Distribution of ABCB1 Genetic Variants and their Association with Moxifloxacin Pharmacokinetics in Hospitalized Patients with Acute Exacerbation of COPD

Polymorphism	Genotype/Haplotype	n (%)
c.1236C>T (rs1128503)	CC	11 (36.7)
	CA	12 (40.0)
	AA	7 (23.3)
	Minor allele frequency (A)	43.3
c.2677G>T/A (rs2032582)	GG	11 (36.7)
	AG/AA	19 (63.3)
	Minor allele frequency	41.6
c.3435C>T (rs1045642)	CC	10 (33.3)
	CT	13 (43.3)
	TT	7 (23.3)
	Minor allele frequency (T)	45.0
Haplotype	CGC	17 (56.7)
	TTT	13 (43.3)

Table 2.

Moxifloxacin pharmacokinetic parameters according to ABCB1 genotype groups

Polymorphism	Genotype	Cmax (µg/mL), mean ± SD	AUC (mg·h/L), mean ± SD	CL (L/h), mean ± SD
c.1236C>T (rs1128503)	CC	5.88 ± 2.16	37.57 ± 15.20	12.40 ± 5.28
	CA	6.88 ± 3.44	56.24 ± 39.68	9.55 ± 4.51
	AA	4.55 ± 1.46	43.51 ± 19.24	10.96 ± 5.01
c.2677G>T/A (rs2032582)	GG	5.85 ± 2.18	39.99 ± 13.53	11.02 ± 3.53
	AG/AA	6.63 ± 3.43	51.56 ± 40.44	11.38 ± 6.29
c.3435C>T (rs1045642)	CC	6.00 ± 2.20	48.10 ± 31.84	10.67 ± 4.54
	CT	6.57 ± 3.48	47.14 ± 31.88	10.63 ± 4.41
	TT	4.82 ± 1.35	42.72 ± 20.37	11.85 ± 6.74

[i] Values are presented as mean ± SD. Cmax, maximum plasma concentration; AUC, area under the concentration–time curve; CL, clearance.

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DOI: https://doi.org/10.2478/bjmg-2026-0011 | Journal eISSN: 2199-5761 (formerly 1311-0160) | Journal ISSN: 1311-0160

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Language: English

Page range: 17 - 22

Published on: Oct 14, 2026

Published by: Macedonian Academy of Sciences and Arts

In partnership with: Paradigm Publishing Services

Keywords:

ABCB1,

acute exacerbation of chronic obstructive pulmonary disease,

Related subjects:

Basic medical science,

Basic medical science, other

© 2026 O Krstic Nakovska, M Staninova Stojovska, E Mihajloska, Godzo H, A Debreshlioska, A Tatabitovska, D Karkinski, Lj Suturkova, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 29 (2026): Issue 1 (July 2026)