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Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors Cover

Mutation status and immunohistochemical correlation of EGFR mutations in gastrointestinal stromal tumors

Open Access
|Jul 2021

Figures & Tables

Figure 1

Images a-d show immunohistochemical staining of GIST samples with spindle-shaped tumor cells, negative for EGFR expression. Images e-f indicate hematoxylin and eosin staining of GIST samples with spindle-shaped tumor cells. Image g represents the positive control, expressing EGFR. All images were taken in 40× magnification. Image h represents the control EGFR sample from a chorionic villus sample.
Images a-d show immunohistochemical staining of GIST samples with spindle-shaped tumor cells, negative for EGFR expression. Images e-f indicate hematoxylin and eosin staining of GIST samples with spindle-shaped tumor cells. Image g represents the positive control, expressing EGFR. All images were taken in 40× magnification. Image h represents the control EGFR sample from a chorionic villus sample.

Patient details such as age, gender, tumor locations, cell types and EGFR gene mutation status are shown_

SexMean AgeTumor Location (%)Tumor Cell Type (%)Status of Analyzed EGFR Gene Mutations Exons (codons)EGFR Expression
18 (719)19 (deletion)20 (768; 790)21 (858; 861)
F57.2±5.6duodenum (21.5)spindle cell (100.0)wild typewild typewild typewild typenegative
ileum (10.5)epithelioid (100.0)wild typewild typewild typewild typenegative
small intestine (26.3);epithelioid (20.0);mixed (60.0);spindle cell (20.0)wild typewild typewild typewild typenegative
stomach (38.8)spindle cell (57.0);mixed (14.2);epithelioid (28.8)wild typewild typewild typewild typenegative
transverse colon (5.2)mixed (100.0)wild typewild typewild typewild typenegative
M62.6±10.5colon (9.5)spindle cell (100.0)wild typewild typewild typewild typenegative
descending colon (4.7)mixed (100.0)wild typewild typewild typewild typenegative
duodenum (4.7)spindle cell (100.0)wild typewild typewild typewild typenegative
ileum (4.7)mixed (100.0)wild typewild typewild typewild typenegative
jejenum (4.7)spindle cell (100.0)wild typewild typewild typewild typenegative
small intestine (19.0)spindle cell (25.0);mixed (75.0)wild typewild typewild typewild typenegative
Stomach (52.4)spindle cell (54.5);mixed (36.3);epithelioid (9.2)wild typewild typewild typewild typenegative
Language: English
Page range: 67 - 72
Published on: Jul 27, 2021
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2021 H Ozkayalar, MC Ergoren, G Tuncel, S Kurt, E Cevik, S Ozemri Sag, B Yilmaz Ozguven, F Kabukcuoglu, G Mocan, ŞG Temel, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.