Skip to main content
Have a personal or library account? Click to login
Application of Fluorescence in situ Hybridization in Malignant Hemopathies: First Experience from Albania Cover

Application of Fluorescence in situ Hybridization in Malignant Hemopathies: First Experience from Albania

By: ,  ,   and    
Open Access
|Oct 2026

References

  1. Ngo Sack Françoise, Lontsi Sonkwa Edgard, Chetcha Tchemegni Bernard. Clinical, biological, therapeutic and evolving profile of malignant hemopathies in adults at the central hospital of Yaounde. JMR 2021; ISSN:2395-7565.
  2. Sevgi Gezici Molecular Mechanisms of Immune Checkpoints as an Immunotherapy Tool in Hematological Malignancies. Comprehensive Hematology and Stem Cell Research, 2024, 366–372.
  3. Radhakrishnan Ramchandren, Tarek Jazaerly, Ali M. Gabali. Molecular Diagnosis of Hematopoietic Neoplasms. Clin Lab Med, 2013, 33(4):817–833.
  4. Mi-Ae Jang. Genomic technologies for detecting structural variations in hematologic malignancies. Blood Res, 2024 Feb 13;59(1):1.
  5. T H Lim, S L Tien, P Lim, A S T Lim. The incidence and patterns of BCR/ABL rearrangements in chronic myeloid leukaemia (CML) using fluorescence in situ hybridisation Ann Acad Med Singap 2005 Oct;34(9):533–8. DOI:10.18632/oncotarget.15369 Corpus ID: 3671430.
  6. Bibi Tahira, Muhammad Asif, Samiullah Khan, Abrar Hussain, Muhammad Naeem Shahwani, Arif Malik et.al; Detection of BCR/ABL Fusion Gene by Hematological and Cytogenetical Analysis in Chronic Myeloid Leukemia Patients in Quetta, Pakistan Asian Pac J Cancer Prev 2015;16(9):3793–7 doi: 10.7314/apjcp.2015.16.9.3793.
  7. Hossein Rahimi, Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Amir Hossein Jafarian, Sepideh Shakeri, Seyyede Fatemeh Shams et.al; Cytogenetic Abnormalities with Interphase FISH Method and Clinical Manifestation in Chronic Lymphocytic Leukemia Patients in North-East of Iran Int J Hematol Oncol Stem Cell Res 2017 Jul 1;11(3):217–224.
  8. V. Buccheri, W. Barreto, L. Fogliatto, M. Capra, Mariana Marchiani, V. Rocha Prognostic and therapeutic stratification in CLL: focus on 17p deletion and p53 mutation Annals of Hematology 12 October 2018 DOI: 10.1007/s00277-018-3503-6 Corpus ID: 52975190.
  9. Patricia T Greipp, Stephanie A Smoley, David S Viswanatha, Lori S Frederick, Kari G Rabe, Ruchi G Sharma, et.al; Patients with chronic lymphocytic leukaemia and clonal deletion of both 17p13.1 and 11q22.3 have a very poor prognosis Br J Haematol 2013 Nov;163(3):326–33. doi: 10.1111/bjh.12534.
  10. Elias Campo, Florence Cymbalista, Paolo Ghia, Ulrich Jäger, Sarka Pospisilova, Richard Rosenquist et.al; TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics Haematologica 2018 Nov 15;103(12):1956–1968. doi: 10.3324/haematol.2018.187583.
  11. Marie-France Gagnon, Holly E Berg, Reid G Meyer, William R Sukov, Daniel L Van Dyke, Robert B Jenkins et.al; Typical, atypical and cryptic t(15;17) (q24;q21) (PML::RARA) observed in acute promyelocytic leukemia: A retrospective review of 831 patients with concurrent chromosome and PML::RARA dual-color dual-fusion FISH studies Genes Chromosomes Cancer 2022 Oct;61(10):629–634. doi: 10.1002/gcc.23070.
  12. Maedeh Mohebnasab, Peng Li, Bo Hong, Jennifer Dunlap, Elie Traer, Guang Fan et. al; Cytogenetically Cryptic Acute Promyelocytic Leukemia: A Diagnostic Challenge Int J Mol Sci 2023 Aug 22;24(17):13075. doi: 10.3390/ijms241713075.
  13. Rimvydas Norvilas, Vaidas Dirse, Ruta Semaskeviciene, Orinta Mickeviciute, Egle Gineikiene et, al: Low incidence of ABL-class and JAK-STAT signaling pathway alterations in uniformly treated pediatric and adult B-cell acute lymphoblastic leukemia patients using MRD risk-directed approach - a population-based study BMC Cancer, 2021 Mar 29;21(1):326. doi: 10.1186/s12885-020-07781-6.
  14. Heim S. Cytogenetic findings in primary and secondary MDS. Leuk Res. 1992;16(1):43–6. doi: 10.1016/0145-2126(92)90098-r. PMID: 1732669
  15. Matteo Zampini, Elena Riva, Luca Lanino, Elisabetta Sauta, Rita Antunes Dos Reis et.al, Characterization and Clinical Implications of p53 Dysfunction in Patients With Myelodysplastic Syndromes J Clin Oncol 43, 2069–2083(2025), Volume 43, Number DOI: 10.1200/JCO-24-02394.
  16. Ugo Testa, Germana Castelli, Elvira Pelosi Clinical and Biological Insights into Myelodysplastic Neoplasms Associated with Deletions of Chromosome 5q Region Hematol. Rep. 2025, 17(6), 67; https://doi.org/10.3390/hematolrep17060067.
  17. Hatice Deniz Gur, Sa A. Wang, Zhenya Tang, Shimin Hu, Shaoying Li et.al; Clinical significance of isolated del(7p) in myeloid neoplasms Leukemia Research, Volume 55, April 2017, Pages 18–22 January 2017 https://doi.org/10.1016/j.leukres.2017.01.016.
  18. Sandra Huber, Stephan Hutter, Constance Baer, Manja Meggendorfer, Gregor Hoermann, Wolfgang Kern, et.al; Two ways to complex karyotype in MDS—the role of del(5q) and TP53 Blood (2024) 144 (Supplement 1): 1836. https://doi.org/10.1182/blood-2024-201270.
  19. Manoela M Ortega, Monica Barbosa De Melo, Carmino A. Souza, Lima Carmen S. Passos Lima, P53 gene deletion in multiple myeloma June 2003 Revista Brasileira de Hematologia e Hemoterapia 25(2) DOI: 10.1590/S1516-84842003000200014 .
  20. M. Martello, A. Poletti, E. Borsi, V. Solli, L. Dozza, S. Barbato, et al Clonal and subclonal TP53 molecular impairment is associated with prognosis and progression in multiple myeloma Blood Cancer J 2022 Jan 26;12(1):15. doi: 10.1038/s41408-022-00610-y.
  21. Seiichiro Katagiri, Daigo Akahane, Kunihiko Takeyama, Norihide Sato, Nobuyuki Takayama, Jun Ando, et al. TP53 deletion is associated with poor survival of adult ALK-positive ALCL patients receiving CHOP-based chemotherapy Annals of Hematology (2025) 104:1801–1806 https://doi.org/10.1007/s00277-025-06297-y.
DOI: https://doi.org/10.2478/bjmg-2026-0006 | Journal eISSN: 2199-5761 (formerly 1311-0160) | Journal ISSN: 1311-0160
Language: English
Page range: 33 - 38
Published on: Oct 14, 2026
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services

© 2026 D Roko, A Babameto-Laku, A Perolla, E Calliku, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution 4.0 License.