Somatostatin-like immunoreactive primary sensory neurons supplying the porcine adrenal glands in physiological conditions and after adrenalectomy

Gonkowski, Sławomir

doi:10.2478/bvip-2014-0099

Abstract

Retrograde neuronal tracing, using fast blue, in combination with a single-labelling immunofluorescence technique, was applied to determine whether somatostatin (SOM) participates in sensory innervating of the porcine adrenal glands in physiological conditions and after adrenalectomy. In control animals, SOM-like immunoreactive neurons comprised 7.0 ± 0.7% of adrenal gland-projecting cells in dorsal root ganglia (DRG) at neuromeres Th6-7 and 6.5 ± 1.2% at neuromeres Th12-14. After adrenalectomy the percentage of SOM-positive DRG cells considerably increased and attained the level of 44.7 ± 2.5% at neuromeres Th6-7 and 36.6 ± 1.7% at neuromeres Th12-14. The obtained results demonstrate that SOM is not only a neuromediator within sensory neurones supplying the porcine adrenal glands, but also suggest the role of this substance during repairing processes within the nervous system after adrenalectomy.

References

1. Arciszewski M.B., Ekblad E.: Effects of vasoactive intestinal petide and galanin on survival of cultured porcine myenteric neurons. Regul Pept 2005, 125, 185-192.10.1016/j.regpep.2004.08.036
Search in Google Scholar
2. Ballesta J., Bloom S.R., Polak J.M.: Distribution and localization of regulatory peptides. Crit Rev Clin Lab Sci 1985, 22, 185-218.10.3109/10408368509165843
Search in Google Scholar
3. Bossowska A., Crayton R., Radziszewski P., Kmiec Z., Majewski M.: Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder. J Physiol Pharmacol 2009, 60, Suppl 4, 77-81.
Search in Google Scholar
4. Bossowska A., Majewski M.: Tetrodotoxin induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder. Pol J Vet Sci 2012, 15, 355-363.10.2478/v10181-012-0054-y
Search in Google Scholar
5. Bossowska A., Majewski M.: Botulinum toxin type A-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder. Pol J Vet Sci 2012, 15, 345-353.10.2478/v10181-012-0053-z
Search in Google Scholar
6. Brazeau P.: Somatostatin: a peptide with unexpected physiologic activities. Am J Med 1986, 81, 8-13.10.1016/0002-9343(86)90580-2
Search in Google Scholar
7. Chapman V., Dickenson A.H.: The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord. Neuropeptides 1992, 23, 147-152.10.1016/0143-4179(92)90115-D
Search in Google Scholar
8. Corleto V.D., Nasoni S., Panzuto F., Cassetta S., Delle Fave G.: Somatostatin receptor subtypes: basic pharmacology and tissue distribution. Dig Liver Dis 2004, 36, Suppl 1, 8-16.10.1016/j.dld.2003.11.008
Search in Google Scholar
9. Gonkowski S.: Distribution of spinal sensory neurons supplying the adrenal gland in the pig. Folia Histochem Cytobiol 2002, 40, 361-365.
Search in Google Scholar
10. Gonkowski S., Kaminska B., Burlinski P., Kroll A., Calka J.: The influence of drug-resistant ulcerative colitis on the number of cocaine- and amphetamine-regulated transcript peptide-like immunoreactive (CART-LI) mucosal nerve fibres of the descending colon in children. Przegl Gastroenterol 2009, 4, 147-151.
Search in Google Scholar
11. Gonkowski S., Całka J.: Changes in the somatostatin (SOM)- like immunoreactivity within nervous structures of the porcine descending colon under various pathological factors. Exp Mol Pathol 2010, 88, 416-423.10.1016/j.yexmp.2010.01.011
Search in Google Scholar
12. Helyes Z., Than M., Oroszi G., Pinter E., Nemeth J., Keri G., Szolcsányi J.: Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat. Neurosci Lett 2000, 278, 185-188.10.1016/S0304-3940(99)00936-2
Search in Google Scholar
13. Helyes Z., Szabó A., Németh J., Jakab B., Pintér E., Bánvölgyi A., Kereskai L., Kéri G., Szolcsányi J.: Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat. Arthritis Rheum 2004, 50, 1677-1685.10.1002/art.2018415146439
Search in Google Scholar
14. Heym C., Braun B., Shuyi Y., Klimaschewski L., Colombo- Benkmann M.: Immunohistochemical correlation of human adrenal nerve fibres and thoracic dorsal root neurons with special reference to substance P. Histochem Cell Biol 1995, 104, 233-243.10.1007/BF01835156
Search in Google Scholar
15. Majewski M.: Afferent and efferent innervation of porcine ovary-sources and chemical coding. Acta Acad Agricult Tech Olst. 545, Vet 24, Suppl. B, Olsztyn 1997.
Search in Google Scholar
16. Malcangio M.: GDNF and somatostatin in sensory neurones. Curr Opin Pharmacol 2003, 3, 41-45.10.1016/S1471-4892(02)00007-3
Search in Google Scholar
17. Mazzocchi G., Malendowicz L.K., Nussdorfer G.G.: Galanin stimulates corticosterone secretion by isolated rat adrenocortical cells. Biomed Res 1992, 13, 181-184.10.2220/biomedres.13.181
Search in Google Scholar
18. Patel Y.C.: Somatostatin and its receptor family. Front Neuroendocrinol 1999, 20, 157-19810.1006/frne.1999.0183
Search in Google Scholar
19. Niijima A., Winter A.L.: The effect of catecholamines on unit activity in afferent nerves from the adrenal glands. J Physiol 1968, 195, 647-656.10.1113/jphysiol.1968.sp008480
Search in Google Scholar
20. Pidsudko Z.: Immunohistochemical characteristics and distribution of sensory dorsal root ganglia neurons supplying the urinary bladder in the male pig. J Mol Neurosci 2014, 52, 71-81.10.1007/s12031-013-0117-2
Search in Google Scholar
21. Pintér E., Helyes Z., Szolcsányi J.: Inhibitory effect of somatostatin on inflammation and nociception. Pharmacol Ther 2006, 112, 440-456.10.1016/j.pharmthera.2006.04.010
Search in Google Scholar
22. Seybold V.S., Hylden J.L., Wilcox G.L.: Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation. Peptides 1982, 3, 49-54.10.1016/0196-9781(82)90141-3
Search in Google Scholar
23. Shi T.J., Xiang Q., Zhang M.D., Barde S., Kai-Larsen Y., Fried K., Josephson A., Glück L., Deyev S.M., Zvyagin A.V., Schulz S., Hökfelt T.: Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain. Mol Pain 2014, doi: 10.1186/1744-8069-10-12.10.1186/1744-8069-10-12394344824521084
Search in Google Scholar
24. Skobowiat C., Gonkowski S., Calka J.: Phenotyping of sympathetic chain ganglia (SChG) neurons in porcine colitis. J Vet Med Sci 2010, 72, 1269-1274.10.1292/jvms.10-008120460841
Search in Google Scholar
25. Ten Bokum A.M., Holland L.J., Van Hagen P.M.: Somatostatin and somatostatin receptors in the immune system: a review. Eur Cytokine Netw 2000, 11, 161-176.10.1677/joe.0.1610167
Search in Google Scholar
26. Verma N., Rettenmeier A.W., Schmitz-Spanke S.: Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies. Proteomics 2011, 11, 776-793.10.1002/pmic.201000320
Search in Google Scholar
27. Zhang X., Ju G., Elde R., Hökfelt T.: Effect of peripheral nerve cut on neuropeptides in dorsal root ganglia and the spinal cord of monkey with special reference to galanin. J Neurosytol 1993, 22, 342-381.10.1007/BF01195558
Search in Google Scholar
28. Zhou X.F., Livett B.G.: Substance P increases catecholamine secretion from perfused rat adrenal glands evoked by prolonged field stimulation. J Physiol 1990, 425, 321-334.10.1113/jphysiol.1990.sp018105
Search in Google Scholar
29. Zhou X.F., Oldfield B.J., Livett B.G.: Substance P - containing sensory neurons in the rat dorsal root ganglia innervate the adrenal medulla. J Auton Nerv Syst 1991, 33, 247-254. 10.1016/0165-1838(91)90025-X
Search in Google Scholar

Somatostatin-like immunoreactive primary sensory neurons supplying the porcine adrenal glands in physiological conditions and after adrenalectomy

Abstract

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