The role of appetite-controlling hormones in the development of eating disorders in diabetic 2 patients

Alina Urbanovych; Fedir Laniush

doi:10.2478/cipms-2022-0016

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The role of appetite-controlling hormones in the development of eating disorders in diabetic 2 patients

Current Issues in Pharmacy and Medical Sciences

Volume 35 (2022): Issue 2 (August 2022)

By: Alina Urbanovych and Fedir Laniush

Open Access

|Sep 2022

Abstract

Binge eating disorder (BED) and night eating syndrome (NES) are common eating disorders (EDs) in individuals with diabetes type 2 (DT2). They worsen metabolic control, have a negative impact on physical and mental health and reduce quality of life. The roles of appetite-controlling hormones – leptin and ghrelin – is not clear enough in EDs and need to be investigated in order to establish new approaches and markers of EDs. Aim: To assess the difference in leptin and ghrelin levels in DT2 patients with and without EDs. 57 patients with DT2 were involved in the study. After physical examination and screening for EDs, blood samples for leptin and ghrelin measuring were obtained.

Results: 19 participants (33.3%) were screened positively for ED (BE or NES). Leptin levels were higher in participants with ED (p<0.05). Conversely, ghrelin levels were lower in those with BE or NES (p<0.05).

Leptin level is increased in DT2 individuals with BED and NES, whereas ghrelin is decreased. Leptin and ghrelin alterations maintain emotional eating, increase the frequency of binge and night eating episodes. In screening for EDs, assessing leptin and ghrelin levels will facilitate obesity reduction and improve metabolic control in diabetic patients.

References

1. Arroyo-Johnson C, Mincey KD. Obesity epidemiology worldwide. Gastroenterol Clin North Am. 2016;45(4):571-9.10.1016/j.gtc.2016.07.012559916327837773
Open DOI Search in Google Scholar Open in PubMed Back to article
2. Harris SR, Carrillo M, Fujioka K. Binge-eating disorder and Type 2 diabetes: A review. Endocr Pract. 2021;27(2):158-64.10.1016/j.eprac.2020.10.00533554873
Open DOI Search in Google Scholar Open in PubMed Back to article
3. Allison KC, Crow SJ, Reeves RR, Smith West D, Foreyt JP, DiLillo VG, et al. Binge eating disorder and night eating syndrome in adults with type 2 diabetes. Obesity (Silver Spring). 2007;15(5):1287-93.10.1038/oby.2007.150275327817495205
Open DOI Search in Google Scholar Open in PubMed Back to article
4. Urbanovych AM, Laniush FV. The role of ghrelin and serotonin in the control of eating behavior in patients with obesity and diabetes mellitus type 2. Int J Endocrinol. 2020;16(2):145-51.10.22141/2224-0721.16.2.2020.201300
Open DOI Search in Google Scholar Back to article
5. Konturek PC, Konturek JW, Cześnikiewicz-Guzik M, Brzozowski T, Sito E, Konturek SJ. Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol. 2005;56 Suppl 6:5-25.
Search in Google Scholar Back to article
6. Allison KC, Lundgren JD, O’Reardon JP, Martino NS, Sarwer DB, Wadden TA, et al. The Night Eating Questionnaire (NEQ): psychometric properties of a measure of severity of the Night Eating Syndrome. Eat Behav. 2008;9(1):62-72.10.1016/j.eatbeh.2007.03.00718167324
Open DOI Search in Google Scholar Open in PubMed Back to article
7. Kessler RC, Berglund PA, Chiu WT, Deitz AC, Hudson JI, Shahly V, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013;73(9):904-14.10.1016/j.biopsych.2012.11.020362899723290497
Open DOI Search in Google Scholar Open in PubMed Back to article
8. American Psychiatric Association. A. P. & American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5; 2013.10.1176/appi.books.9780890425596
Open DOI Search in Google Scholar Back to article
9. Allison KC, Lundgren JD, O’Reardon JP, Geliebter A, Gluck ME, Vinai P, et al. Proposed diagnostic criteria for night eating syndrome. Int J Eat Disord. 2010;43(3):241-7.10.1002/eat.20693
Open DOI Search in Google Scholar Back to article
10. de Zwaan M, Müller A, Allison KC, Brähler E, Hilbert A. Prevalence and correlates of night eating in the German general population. PLoS One. 2014;14;9(5):e97667.10.1371/journal.pone.0097667402082624828066
Open DOI Search in Google Scholar Open in PubMed Back to article
11. Cassioli E, Rossi E, Squecco R, Baccari MC, Maggi M, Vignozzi L, et al. Reward and psychopathological correlates of eating disorders: The explanatory role of leptin. Psychiatry Res. 2020;290:113071.10.1016/j.psychres.2020.11307132464424
Open DOI Search in Google Scholar Open in PubMed Back to article
12. Skibicka KP, Hansson C, Alvarez-Crespo M, Friberg PA, Dickson SL. Ghrelin directly targets the ventral tegmental area to increase food motivation. Neurosci. 2011;180:129-37.10.1016/j.neuroscience.2011.02.01621335062
Open DOI Search in Google Scholar Open in PubMed Back to article
13. Atalayer D, Gibson C, Konopacka A, Geliebter A. Ghrelin and eating disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:70-82.10.1016/j.pnpbp.2012.08.011352276122960103
Open DOI Search in Google Scholar Open in PubMed Back to article