Review on analgesic effect of co-administrated ibuprofen and caffeine

Andrzej Polski; Regina Kasperek; Karolina Sobotka-Polska; Ewa Poleszak

doi:10.2478/cipms-2014-0003

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Review on analgesic effect of co-administrated ibuprofen and caffeine

Current Issues in Pharmacy and Medical Sciences

Volume 27 (2014): Issue 1 (June 2014)

By: Andrzej Polski, Regina Kasperek, Karolina Sobotka-Polska and Ewa Poleszak

Open Access

|May 2014

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Abstract

Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

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DOI: https://doi.org/10.2478/cipms-2014-0003 | Journal eISSN: 2300-6676 | Journal ISSN: 2084-980X

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Language: English

Page range: 10 - 13

Submitted on: Dec 6, 2013

Accepted on: Feb 14, 2014

Published online: May 30, 2014

Published in print: Jun 1, 2014

Published by: Sciendo

In partnership with: Paradigm Publishing Services

Keywords:

Related subjects:

Pharmacology, toxicology

© 2014 Andrzej Polski, Regina Kasperek, Karolina Sobotka-Polska, Ewa Poleszak, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 27 (2014): Issue 1 (June 2014)