Frequency of allelic and genotypic polymorphisms in UGT1A1, SLCO1B1, SLCO1B3 and GSTP1 genes in case and control groups
| Genotype frequency n (%) | Allele frequency n (%) | ||||||
|---|---|---|---|---|---|---|---|
| A/A | A/G | G/G | Total | A | G | Total |
| IH | 49 (92.4) | 2(3.8) | 2(3.8) | 53 (100) | 100 (94) | 6(6) | 106(100) |
| Prolonged jaundice | 21 (77.8) | 6 (22.2) | 0 | 27(100) | 48 (89) | 6(11) | 54(100) |
| Control | 35 (92.1) | 3 (7.9) | 0 | 38(100) | 73 (96) | 3(4) | 76(100) |
| P | 0.14 | 0.26 | |||||
| A/A | A/G | G/G | Total | A | G | Total |
| IH | 17(27.8) | 35 (57.3) | 9(14.9) | 61(100) | 69(57) | 53 (43) | 122(100) |
| Prolonged jaundice | 7(25) | 13 (46.4) | 8 (28.6) | 28(100) | 27(48) | 29 (52) | 56(100) |
| Control | 19 (46.3) | 16 (39) | 6(14.7) | 41(100) | 54(66) | 28 (34) | 82(100) |
| P | 0.09 | 0.11 | |||||
| C/C | C/A | A/A | Total | C | A | Total |
| IH | 47 (77) | 13 (21.3) | 1 (1.7) | 61(100) | 107 (88) | 15 (12) | 122(100) |
| Prolonged jaundice | 20 (71.4) | 7(25) | 1 (3.6) | 28(100) | 47 (84) | 9(16) | 56(100) |
| Control | 32 (82) | 7(18) | 0 | 39(100) | 71(91) | 7(9) | 78 (100) |
| P | 0.59 | 0.46 | |||||
| T/C | C/C | Total | T | C | Total | |
| IH | 38 (62.3) | 21 (34.4) | 2 (3.3) | 61(100) | 97(80) | 25 (20) | 122(100) |
| Prolonged jaundice | 21 (75) | 6(21.4) | 1 (3.6) | 28(100) | 48 (86) | 8 (14) | 56(100) |
| Control | 31(75.6) | 9(21.9) | 1 (2.5) | 41(100) | 71(87) | 11(13) | 82(100) |
| P | 0.27 | 0.35 | |||||
| G/G | G/C | C/C | Total | G | C | Total |
| IH | 61 (100) | 0 | 0 | 61(100) | 122(100) | 0 | 122(100) |
| Prolonged jaundice | 28(100) | 0 | 0 | 28(100) | 56(100) | 0 | 56(100) |
| Control P | 40 (100) | 0 | 0 | 40 (100) | 80 (100) | 0 | 80(100) |
| T/T | T/G | G/G | Total | T | G | Total |
| IH | 2(3.4) | 13 (22.4) | 43 (74.2) | 58(100) | 17(15) | 99 (85) | 116(100) |
| Prolonged jaundice | 0 | 6(21.4) | 22 (78.6) | 28(100) | 6(11) | 50 (89) | 56(100) |
| Control | 0 | 3 (7.5) | 37(92.5) | 40(100) | 3(4) | 77 (96) | 80(100) |
| P | 0.20 | 0.03 | |||||
| c/c | C/G | G/G | Total | C | G | Total |
| IH | 46 (75.4) | 11(18) | 4 (6.6) | 61(100) | 103 (94) | 19(16) | 122(100) |
| Prolonged jaundice | 19(67.8) | 7(25) | 2 (7.2) | 28 (100) | 45(80) | 11(20) | 56(100) |
| Control | 33 (80.5) | 7(17) | 1 (2.5) | 41 (100) | 73 (89) | 9(11) | 82(100) |
| P | 0.49 | 0.36 | |||||
| C/C | C/T | T/T | Total | C | T | Total |
| IH | 17 (27.8) | 29 (47.5) | 15 (24.7) | 61(100) | 63 (52) | 59 (48) | 122(100) |
| Prolonged jaundice | 6 (21.4) | 13 (46.4) | 9 (32.2) | 28 (100) | 25 (45) | 31(55) | 56(100) |
| Control | 4 (9.7) | 21(51.2) | 16(39.1) | 41 (100) | 29 (35) | 53 (65) | 82(100) |
| P | 0.07 | 0.07 | |||||
| GSTP1 | |||||||
| A/A | A/G | G/G | Total | A | G | Total |
| IH | 28 (50.9) | 18 (32.7) | 9(16.4) | 55 (100) | 74(67) | 36 (33) | 110(100) |
| Prolonged jaundice | 12(42.8) | 13 (46.4) | 3 (10.8) | 28(100) | 37(66) | 19 (34) | 56(100) |
| Control | 18(45) | 19(47.5) | 3 (7.5) | 40 (100) | 55(69) | 25 (31) | 80 (100) |
| c | 0.74 | 0.94 | |||||
| C/C | C/T | T/T | Total | C | T | Total |
| IH | 48 (87.3) | 7(12.7) | 0 | 55 (100) | 103 (94) | 7(6) | 110(100) |
| Prolonged jaundice | 21 (75) | 7(25) | 0 | 28(100) | 49(88) | 7(12) | 56(100) |
| Control | 29 (72.5) | 11(27.5) | 0 | 40 (100) | 69(86) | 11(14) | 80(100) |
| P | 0.15 | 0.19 | |||||
Demographic characteristics of the study population
| Idiopathic Hyperbilirubinemia (n:61) | Prolonged jaundice (n:28) | Control (n:41) | P | |
|---|---|---|---|---|
| Gestational age (weeks, mean± SD) | 38.1 ± 1.0 | 38.5 ± 1.0 | 38.8 ±1.0 | >0.05 |
| Birth weight (g, mean ± SD) | 3145 ±397 | 3154 ±390 | 3322 ±416 | >0.05 |
| Gender (Male/Female) | 30/31 | 13/15 | 20/21 | >0.05 |
| Peak STB* level (mg/dl) | 19.3 ± 1.9 | - | 7.1 ±2.4 | 0.0001 |
| Peak time of STB (days) | 5.2 ±1.9 | - | 5.1 ± 1.5 | >0.05 |
| Feeding pattern (breast milk/breast milk+formula) | 56/5 | 26/2 | 37/4 | >0.05 |
Peak bilirubin levels and peak time of hyperbilirubinemia in the idiopathic hyperbilirubinemia group according to genotypic distributions
| Genotype distribution | P | |||
|---|---|---|---|---|
| G/G | AJG | G/G | |
| Mean peak bilirubin levels (mg/dL) | 19.4 ±2.1 | 20 ±2.8 | 19.7 ±1.3 | 0.87 |
| Peak time of hyperbilirubinemia (day) | 5.1 ± 1.9 | 6 ± 1.4 | 8.5 ±3.5 | 0.06 |
| A/A | AJG | G/G | |
| Mean peak bilirubin levels (mg/dL) | 18.8 ± 1.2 | 19.5 ±2.3 | 19.2 ±1.5 | 0.42 |
| Peak time of hyperbilirubinemia (day) | 5.0 ±2.0 | 5.2 ±2.2 | 5.4 ± 1.1 | 0.89 |
| C/C | C/A | A/A | |
| Mean peak bilirubin levels (mg/dL) | 19.2 ± 1.6 | 19.9 ± 2.9 | 17 ±0 | 0.28 |
| Peak time of hyperbilirubinemia (day) | 5.1 ± 1.9 | 5.6 ± 2.4 | 5.0 ±0.0 | 0.74 |
| T/T | T/C | C/C | |
| Mean peak bilirubin levels (mg/dL) | 19.3 ± 2.2 | 19.3 ± 1.5 | 18.1 ±0.9 | 0.67 |
| Peak time of hyperbilirubinemia (day) | 5.5 ±2.1 | 4.7 ± 1.8 | 4.5 ±2.1 | 0.27 |
| G/G | G/C | C/C | |
| Mean peak bilirubin levels (mg/dL) | 19.4 ± 1.5 | - | - | - |
| Peak time of hyperbilirubinemia (day) | 5.2 ± 1.8 | - | - | - |
| T/T | G/T | G/G | |
| Mean peak bilirubin levels (mg/dL) | 20.3 ±2.1 | 18.8 ± 1.1 | 19.4 ±2.2 | 0.49 |
| Peak time of hyperbilirubinemia (day) | 6.0 ± 1.4 | 4.8 ±2.1 | 5.2 ±2.0 | 0.69 |
| C/C | C/G | G/G | |
| Mean peak bilirubin levels (mg/dL) | 19.3 ± 2.0 | 18.9 ± 1.4 | 19 ±2.4 | 0.77 |
| Peak time of hyperbilirubinemia (day) | 5.3 ± 2.2 | 4.9 ± 0.9 | 5.2 ±2.6 | 0.84 |
| C/C | C/T | T/T | |
| Mean peak bilirubin levels (mg/dL) | 19.4 ± 2.3 | 19.8 ± 2.0 | 18.7 ± 1.1 | 0.19 |
| Peak time of hyperbilirubinemia (day) | 5.0 ± 1.8 | 5.5 ± 2.3 | 4.8 ± 1.5 | 0.47 |
| A/A | AJG | G/G | |
| Mean peak bilirubin levels (mg/dL) | 19.8 ±2.1 | 19.2 ± 1.8 | 18.5 ± 1.6 | 0.25 |
| Peak time of hyperbilirubinemia (day) | 5.5 ± 1.9 | 5.3 ± 2.4 | 4.4 ± 1.3 | 0.40 |
| C/C | C/T | T/T | |
| Mean peak bilirubin levels (mg/dL) | 19.4 ± 2.0 | 18.9 ± 1.4 | - | 0.50 |
| Peak time of hyperbilirubinemia (day) | 5.2 ± 1.9 | 5.2 ± 2.6 | - | 0.98 |