Have a personal or library account? Click to login

New therapeutic strategies based on molecularly targeted therapy in glioblastoma – a case report and review of the literature

Current Issues in Pharmacy and Medical Sciences
Volume 35 (2022): Issue 4 (December 2022)
By:
Open Access
|Feb 2023

References

  1. 1. Grimm SA, Chamberlain MC. Anaplastic astrocytoma. CNS Oncol. 2016;5(3):145-57.10.2217/cns-2016-0002604263227230974
    Search in Google ScholarBack to article
  2. 2. Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, et al. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020;22(8):1073-113.10.1093/neuonc/noaa106759455732328653
    Search in Google ScholarBack to article
  3. 3. Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, et al. NOA-04 randomized Phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol. 2009;27(35):5874-80.10.1200/JCO.2009.23.649719901110
    Search in Google ScholarBack to article
  4. 4. Saha D, Wakimoto H, Peters CW, Antoszczyk SJ, Rabkin SD, Martuza RL. Combinatorial effects of VEGFR kinase inhibitor axitinib and oncolytic virotherapy in mouse and human glioblastoma stem-like cell models. Clin Cancer Res. 2018;24(14):3409-22.10.1158/1078-0432.CCR-17-1717605008529599413
    Search in Google ScholarBack to article
  5. 5. Davis ME. Glioblastoma: Overview of disease and treatment. Clin J Oncol Nurs. 2016;20(5 Suppl):S2-8.10.1188/16.CJON.S1.2-8512381127668386
    Search in Google ScholarBack to article
  6. 6. Perry JR Laperriere N, O’Callaghan CJ, et al. Trial investigators short-course radiation plus temozolomide in elderly patients with glioblastoma. N Engl J Med. 2017;376(11):1027-37.10.1056/NEJMoa161197728296618
    Search in Google ScholarBack to article
  7. 7. Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, et al. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev. 2014;23(10):1985-96.10.1158/1055-9965.EPI-14-0275418500525053711
    Search in Google ScholarBack to article
  8. 8. Wang GW, Li BM. (2020). Efficacy of surgery for the treatment of astrocytoma: A protocol of systematic review and meta-analysis. Medicine. 2020;99(23).10.1097/MD.0000000000020485
    Search in Google ScholarBack to article
  9. 9. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH, et al. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med. 1980;303:1323-9.10.1056/NEJM1980120430323037001230
    Search in Google ScholarBack to article
  10. 10. Chang CH, Horton J, Schoenfeld D, Salazer O, Perez Tamayo R, Kramer S, et al. Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer. 1983;52:997-1007.10.1002/1097-0142(19830915)52:6<997::AID-CNCR2820520612>3.0.CO;2-2
    Search in Google ScholarBack to article
  11. 11. EORTC Brain Tumor Group. Effect of CCNU on survival rate of objective remission and duration of free interval in patients with malignant brain glioma –final evaluation. E.O.R.T.C. Brain Tumor Group. Eur J Cancer. 1978;14:851-6.10.1016/0014-2964(78)90100-7
    Search in Google ScholarBack to article
  12. 12. EORTC Brain Tumor Group. Evaluation of CCNU, VM26 plus CCNU, and procarbazine in supratentorial brain gliomas. Final evaluation of a randomized study. European Organization for Research on Treatment of Cancer (EORTC) Brain Tumor Group. J Neurosurg. 1981;55:27-31.10.3171/jns.1981.55.1.00277017081
    Search in Google ScholarBack to article
  13. 13. Edwards MS, Levin VA, Wilson CB. Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials. Cancer Treat Rep. 1980;64:1179-205.
    Search in Google ScholarBack to article
  14. 14. Arbab AS, Rashid MH, Angara K, Borin TF, Lin PC, Jain M, et al. Major challenges and potential microenvironment-targeted therapies in glioblastoma. Int J Mol Sci. 2017;18(12):2732.10.3390/ijms18122732575133329258180
    Search in Google ScholarBack to article
  15. 15. Wang N, Jain RK, Batchelor TT. New directions in anti-angiogenic therapy for glioblastoma. Neurotherapeutics. 2017;14(2):321-32.10.1007/s13311-016-0510-y539898528083806
    Search in Google ScholarBack to article
  16. 16. Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):709-22.10.1056/NEJMoa130834524552318
    Search in Google ScholarBack to article
  17. 17. Wick W, Cloughesy TF, Nishikawa R, Mason W, Saran F, Henrikson R, et al. Tumor response based on adapted Macdonald criteria and assessment of pseudoprogression (PsPD) in the phase III AVAglio trial of bevacizumab (Bv) plus temozolomide (T) plus radiotherapy (RT) in newly diagnosed glioblastoma (GBM). J Clin Oncol. 2013;31(15).10.1200/jco.2013.31.15_suppl.2002
    Search in Google ScholarBack to article
  18. 18. Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):699-708.10.1056/NEJMoa1308573420104324552317
    Search in Google ScholarBack to article
  19. 19. Bayer Healthcare Pharmaceuticals Inc. Regorafenib (Stivarga). U.S Food and Drug Administration Prescribing Information; 2019.
    Search in Google ScholarBack to article
  20. 20. Bayer AG. Regorafenib (Stivarga). Summary of product characteristics. European Medicines Agency; 2018.
    Search in Google ScholarBack to article
  21. 21. Thomas AA, Omuro A. Current role of anti-angiogenic strategies for glioblastoma. Curr Treat Options Oncol. 2014;15:551-66.10.1007/s11864-014-0308-225173555
    Search in Google ScholarBack to article
  22. 22. Huang WJ, Chen WW, Zhang X. Glioblastoma multiforme: effect of hypoxia and hypoxia inducible factors on therapeutic approaches. Oncol Lett. 2016;12 (2016):2283-8.10.3892/ol.2016.4952503835327698790
    Search in Google ScholarBack to article
  23. 23. Lombardi G, De Salvo GL, Brandes AA, Eoli M, Ruda R, Faedi M, et al. Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial. Lancet Oncol. 2019;20:110-9.10.1016/S1470-2045(18)30675-230522967
    Search in Google ScholarBack to article
  24. 24. Alexander BM, Ba S, Berger MS, Berry DA, Cavenee WK, Chang SM, et al. GBM AGILE Network. Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE. Clin Cancer Res. 2018;24(4):737-43.10.1158/1078-0432.CCR-17-076428814435
    Search in Google ScholarBack to article
  25. 25. Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, et al. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med. 2015;372(26):2481-98.10.1056/NEJMoa1402121453001126061751
    Search in Google ScholarBack to article
  26. 26. Vizcaíno MA, Shah S, Eberhart CG, Rodriguez FJ. Clinicopathologic implications of NF1 gene alterations in diffuse gliomas. Hum Pathol. 2015;46(9):1323-30.10.1016/j.humpath.2015.05.014470309526190195
    Search in Google ScholarBack to article
  27. 27. Gao M, Yang J, Gong H, Lin Y, Liu J. Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis. Front Pharmacol. 2021;12:760055.10.3389/fphar.2021.760055856643634744739
    Search in Google ScholarBack to article
  28. 28. Wen PY, Stein A, van den Bent M, De Greve J, Wick A, de Vos FYFL, von Bubnoff N. Dabrafenib plus trametinib in patients with BRAFV600E-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial. Lancet Oncol. 2022;23(1):53-64.10.1016/S1470-2045(21)00578-734838156
    Search in Google ScholarBack to article
  29. 29. Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, et al. Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial. Lancet Oncol. 2019;20(7):1011-22.10.1016/S1470-2045(19)30277-3662820231151904
    Search in Google ScholarBack to article
  30. 30. Schreck KC, Allen AN, Wang J, Pratilas CA. Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma. Neurooncol Adv. 2020;2(1):138.10.1093/noajnl/vdaa138766844633235998
    Search in Google ScholarBack to article
  31. 31. Maxwell MJ, Arnold A, Sweeney H, Chen L, Lih TM, Schnaubelt M et al. Unbiased proteomic and phosphoproteomic analysis identifies response signatures and novel susceptibilities after combined MEK and mTOR inhibition in BRAFV600E mutant glioma. Mol Cell Proteomics. 2021;20:10023.10.1016/j.mcpro.2021.100123836384034298159
    Search in Google ScholarBack to article
  32. 32. Arnold A, Yuan M, Price A, Harris L, Eberhart CG, Raabe EH. Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity. Neuro Oncol. 2020;22(4):563-74.10.1093/neuonc/noz230715865531841591
    Search in Google ScholarBack to article
  33. 33. Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, et al. Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial. Lancet Oncol. 2019;20(7):1011-22.10.1016/S1470-2045(19)30277-3
    Search in Google ScholarBack to article
  34. 34. Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, et al. Selumetinib for children with plexiform neurofibromas. Lancet Oncol. 2020;18(2):e69-42.10.1016/S1470-2045(17)30009-828089105
    Search in Google ScholarBack to article
  35. 35. Burger MC, Ronellenfitsch MW, Lorenz NI, Wagner M, Voss M, Capper D, et al. Dabrafenib in patients with recurrent, BRAF V600E mutated malignant glioma and leptomeningeal disease. Oncol Rep. 2017;38(6):3291-6.10.1093/neuonc/nox168.877
    Search in Google ScholarBack to article
  36. 36. Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med. 2012;367(18):1694-703.10.1056/NEJMoa1210093354929523020132
    Search in Google ScholarBack to article
  37. 37. Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, et al. Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Oncotarget. 2016;7(46):75839-53.10.18632/oncotarget.12419534278227713119
    Search in Google ScholarBack to article
  38. 38. Di Stefano AL, Fucci A, Frattini V, Labussiere M, Mokhtari K, Zoppoli P, et al. Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma. Clin Cancer Res. 2015;21(14):3307-17.10.1158/1078-0432.CCR-14-2199450621825609060
    Search in Google ScholarBack to article
  39. 39. Lassman AB, Sepúlveda-Sánchez JM, Cloughesy TF, Gil-Gil MJ, Puduvalli VK, Raizer JJ, et al. Infigratinib in patients with recurrent gliomas and FGFR alterations: A multicenter phase II study. Clin Cancer Res. 2022;28(11):2270-7.10.1158/1078-0432.CCR-21-2664916770235344029
    Search in Google ScholarBack to article
  40. 40. Lasorella A, Sanson M, Iavarone A. FGFR-TACC gene fusions in human glioma. Neuro Oncol. 2017;19(4):475-83.10.1093/neuonc/now240
    Search in Google ScholarBack to article
  41. 41. Torre M, Vasudevaraja V, Serrano J, DeLorenzo M, Malinowski S, Blandin AF, et al. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathol Commun. 2020;8(1):107.10.1186/s40478-020-00980-z736264632665022
    Search in Google ScholarBack to article
  42. 42. Solomon JP, Benayed R, Hechtman JF, Ladanyi M. Identifying patients with NTRK fusion cancer. Ann Oncol. 2019;30.10.1093/annonc/mdz384685981731738428
    Search in Google ScholarBack to article
  43. 43. Mayr L, Guntner AS, Madlener S, Schmook MT, Peyrl A, Azizi AA, et al. Cerebrospinal fluid penetration and combination therapy of entrectinib for disseminated ROS1/NTRK-fusion positive pediatric high-grade glioma. J Pers Med. 2020;10(4):290.10.3390/jpm10040290776648333353026
    Search in Google ScholarBack to article
  44. 44. Cocco E, Scaltriti M, Drilon A. NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol. 2018;15(12):731-47.10.1038/s41571-018-0113-0641950630333516
    Search in Google ScholarBack to article
  45. 45. Doebele RC, Drilon A, Paz-Ares L, Siena S, Shaw AT, Farago AF, et al. Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials. Lancet Oncol. 2020;21(2):271-82.10.1016/S1470-2045(19)30691-6746163031838007
    Search in Google ScholarBack to article
  46. 46. Doz F, van Tilburg CM, Geoerger B, Højgaard M, Øra I, Boni V, et al. Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors. Neuro Oncol. 2022;24(6):997-1007.10.1093/neuonc/noab274915944234850167
    Search in Google ScholarBack to article
  47. 47. Garcia-Foncillas J, Bokemeyer C, Italiano A, Keating K, Paracha N, Fellous M, et al. Indirect treatment comparison of larotrectinib versus entrectinib in treating patients with TRK gene fusion cancers. Cancers (Basel). 2022;14(7):1793.10.3390/cancers14071793899745735406565
    Search in Google ScholarBack to article
  48. 48. Bagchi A, Orr BA, Campagne O, Dhanda S, Nair S, Tran Q, et al. Lorlatinib in a child with ALK-fusion-positive high-grade glioma. N Engl J Med. 2021;385(8):761-3.10.1056/NEJMc2101264867268234407349
    Search in Google ScholarBack to article
  49. 49. Davare MA, Henderson JJ, Agarwal A, Wagner JP, Iyer SR, Shah N, et al. Rare but Recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma. Clin Cancer Res. 2018;24(24):6471-82.10.1158/1078-0432.CCR-18-1052629521430171048
    Search in Google ScholarBack to article
  50. 50. Shaw AT, Felip E, Bauer TM, Besse B, Navarro A, Postel-Vinay S, et al. Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial. Lancet Oncol. 2017;18(12):1590-9.10.1016/S1470-2045(17)30680-0577723329074098
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/cipms-2022-0036 | Journal eISSN: 2300-6676 | Journal ISSN: 2084-980X
Journal RSS Feed
Language: English
Page range: 206 - 211
Submitted on: Sep 7, 2022
Accepted on: Dec 1, 2022
Published on: Feb 9, 2023
Published by: Sciendo
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
glioblastoma multiforme (GBM),
treatment,
case report,
review of the literature
Related subjects:
Medicine,
Clinical medicine,
Clinical medicine, other,
Pharmacology, toxicology,
Pharmacy,
Pharmacy, other

© 2023 Katarzyna Szklener, Anna Rodzajewska, Weronika Kurylo, Slawomir Mandziuk, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Previous articleVolume 35 (2022): Issue 4 (December 2022)Next article