In vitro evaluation of immunogenic properties of active dressings

Joanna Orlowska; Urszula Kurczewska; Katarzyna Derwinska; Wojciech Orlowski; Daria Orszulak-Michalak

doi:10.2478/cipms-2014-0014

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In vitro evaluation of immunogenic properties of active dressings

Current Issues in Pharmacy and Medical Sciences

Volume 27 (2014): Issue 1 (June 2014)

By: Joanna Orlowska, Urszula Kurczewska, Katarzyna Derwinska, Wojciech Orlowski and Daria Orszulak-Michalak

Open Access

|May 2014

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Abstract

The aim of this study was in vitro evaluation of the level of the immune response in relation to wound dressings composed of alginate, calcium carboxymethylcellulose, and dibutyrylochitin and determination of the direction of response, which will make referring next to the results of in vivo phase possible.

The subject of the experiments was to examine the commercially available, biodegradable alginate dressing, commercially available but not biodegradable dressing constructed from the sodium carboxymethylcellulose, and synthesized in house biodegradable dressing constructed of the dibutyrylchitin. To determine the direction of the immune response, the degree of secretion of pro-inflammatory interleukin (IL-1, IL-6) and antiinflammatory (IL-10) interleukin from murine fibroblasts having contact with the tested dressings (ELISA enzyme linked immunosorbent assay), was tested.

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Articles in this issue

DOI: https://doi.org/10.2478/cipms-2014-0014 | Journal eISSN: 2300-6676 | Journal ISSN: 2084-980X

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Language: English

Page range: 55 - 60

Submitted on: Feb 20, 2014

Accepted on: Mar 10, 2014

Published online: May 30, 2014

Published in print: Jun 1, 2014

Published by: Sciendo

In partnership with: Paradigm Publishing Services

Keywords:

Related subjects:

Pharmacology, toxicology

© 2014 Joanna Orlowska, Urszula Kurczewska, Katarzyna Derwinska, Wojciech Orlowski, Daria Orszulak-Michalak, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 27 (2014): Issue 1 (June 2014)