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Molecular and Immunohistochemical Biomarkers in Colorectal Carcinoma - A Single Center Study Cover

Molecular and Immunohistochemical Biomarkers in Colorectal Carcinoma - A Single Center Study

Open Access
|Oct 2025

Figures & Tables

Figure 1.

KRAS/NRAS mutations
KRAS/NRAS mutations

Figure 2.

BRAF mutations
BRAF mutations

Figure 3.

MMR status
MMR status

Figure 4.

HER2 expression in metastatic cases
HER2 expression in metastatic cases

Figure 5.

PDL-1 expression in metastatic cases
PDL-1 expression in metastatic cases

Figure 6.

Immunohistochemical analysis showing HER2 score 3+ and PDL-1 score >50%
Immunohistochemical analysis showing HER2 score 3+ and PDL-1 score >50%

Figure 7.

HER2 distribution by score
HER2 distribution by score

Figure 8.

PDL-1 distribution by score
PDL-1 distribution by score

Distribution of the patients according to postoperative Stage

variablen(%)
STAGE
04(2,62)
I9(5,92)
II A35(23,02)
II B2(1,32)
II C2(1,32)
III A1(0,66)
III B54(35,53)
III C32(21,05)
IV A7(4,61)
IV C6(3,95)

Demographic characteristics of the patients

variablen (%)

Gender
  female54 (35.53)
  male98 (64.47)

Age groups
  ≤50 years15 (9.87)
  >50 years137 (90.13)

Age/years
  (mean ± SD)( min-max)(68.37 ± 11.3)(34 – 89)
  median (IQR)75.5(62 – 11.32)

Immunohistochemical stains

Antibody(rtu)CloneProducerType of signal
MLH1M1Ventana, USAnuclear
PMS2A16-4Ventana, USAnuclear
MSH2G219-1129Ventana, USAnuclear
MSH6SP93Ventana, USAnuclear
PDL1SP263Ventana, USAmembranous
HER24B5Ventana, USAmembranous
Language: English
Published on: Oct 8, 2025
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2025 B Krsteska, V Filipovski, K Kubelka-Sabit, Dz Jasar, N Velickova, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.