Abstract
Chemical and analytical characteristics of dithiocarbamates are described in detail. Thorn and Ludwig (49) published an excellent book dealing in detail with a large number of problems discussed in this publication. Present pharmacological examinations give no indication as to the toxicological hazards of dithiocarbamates. With regard to the application of dithiocarbamates in general, food regulations (not referring to tobacco) issued by governmental authorities of the United States and New Zealand limit the maximal allowable concentrations of DTC-residues to 5 to 10 ppm. Measures against Peronospora tabacina Adam are controlled by governmental authorities or state monopolies. Successful preventive treatment of tobacco requires a dosage of approximately 1000 ppm. At the same time this quantity represents the tolerable limit up to which the tobacco taste is not detrimentally affected. Secondary impregnations with Zineb and Maneb above the 1000 ppm limit affected the taste somewhat. Dithiocarbamates as such do not pass into smoke