Figure 1.
TLR4 gene variation distribution status in cases with and without scarring
| Variation Status in TLR4 gene | Renal scar (+), n(%) | Renal scar (-), n(%) | p |
|---|---|---|---|
| Heterozygous | 17 (65.4) | 20 (87) | >0.05 |
| Compound heterozygous | 9 (34.6) | 2 (8.7) | <0.05 |
| Normal | 0 (0) | 1 (3) | >0.05 |
| c.958T>C p.Ser320Pro in Ex4 | 25 (96.2) | 22 (95.7) | >0.05 |
| c.942A>G p.Lys314 in Ex4 (rs56070048) | 2 (7.7) | 0 (0) | >0.05 |
| c.776A>G p.Asp259Gly in Ex4 (rs4986790) | 2 (7.7) | 1 (4.3) | >0.05 |
| c.1076C>T p.Thr359Ile in Ex4 (rs4986791) | 4 (15.4) | 1 (4.3) | >0.05 |
| c.896A<G p.Asp299Gly in Ex3 (rs4986790) | 2 (7.7) | 0 (0) | >0.05 |
| c.1196C>T p.Thr399Ile rs4986791 in EX3 | 1 (4.3) | 0 (0) | >0.05 |
| c.315C>T p.Pro105 rs5030711 in Ex4 | 0 (0) | 1 (4.3) | >0.05 |
| c.1078C>T p.Ser360Pro in Ex3 | 1 (4.3) | 0 (0) | >0.05 |
Comparison of anthropometric characteristics and blood values of cases with and without scarring
| Renal scar (+) (n=26) | Renal scar (-) (n= 23) | p | |
|---|---|---|---|
| Age, year (Mean±SD) | 10.5±4.37 | 9.91±3.43 | 0.3 |
| Gender (boy/girl) (n) | 8/18 | 6/17 | 0,9 |
| Systolic blood pressure, mmHg (Mean±SD) | 114.84±12.05 | 93.91±6.74 | 0.000 |
| Diastolic blood pressure, mmHg (Mean±SD) | 68.88±8.86 | 54.26±6.29 | 0.000 |
| Serum urea (mg/dL) (Mean±SD) | 25.33±6.87 | 24.22±6.46 | 0.667 |
| Serum creatinine (mg/dL) (Mean±SD) | 0.56±0.19 | 0.37±0.13 | 0.000 |
| e-GFR (mL/min/1.73m2) (Mean±SD) | 108.72±23.54 | 121.53±32.35 | 0.11 |