Figure 1.
Participant characteristics (N=268) in comparison with high income countries (T21RS data)
| Count (N) | Percent (%) | Count (N) | Percent (%) | ||
|---|---|---|---|---|---|
| CROATIA | HIC | P – value* | |||
| AGE, mean (SD) | 8.7 (8.1) | 33.5 (19.1) | <0.001 | ||
| 0–1 | 49 | 18.3 | |||
| 2–4 | 55 | 20.5 | |||
| 5–12 | 103 | 38.4 | |||
| 13–19 | 32 | 11.9 | |||
| >20 | 29 | 10.9 | |||
| GENDER | 0.773 | ||||
| Female | 123 | 45.9 | 355 | 44.7 | |
| Male | 145 | 54.1 | 436 | 54.9 | |
| Other | 0 | 0.0 | 3 | 0.4 | |
| BMI, mean (SD) | 19.1 (6.2) | not reported | |||
| <18.5 | 163 | 60.8 | |||
| 18.5–25 | 56 | 20.9 | |||
| 25–30 | 27 | 10.1 | |||
| >30 | 14 | 5.3 | |||
| Missing | 8 | 2.9 | |||
| TYPE OF TRISOMY 21 | <0.001 | ||||
| Full/standard | 201 | 74.7 | 274 | 88.4 | |
| Mosaic | 11 | 4.1 | 29 | 9.4 | |
| Translocation | 17 | 6.3 | 5 | 1.6 | |
| Don’t know | 39 | 14.9 | 2 | 0.6 | |
| LEVEL OF INTELLECTUAL DISABILITY | <0.001 | ||||
| Borderline/mild | 91 | 34.0 | 126 | 18.3 | |
| Moderate | 93 | 34.7 | 404 | 58.7 | |
| Severe/profound | 19 | 7.0 | 158 | 23.0 | |
| Don’t know | 65 | 24.3 | 0 | 0.0 | |
| LIVING SITUATION | <0.001 | ||||
| Living at home with family | 256 | 95.5 | 425 | 55.5 | |
| Living at home with caregivers | 2 | 0.8 | 10 | 1.3 | |
| Residential care facility | 6 | 2.2 | 181 | 23.6 | |
| Other | 4 | 1.5 | 149 | 19.5 | |
Medical information (N=268)
| Count (N) | Percent (%) | |
|---|---|---|
| COMORBIDITIES | ||
| Allergy | 23 | 8.6 |
| Blood cancer | 2 | 0.8 |
| Celiac disease | 8 | 2.9 |
| Chronic lung disease | 3 | 1.2 |
| Congenital heart defect | 111 | 41.4 |
| Epilepsy/seizures | 7 | 2.6 |
| Gastroesophageal reflux | 6 | 2.2 |
| Immune-compromised | 10 | 3.7 |
| Obesity | 11 | 4.1 |
| Obstructive sleep apnoea | 5 | 1.9 |
| Thyroid disorder | 52 | 19.5 |
| Other | 8 | 2.9 |
| No comorbidities | 22 | 8.2 |
| Congenital heart defect type | ||
| Aortic stenosis | 2 | 1.8 |
| Atrial septal defect | 24 | 21.6 |
| Atrioventricular septal defect | 36 | 32.4 |
| Combined heart defect | 10 | 9.0 |
| Ductus arteriosus persistens | 6 | 5.4 |
| Tetralogy Fallot | 2 | 1.8 |
| Ventricular septal defect | 22 | 19.8 |
| Don’t know | 9 | 8.2 |
| SUPPLEMENTATION | ||
| No | 187 | 69.8 |
| Yes, one | 47 | 17.5 |
| Yes, two or more | 34 | 12.7 |
| Supplements | ||
| Multivitamins | 28 | 29.8 |
| Omega 3 | 10 | 10.6 |
| Probiotics | 32 | 34.0 |
| Vitamin D | 24 | 25.6 |
Challenges for parents during COVID-19, impact on the child and medical support for parents (N=268)
| Count (N) | Percent (%) | |
|---|---|---|
| NUMBER OF CHALLENGES | ||
| 0 | 124 | 46.3 |
| 1 | 72 | 26.9 |
| 2 | 58 | 21.6 |
| ≥3 | 14 | 5.2 |
| Challenges | ||
| Cancelled therapy | 20 | 13.9 |
| Cancelled therapy + lack of social activity | 22 | 15.3 |
| Cancelled therapy + lack of social activity + psychological problems | 9 | 6.3 |
| Lack of social activity | 32 | 22.2 |
| Lack of social activity + psychological problems | 24 | 16.7 |
| Psychological problems | 16 | 11.1 |
| Other | 21 | 14.5 |
| IMPACT ON THE CHILD | ||
| No impact | 125 | 46.6 |
| Emotional well-being | 32 | 11.9 |
| Physical health | 10 | 3.7 |
| Physical health + emotional well-being | 11 | 4.2 |
| N/A | 90 | 33.6 |
| MEDICAL SUPPORT FOR PARENTS | ||
| Not satisfied | 34 | 12.7 |
| Slightly satisfied | 30 | 11.2 |
| Moderately satisfied | 58 | 21.7 |
| Very satisfied | 48 | 17.9 |
| N/A | 98 | 36.6 |
Clinical presentation of COVID-19, treatment and vaccination (N=268)
| Count (N) | Percent (%) | |
|---|---|---|
| SARS-CoV-2 | ||
| − | 132 | 49.3 |
| + | 136 | 50.7 |
| NUMBER OF SYMPTOMS | ||
| 0 | 13 | 9.5 |
| 1 | 60 | 44.2 |
| 2 | 40 | 29.4 |
| ≥3 | 23 | 16.9 |
| Symptoms | ||
| Cough | 6 | 4.8 |
| Runny nose | 9 | 7.3 |
| Fever ≥38°C | 45 | 36.6 |
| Fever ≥38°C + cough | 21 | 17.1 |
| Fever ≥38°C + shortness of breath | 4 | 3.3 |
| Fever ≥38°C + muscle or joint pain | 4 | 3.3 |
| Fever ≥38°C + nasal signs | 6 | 4.9 |
| Fever ≥38°C + cough + shortness of breath | 9 | 7.3 |
| Fever ≥38°C + cough + nasal signs | 8 | 6.5 |
| Other | 11 | 8.9 |
| TREATMENT | ||
| At home | 130 | 95.6 |
| In hospital | 6 | 4.4 |
| MEDICATIONS | ||
| Azithromycin | 7 | 5.1 |
| Natural remedies | 17 | 12.5 |
| Paracetamol | 49 | 36.1 |
| Paracetamol + azithromycin | 4 | 2.9 |
| Paracetamol + natural remedies | 7 | 5.1 |
| Nothing | 47 | 34.6 |
| Other | 5 | 3.7 |
| MEDICAL COMPLICATIONS DUE COVID-19 | ||
| − | 130 | 95.6 |
| + | 6 | 4.4 |
| VACCINATION AGAINST SARS-CoV-2 | ||
| − | 238 | 88.8 |
| + | 30 | 11.2 |