Figure 1.
Figure 2.
Association of rs35006907 with DCM_
| SNP | Function | Population | MAF | Genotype | Model | P-Value | OR (95%CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| CC | CA | AA | Additive | 0.004 | 0.78 (0.66–0.93) | ||||
| rs35006907 | Enhancer | Control | 0.44 | 194 | 280 | 126 | Dominant | 0.16 | 0.84 (0.66–1.07) |
| C>A | DCM | 0.38 | 192 | 268 | 69 | Recessive | 0.0005 | 0.56 (0.41–0.78) | |
Baseline characteristics of population
| Variable | DCM (n=529) | Control (n=600) | P Value |
|---|---|---|---|
| Age | 56.6±10.5 | 55.8±9.6 | 0.15 |
| Gender (males/females) | 175/354 | 210/390 | 0.5 |
| SBP (mmHg) | 123±28 | 126±26 | 0.054 |
| DBP (mmHg) | 82±11 | 81±13 | 0.09 |
| IVSD (mm), mean±SD | 9.7±1.7 | 9.8±2.6 | 0.3 |
| LVEDD (mm), mean±SD | 65.3±8.4 | 46.04.2 | <0.001 |
| LVPWD (mm), mean±SD | 9.6±1.4 | 9.2±1.6 | <0.001 |
| LVEF (%) | 35.1±12.5 | 61.5±7.7 | <0.001 |