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Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for the differentially expressed RNAs (DERs)_
| Category | Term | Count | P-Value | Genes |
|---|---|---|---|---|
| Biology Process | GO:0006935~chemotaxis | 8 | 3.110E-04 | MAP2K1, CXCL9, AMOT, etc |
| GO:0006636~unsaturated fatty acid biosynthetic process | 4 | 4.770E-04 | FADS1, SCD, FADS2, etc | |
| GO:0007267~cell-cell signaling | 10 | 1.513E-03 | SH2D1A, ADM, FADS1, etc | |
| GO:0007568~aging | 8 | 1.848E-03 | TYMS, ADM, APOD, etc | |
| GO:0007166~cell surface receptor signaling pathway | 10 | 2.538E-03 | MARCO, PRLR, TSPAN3, etc | |
| GO:0055114~oxidation-reduction process | 15 | 4.070E-03 | KDM6A, HSD17B2, PYROXD2, etc | |
| GO:0016337~single organismal cell-cell adhesion | 6 | 4.312E-03 | MPZL2, PKHD1, FAT1, etc | |
| GO:0006629~lipid metabolic process | 7 | 6.425E-03 | APOD, PLIN1, APOF, etc | |
| GO:0070098~chemokine-mediated signaling pathway | 5 | 6.698E-03 | TFF2, CXCL9, ACKR3, etc | |
| GO:0032496~response to lipopolysaccharide | 7 | 7.895E-03 | ADM, DUSP10, CXCL9, etc | |
| GO:0010508~positive regulation of autophagy | 4 | 8.546E-03 | RNF152, FOXO1, TRIM22, etc | |
| GO:0035338~long-chain fatty-acyl-CoA biosynthetic process | 4 | 9.779E-03 | SCD, FASN, ELOVL6, ACSL5 | |
| GO:0006915~apoptotic process | 13 | 1.716E-02 | PEG10, RASSF6, LITAF, etc | |
| GO:0002250~adaptive immune response | 6 | 2.033E-02 | SH2D1A, EOMES, CD1C, etc | |
| GO:0006959~humoral immune response | 4 | 2.223E-02 | SH2D1A, BST1, LTF, CD28 | |
| GO:0006968~cellular defense response | 4 | 2.767E-02 | SH2D1A, CXCL9, LBP, etc | |
| GO:0060326~cell chemotaxis | 4 | 3.124E-02 | CXCL9, CCL5, DOCK4, etc | |
| GO:0045766~positive regulation of angiogenesis | 5 | 3.346E-02 | ADM, LRG1, RHOB, etc | |
| GO:0032868~response to insulin | 4 | 3.374E-02 | ADM, INSIG2, FADS1, PCK1 | |
| GO:0008203~cholesterol metabolic process | 4 | 3.504E-02 | INSIG2, APOF, LEPR, ERLIN1 | |
| GO:0001889~liver development | 4 | 4.331E-02 | COBL, ONECUT1, DBP, RPGRIP1L | |
| GO:0006954~inflammatory response | 9 | 4.788E-02 | LXN, AOX1, LYZ, etc | |
| KEGG Pathway | hsa01212:Fatty acid metabolism | 6 | 2.300E-04 | FADS1, SCD, FASN, etc |
| hsa03320:PPAR signaling pathway | 6 | 1.090E-03 | PLIN1, SCD, FADS2, etc | |
| hsa04620:Toll-like receptor signaling pathway | 7 | 1.479E-03 | CTSK, MAP2K1, CXCL9, etc | |
| hsa01040:Biosynthesis of unsaturated fatty acids | 4 | 2.350E-03 | FADS1, SCD, FADS2, ELOVL6 | |
| hsa04640:Hematopoietic cell lineage | 6 | 3.475E-03 | CR1, CD2, CD1C, etc | |
| hsa04152:AMPK signaling pathway | 6 | 1.465E-02 | LEPR, SCD, FASN, etc | |
| hsa04668:TNF signaling pathway | 5 | 3.695E-02 | MAP2K1, IL15, CREB3L3, etc | |
| hsa00760:Nicotinate and nicotinamide metabolism | 3 | 4.529E-02 | BST1, ENPP3, AOX1 | |
| hsa04060:Cytokine-cytokine receptor interaction | 7 | 4.659E-02 | PRLR, LEPR, CXCL9, etc |
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for the mRNA in the ceRNA regulatory network_
| Category | Term | Count | P-Value | Genes |
|---|---|---|---|---|
| Biology Process | GO:0008610~lipid biosynthetic process | 12 | 1.15E-06 | PRLR, ADM, ISPD, etc |
| GO:0008202~steroid metabolic process | 9 | 1.26E-05 | PRLR, INSIG2, ADM, etc | |
| GO:0006694~steroid biosynthetic process | 6 | 9.34E-05 | PRLR, ADM, FDPS, etc | |
| GO:0006633~fatty acid biosynthetic process | 5 | 8.64E-04 | FADS1, SCD, FASN, etc | |
| GO:0046649~lymphocyte activation | 6 | 4.38E-03 | PRLR, EOMES, IL15, etc | |
| GO:0016053~organic acid biosynthetic process | 5 | 9.79E-03 | FADS1, SCD, FASN, etc | |
| GO:0046394~carboxylic acid biosynthetic process | 5 | 9.79E-03 | FADS1, SCD, FASN, etc | |
| GO:0045321~leukocyte activation | 6 | 9.84E-03 | PRLR, EOMES, IL15, etc | |
| GO:0006355~regulation of transcription, DNA-dependent | 18 | 1.19E-02 | CAMTA2, MAP2K1, LITAF, etc | |
| GO:0030334~regulation of cell migration | 5 | 1.31E-02 | MAP2K1, CLIC4, AMOT, etc | |
| GO:0051252~regulation of RNA metabolic process | 18 | 1.47E-02 | CAMTA2, MAP2K1, etc | |
| GO:0007267~cell-cell signaling | 9 | 1.52E-02 | ADM, FADS1, FAT1, etc | |
| GO:0051094~positive regulation of developmental process | 6 | 1.71E-02 | MAP2K1, EOMES, AMOT, etc | |
| GO:0001775~cell activation | 6 | 1.93E-02 | PRLR, EOMES, IL15, etc | |
| GO:0040012~regulation of locomotion | 5 | 2.00E-02 | MAP2K1, CLIC4, AMOT, etc | |
| GO:0051270~regulation of cell motion | 5 | 2.04E-02 | MAP2K1, CLIC4, AMOT, etc | |
| GO:0009719~response to endogenous stimulus | 7 | 2.19E-02 | MAP2K1, ADM, FADS1, etc | |
| GO:0006631~fatty acid metabolic process | 5 | 2.21E-02 | FADS1, SCD, FASN, etc | |
| GO:0045860~positive regulation of protein kinase activity | 5 | 3.23E-02 | PRLR, MAP2K1, CD24, etc | |
| GO:0060429~epithelium development | 5 | 3.42E-02 | STX2, MAP2K1, RPGRIP1L, etc | |
| GO:0033674~positive regulation of kinase activity | 5 | 3.61E-02 | PRLR, MAP2K1, CD24, etc | |
| GO:0051347~positive regulation of transferase activity | 5 | 4.06E-02 | PRLR, MAP2K1, CD24, etc | |
| GO:0001568~blood vessel development | 5 | 4.33E-02 | LEPR, FOXO1, AMOT, etc | |
| GO:0051254~positive regulation of RNA metabolic process | 7 | 4.51E-02 | CAMTA2, MAP2K1, CSRNP1, etc | |
| GO:0001944~vasculature development | 5 | 4.66E-02 | LEPR, FOXO1, AMOT, etc | |
| GO:0009725~response to hormone stimulus | 6 | 4.80E-02 | MAP2K1, ADM, FADS1, etc | |
| GO:0030030~cell projection organization | 6 | 4.84E-02 | STX2, MAP2K1, ADM, etc | |
| GO:0007243~protein kinase cascade | 6 | 4.94E-02 | PRLR, MAP2K1, DUSP10, etc | |
| KEGG Pathway | hsa01040:Biosynthesis of unsaturated fatty acids | 4 | 2.39E-05 | FADS1, SCD, FADS2, ELOVL6 |
| hsa00900:Terpenoid backbone biosynthesis | 2 | 8.23E-03 | FDPS, MVK | |
| hsa00534:Heparan sulfate biosynthesis | 2 | 1.38E-02 | EXT1, HS3ST3B1 | |
| hsa04910:Insulin signaling pathway | 3 | 1.79E-02 | MAP2K1, FASN, FOXO1 | |
| hsa04060:Cytokine-cytokine receptor interaction | 4 | 1.86E-02 | PRLR, LEPR, IL15, CXCL10 | |
| hsa04010:MAPK signaling pathway | 4 | 1.93E-02 | MAP2K1, DUSP10, MAP3K13, FGF2 | |
| hsa04630:Jak-STAT signaling pathway | 3 | 2.21E-02 | PRLR, LEPR, IL15 | |
| hsa05200:Pathways in cancer | 4 | 2.87E-02 | MAP2K1, FZD1, FOXO1, FGF2 | |
| hsa03320:PPAR signaling pathway | 2 | 3.28E-02 | SCD, FADS2 |