Skip to main content
Have a personal or library account? Click to login
Cytotoxic effects of the synthetic oestrogens and androgens on Balb/c 3T3 and HepG2 cells Cover

Cytotoxic effects of the synthetic oestrogens and androgens on Balb/c 3T3 and HepG2 cells

Journal of Veterinary Research
Volume 58 (2014): Issue 4 (December 2014)
By: ,  ,   and    
Open Access
|Dec 2014
References

References

  1. 1. Amacher D.E.: Drug-associated mitochondrial toxicity and its detection. Curr Med Chem 2005, 12, 1829-1839.
    Open DOISearch in Google Scholar
  2. 2. Boettcher M., Kosmehl T., Braunbeck T.: Low-dose effects and biphasic effect profiles: is trenbolone a genotoxicant? Mut Res 2011, 723, 152-157.
    Open DOISearch in Google Scholar
  3. 3. Borenfreund E., Puerner J.A.: Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 1985, 24, 119-124.
    Open DOISearch in Google Scholar
  4. 4. Bradford M.M.: A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of dye binding. Anal Biochem 1976, 72, 248-254.
    Open DOISearch in Google Scholar
  5. 5. Caraci F., Pistara V., Corsaro A., Tomasello F., Giuffrida M.L., Soetino M.A., Nicoletti F.: Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures. J Neurosci Res 2011, 89, 592-600.
    Open DOISearch in Google Scholar
  6. 6. Dorn S.B., Bolt H.M., Thevis M., Diel P., Degen G.H.: Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone. Arch Toxicol 2008, 82, 257-263.
    Open DOISearch in Google Scholar
  7. 7. Eisenbrand G., Pool-Zobel B., Baker V., Balls M., Blaauboer B.J., Boobis A., Carere A., Kevekordes S., Lhuguenot J.C., Pieters R., Kleiner J.: Methods of in vitro toxicology. Food Chem Toxicol 2002, 40, 193-236.
    Open DOISearch in Google Scholar
  8. 8. Felty Q., Roy D.: Estrogen, mitochondria, and growth of cancer and non-cancer cells. J Carcinog 2005, 4, 1-18.
    Search in Google Scholar
  9. 9. Fotakis G., Timbrell J.A.: In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 2006, 160, 171-177.
    Open DOISearch in Google Scholar
  10. 10. Giannitrapani L., Soresi M., La Spada E., Cervello M., D’Alessandro N., Montalto G.: Sex hormones and risk of liver tumor. Ann NY Acad Sci 2006, 1089, 228-236.
    Open DOISearch in Google Scholar
  11. 11. Gerets H.H.J., Hanon E., Cornet M., Dhalluin S., Depelchin O., Canning M., Atienzar F.A.: Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: a preliminary study using a multiplexing approach. Toxicol in Vitro 2009, 23, 319-332.
    Open DOISearch in Google Scholar
  12. 12. Ivanova L., Uhlig S.: A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures. Anal Biochem 2008, 379, 16-19.
    Open DOISearch in Google Scholar
  13. 13. Iwasawa A., Ayaki M., Niwano Y.: Cell viability score (CVS) as a good indicator of critical concentration of benzalkonium chloride for toxicity in cultured ocular surface cell lines. Regul Toxicol Pharmacol 2013, 66, 177-183.
    Open DOISearch in Google Scholar
  14. 14. Konac E., Ekmekci A., Barkar V., Yilmaz A., Erbas D.: Effects of diethylstilbestrol in human lymphocytes in vitro: a dose and time-dependent study on genotoxic, cytotoxic and apoptotic effects. Mol Cell Biochem 2005, 276, 45-53.
    Open DOISearch in Google Scholar
  15. 15. Korzeniewski C., Calleawert D.M.: An enzyme-release assay for natural cytotoxicity. J Immunol Methods 1983, 64, 313-320.
    Open DOISearch in Google Scholar
  16. 16. Maier W.E., Herman J.R.: Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol 2001, 34, 53-61.
    Open DOISearch in Google Scholar
  17. 17. Mosmann T.: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods 1983, 65, 55-63.
    Open DOISearch in Google Scholar
  18. 18. Oda T., Tanaka M., Sasaki T.: Cytotoxicity of synthetic estrogen and related compounds in various tumor-derived cells. Biol Pharm Bull 2001, 24, 1142-1144.
    Open DOISearch in Google Scholar
  19. 19. Orlando R., Caruso A., Molinaro G., Motolese M., Matrisciano F., Togna G., Melchiorri D., Nicoletti F., Bruno V.: Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures. Brain Res 2007, 169, 129-136.
    Open DOISearch in Google Scholar
  20. 20. Pandey G., Pandey S.P., Sharma M.: Experimental hepatotoxicity produced by ethinyl estradiol. Toxicol Int 2011, 18, 160-162.
    Open DOISearch in Google Scholar
  21. 21. Pohjala L., Tammela P., Samanta S.K., Yli-Kauhaluoma J., Vuorela P.: Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Anal Biochem 2007, 362, 221-228.
    Open DOISearch in Google Scholar
  22. 22. Radošević K., Tonković T., Slivac I., Kniewald Z., Gaurina Srček V.: Comparison of cytotoxicity induced by 17α- ethynylestradiol and diethylstilbestrol in fish CCO and mammalian CHO-K1 cell lines. Bull Environ Contam Toxicol 2011, 86, 252-257.
    Open DOISearch in Google Scholar
  23. 23. Robertson C.N., Robertson K.M., Padilla G.M.:, O`Brien E.T., Cook J.M., Kim C.S., Fine R.L.: Induction of apoptosis by diethylstilbestrol in hormone insensitive prostate cancer cells. J Natl Cancer Inst 1996, 88, 908-917.
    Open DOISearch in Google Scholar
  24. 24. Schoonen W.G.E.J., Westerink W.M.A., de Roos J.A.D.M., Débiton E.: Cytotoxic effects of 100 reference compounds on HepG2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I Mechanistic assays on ROS, glutathione depletion and calcein uptake. Toxicol in Vitro 2005, 19, 505-516.
    Open DOISearch in Google Scholar
  25. 25. Thorpe K.L., Cummings R.I., Hutchinson T.H., Scolze M., Brighty G., Sumptem J.P.: Relative potencies and combination effects of steroidal estrogens in fish. Environ Sci Technol 2003, 37, 1142-1149.
    Open DOISearch in Google Scholar
  26. 26. van Amsterdam J., Opperhuizen A., Hartgens F.: Adverse health effects of anabolic-androgenic steroids. Regul Toxicol Pharmacol 2010, 57, 117-123.
    Open DOISearch in Google Scholar
  27. 27. Wan L., O`Brien P.: Molecular mechanism of 17α- ethinylestradiol cytotoxicity in isolated rat hepatocytes. Can J Physiol Pharmacol 2014, 92, 21-26.
    Open DOISearch in Google Scholar
  28. 28. Welder A.A., Robertson J.W., Fugate R.D., Melchert R.B.: Anabolic-androgenic steroid induced toxicity in primary neonatal rat myocardial cell cultures. Toxicol Appl Pharmacol 1995, 33, 328-342.
    Open DOISearch in Google Scholar
  29. 29. Woźniak B.: Steroid hormones - properties, application, residues in food of animal origin. Med Weter 2010, 66, 177-181.
    Search in Google Scholar
DOI: https://doi.org/10.2478/bvip-2014-0094 | Journal eISSN: 2450-8608 (formerly 2300-3235)
Journal RSS Feed
Language: English
Page range: 613 - 620
Submitted on: Apr 10, 2014
Accepted on: Oct 14, 2014
Published on: Dec 20, 2014
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Keywords:
synthetic hormones,
cytotoxicity,
Balb/c 3T3,
HepG2
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2014 Maria Minta, Lidia Radko, Sylwia Stypuła-Trębas, Jan Żmudzki, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 58 (2014): Issue 4 (December 2014)
Previous article
Next article