Table 1.
Baseline characteristics of population
| Variable | DCM (n=529) | Control (n=600) | P Value |
|---|---|---|---|
| Age | 56.6±10.5 | 55.8±9.6 | 0.15 |
| Gender (males/females) | 175/354 | 210/390 | 0.5 |
| SBP (mmHg) | 123±28 | 126±26 | 0.054 |
| DBP (mmHg) | 82±11 | 81±13 | 0.09 |
| IVSD (mm), mean±SD | 9.7±1.7 | 9.8±2.6 | 0.3 |
| LVEDD (mm), mean±SD | 65.3±8.4 | 46.04.2 | <0.001 |
| LVPWD (mm), mean±SD | 9.6±1.4 | 9.2±1.6 | <0.001 |
| LVEF (%) | 35.1±12.5 | 61.5±7.7 | <0.001 |
[i] SBP, Systolic blood pressure; DBP, Diastolic blood pressure; IVSD, end-diastolic interventricular septal diameter; LVEDD, left ventricular end-diastolic diameter; LVPWD, end-diastolic left ventricular posterior wall diameter; LVEF, left ventricular ejection fraction; SD, standard deviation.
Table 2.
Association of rs35006907 with DCM.
| SNP | Function | Population | MAF | Genotype | Model | P-Value | OR (95%CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| CC | CA | AA | Additive | 0.004 | 0.78 (0.66–0.93) | ||||
| rs35006907 | Enhancer | Control | 0.44 | 194 | 280 | 126 | Dominant | 0.16 | 0.84 (0.66–1.07) |
| C>A | DCM | 0.38 | 192 | 268 | 69 | Recessive | 0.0005 | 0.56 (0.41–0.78) | |
[i] Odds Ratios (ORs) and 95% confidence intervals (CIs) were obtained by logistic regression.
Figure 1.
Comparison of clinical characteristics including LVEDD (A), LVEF (B), IVSD (C) and LVPWD (D) among DCM with different genotypes.
Figure 2.
Functional analysis of rs35006907. A, B Expression difference of MTSS1 mRNA and protein among three genotypes using human heart samples; C Comparison of MTSS1 mRNA in lymphocytes; D Firefly luciferase assays using AC16 and 293T for activity comparison of rs35006907-C and A allele.