Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients Cover

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Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients

Balkan Journal of Medical Genetics

Volume 26 (2023): Issue 1 (July 2023)

By: I Bozkurt, T Gözler, I Yüksel, K Ulucan and KN Tarhan

Open Access

|Jul 2023

Figures & Tables

Distributions of CYP1A2 rs2069514 and rs762551 polymorphisms by ICU and Mortality Status

			Intensive Care		Mortality
			Non = 35	Yesn = 25	Aliven = 47	Exn = 13
CYP1A2 (rs2069514)	Genotype n (%)	AA	2 (5.7)	4 (16.0)	3 (6.4)	3 (23.1)
		AG	3 (8.6)	11 (44.0)	7 (14.9)	7 (53.8)
		GG	30 (85.7)	10 (40.0)	37 (78.7)	3 (23.1)
	Allele frequency, n (%)	A	11 (14.8)	19 (38.0)	13 (13.8)	13 (50.0)
	Allele frequency, n (%)	G	63 (85.2)	31 (62.0)	81 (86.2)	13 (50.0)
CYP1A2 (rs762551)	Genotype n (%)	AA	16 (45.7)	5 (20.0)	18 (38.3)	3 (23.1)
		AC	10 (28.6)	5 (20.0)	12 (25.5)	3 (23.1)
		CC	9 (25.7)	15 (60.0)	17 (36.2)	7 (53.8)
	Allele frequency, n (%)	A	42 (59.9)	15 (30,0)	48 (51.1)	9 (34.6)
	Allele frequency, n (%)	C	28 (40.1)	35 (70.0)	46 (48.9)	17 (65.4)

Distribution of age, gender, additional disease, and symptom information of patients with COVID-19 (n=60)

Variables		N (%)
Age	<65	29 (48.3)
Age	≥65	31 (51.7)
Gender	Male	32 (53.3)
Gender	Female	28 (46.7)
Chronic Disease	No	38 (63.3)
Chronic Disease	Yes	22 (36.7)
Cardiovascular Disease	No	47 (78.3)
Cardiovascular Disease	Yes	13 (21.7)
Respiratory Distress	No	39 (65.0)
Respiratory Distress	Yes	21 (35.0)
Neurological Disease	No	54 (90.0)
Neurological Disease	Yes	6 (10.0)
Fever	No	50 (83.3)
Fever	Yes	10 (16.7)
Fatigue	No	33 (55.0)
Fatigue	Yes	27 (45.0)
Cough	No	37 (61.7)
Cough	Yes	23 (38.3)
Loss of Taste and Smell	No	50 (83.3)
Loss of Taste and Smell	Yes	10 (16.7)
Diarrhea	No	59 (98.3)
Diarrhea	Yes	1 (1.7)
Nausea Vomiting	No	56 (93.3)
Nausea Vomiting	Yes	4 (6.7)
Intubated	No	45 (75.0)
Intubated	Yes	15 (25.0)
Expectoration	No	60 (100.0)
Expectoration	Yes	0 (0,0)
Frosted Glass Image	No	40 (66.7)
Frosted Glass Image	Yes	20 (33.3)
Mortality	Alive	47 (78.3)
Mortality	Ex	13 (21.7)
Intensive Care	Alive	35 (58.3)
Intensive Care	Passed away	25 (41.7)

Comparison of patients with and without intensive care

Intensive Care Hospitalization
Parameters, n (%)	Yesn = 25	Non = 35	p
Age
<65	5 (17.2)	24 (82.8)	<0.001^a
≥65	20 (64.5)	11 (35.5)	<0.001^a
Gender
Male	15 (60.0)	17 (48.6)	0.382^a
Woman	10 (40.0)	18 (51.4)	0.382^a
Chronic Disease
No	10 (26.3)	28 (73.7)	0.002^a
Yes	15 (68.2)	7 (31.8)	0.002^a
Cardiovascular Disease
No	15 (31.9)	32 (68.1)	0.004^a
Yes	10 (76.9)	3 (23.1)	0.004^a
Respiratory Distress
No	5 (12.8)	34 (87.2)	<0.001^a
Yes	20 (95.2)	1 (4.8)	<0.001^a
Neurological Disease
No	19 (35.2)	35 (64.8)	0.004^b
Yes	6 (100.0)	0 (0,0)	0.004^b
Fever
No	20 (40.0)	30 (60.0)	0.558^b
Yes	5 (50.0)	5 (50.0)
Cough
No	13 (35.1)	24 (64.9)	0.193^a
Yes	12 (52.2)	11 (47.8)	0.193^a
Weakness
No	10 (30.3)	23 (69.7)	0.048^a
Yes	15 (55.6)	12 (44.4)	0.048^a
Loss of Taste and Smell
No	25 (50.0)	25 (50.0)	0.003^b
Yes	0 (0,0)	10 (100.0)	0.003^b
Diarrhea
No	24 (40.7)	35 (59.3)	0.417^b
Yes	1 (100.0)	0 (0,0)	0.417^b
Nausea Vomiting
No	21 (37.5)	35 (62.5)	0.026^b
Yes	4 (100.0)	0 (0,0)	0.026^b
Intubated
No	10 (22.2)	35 (77.8)	<0.001^a
Yes	15 (100.0)	0 (0,0)	<0.001^a
Frosted Glass Image
No	6 (15.0)	34 (85.0)	<0.001^a
Yes	19 (95.0)	1 (5.0)	<0.001^a
CYP1A2 rs2069514
GG	10 (25.0)	30 (75.0)	<0.001^a
AA+AG	15 (75.0)	5 (25.0)	<0.001^a
CYP1A2 rs762551
AA	5 (23.8)	16 (76.2)	0.040^a
CC+CA	20 (51.3)	19 (48.7)	0.040^a
CYP1A2 Genotype
1A/1A	5 (55.6)	4 (44.4)	<0.001^a
1A/1F+1F/1F	5 (16.1)	26 (83.9)
1C/1F	4 (100.0)	0 (0,0)
1A/1C+1C/1C	11 (68.8)	5 (31.3)

Multivariate Logistic Regression Results on ICU Admission for Various Variables_

	Multivariate
Variables	OR (95%CI)	p
CYP1A2 Genotype (ref: 1A/1A+1F/1F)	5.23 (1.22–22.36)	0.025
Chronic disease (ref: none)	4.68 (1.14–19.15)	0.032
Fatigue (ref: none)	0.92 (0.21–3.94)	0.920
Age (ref: <65)	5.17 (1.26–21.14)	0.022
	R² =0.48 −2 Log likelihood =55.201

DOI: https://doi.org/10.2478/bjmg-2023-0005 | Journal eISSN: 2199-5761

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Language: English

Page range: 35 - 42

Published on: Jul 31, 2023

Published by: Macedonian Academy of Sciences and Arts

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

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© 2023 I Bozkurt, T Gözler, I Yüksel, K Ulucan, KN Tarhan, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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