Biophysical parameters of rats’ skin after the administration of methimazole

Marcin Gołyński; Marcin Szczepanik; Krzysztof Lutnicki; Łukasz Adamek; Magdalena Gołyńska; Piotr Wilkołek; Wiesław Sitkowski; Łukasz Kurek; Piotr Dębiak

doi:10.2478/bvip-2014-0049

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Biophysical parameters of rats’ skin after the administration of methimazole

Journal of Veterinary Research

Volume 58 (2014): Issue 2 (June 2014)

By: Marcin Gołyński, Marcin Szczepanik, Krzysztof Lutnicki, Łukasz Adamek, Magdalena Gołyńska, Piotr Wilkołek, Wiesław Sitkowski, Łukasz Kurek and Piotr Dębiak

Open Access

|Jun 2014

Abstract

The paper describes the influence of oral administration of methimazole on biophysical skin parameters. Wistar rats of different sex (220-260 g) were used in the experiment. Biophysical skin parameters, such as transepidermal water loss (TEWL), corneometry, and pH were examined at seven-day intervals. Significant changes in the parameters were observed on the 7^th d of methimazole administration. The changes were observed in both sex but males appeared to be less sensitive in that respect. Changes in the parameters in the females showed rapid mechanisms, which normalised transepidermal water loss and skin hydration, as well as restored skin barrier functions. TEWL, skin hydration, and skin pH measurements allow an early assessment of skin barrier dysfunction after administration of this drug.

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Articles in this issue

DOI: https://doi.org/10.2478/bvip-2014-0049 | Journal eISSN: 2450-8608

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Language: English

Page range: 315 - 319

Submitted on: Sep 4, 2013

Accepted on: Jun 6, 2014

Published on: Jun 17, 2014

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Keywords:

skin,

methimazole,

transepidermal water loss,

Related subjects:

Microbiology and virology,

Life sciences, other,

Medicine,

Veterinary medicine

© 2014 Marcin Gołyński, Marcin Szczepanik, Krzysztof Lutnicki, Łukasz Adamek, Magdalena Gołyńska, Piotr Wilkołek, Wiesław Sitkowski, Łukasz Kurek, Piotr Dębiak, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 58 (2014): Issue 2 (June 2014)