362 (1999) 309-316.
  83. 83. Torres, C.A. and V.I. Perez: Proteasome Modulates Mitochondrial Function During Cellular Senescence; Free Radic. Biol. Med. 44 (2008) 403-414.
  84. 84. Baraibar, M.A., R. Ladouce, and B. Friguet: Proteomic Quantification and Identification of Carbonylated Proteins upon Oxidative Stress and during Cellular Aging; J. Proteomics 92 (2013) 63-70.
  85. 85. Kolovou, G.D., V. Kolovou, and S. Mavrogeni: We Are Ageing; Biomed. Res. Int. (2014) 808307.10.1155/2014/808307409057425045704
  86. 86. Vučević, D., Mladenović, M. Ninković, V. Alksić, M.N. Stanković, M. Stanković, B. Jorgačević, R.J. Vukičević, and T. Radosavljević: The Effects of Caloric Restriction Against Ethanol-Induced Oxidative and Nitrosative Cardiotoxicity and Plasma Lipids in Rats; Exp. Biol. Med. (Maywood) 238 (2013) 1396-1405.
  87. 87. Hoeng, J., R. Deehand, D. Pratt, F. Martin, A. Sewer, T.M. Thomson, D.A. Drubin, C.A. Waters, D. de Graaf, and M.C. Peitsch: A Network-Based Approach to Quantifying the Impact of Biologically Active Substances; Drug. Discov. Today. 17 (2012) 413-418.
  88. 88. Hartung, T.: A Toxicology for the 21st Century - Mapping the Road Ahead; Toxicol. Sci. 109 (2009) 18-23.
  89. 89. Mahadevan, B., R.D. Snyder, M.D. Waters, R.D. Benz, R.A. Kemper, R.R. Tice, and A.M. Richard: Genetic Toxicology in the 21st Century: Reflections and Future Directions; Environ. Mol. Mutagen. 52 (2011) 339-354.
  90. 90. Stephens, M.L., C. Barrow, M.E. Andersen, K. Boekelheide, P.L. Carmichael, M.P. Holsapple, and M. Lafranconi: Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop; Toxicol. Sci. 125 (2012) 327-334.
  91. 91. Rowlands, J.C., M. Sander, and J. Bus: Future Tox: Building the Road for 21st Century Toxicology and Risk Assessment Practices; Toxicol. Sci. 137 (2013) 269-277.
Language: English
Page range: 109 - 120
Submitted on: Mar 7, 2014
Accepted on: Aug 22, 2014
Published on: Nov 5, 2014
Published by: Institut für Tabakforschung GmbH
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2014 Thomas Meisgen, Ewald Roemer, Lynda L. Conroy, Jeroen Hostens, Marie Vasquez, Andreas Humeny, Michaela Moehring, Walter K. Schlage, Michael Kasper, published by Institut für Tabakforschung GmbH
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.