Single nucleotide polymorphism information and Hardy-Weinberg p values in the study population_
| SNP | Gene/ Closest Gene | Chromosomal Position | Location | Allele Change | Amino Acid Change | HWE p Value |
|---|---|---|---|---|---|---|
| rs10783050 | EEF1A1P11-RPL7P9 | 1:96571527 | intergenic | T>C | – | 0.932 |
| rs1143623 | IL1B | 2:112838252 | intergenic | C>G | – | 0.309 |
| rs13266634 | SLC30A8 | 8:117172544 | missense | C>A/T | Arg325Trp | 0.532 |
| rs13376631 | FMO1 | 1:171266603 | intron | A>G | – | 0.903 |
| rs1801282 | PPARG | 3:12351626 | missense | C>G | Pro12Ala | monomorphic |
| rs249429 | PRKAA1 | 5:40782137 | intron | C>T | – | 0.299 |
| rs2815752 | NEGR1 | 1:72346757 | intergenic | G>A | – | 0.636 |
| rs316009 | SLC22A2 | 6:160254732 | intron | C>T/G | – | 0.595 |
| rs316019 | SLC22A2 | 6:160249250 | missense | C>A | Ala270Ser | 0.808 |
| rs391300 | SRR | 17:2312964 | intron | C>T | – | 0.739 |
| rs461473 | SLC22A1 | 6:160122530 | intron | G>A | – | 0.898 |
| rs4810083 | PCK1 | 20:57545215 | intergenic | C>T | – | 0.145 |
| rs578427 | – | 6:91702432 | intergenic | T>C | – | 0.909 |
| rs622342 | SLC22A1 | 6:160151834 | intron | A>C | – | 0.218 |
| rs6265 | BDNF; BDNF-AS | 11:27658369 | missense | C>T | Val66Met | monomorphic |
| rs819 2675 | SLC2A2 | 3:171007094 | intron | C>T | – | 0.674 |
Genotype and allele frequencies of 13 single nucleotide polymorphism(s) demonstrating no significant association to type 2 diabetes mellitus treatment response_
| SNP | Genotype/ Allele | Control n (%) | Uncontrolled n (%) | OR (95% CI) | p Values |
|---|---|---|---|---|---|
| rs10783050 | TT | 52 (98.1) | 86 (98.9) | reference | |
| TC | 1 (1.9) | 0 (0.0) | 0.20 (0.01-5.06) | 0.331 | |
| T | 105 (99.1) | 172 (98.9) | reference | ||
| C | 1 (0.9) | 0 (0.0) | 0.20 (0.01-5.05) | 0.332 | |
| rs1143623 | CC | 48 (90.6) | 74 (85.1) | reference | |
| CG | 5 (9.4) | 11 (12.6) | 1.43 (0.47-4.36) | 0.533 | |
| C | 96 (90.6) | 159 (91.4) | reference | ||
| G | 10 (9.4) | 11 (6.3) | 0.66 (0.27-1.62) | 0.369 | |
| rs13266634 | CC | 50 (94.3) | 78 (89.7) | reference | |
| CT | 3 (5.7) | 8 (9.2) | 1.71 (0.43-6.75) | 0.444 | |
| 100 (94.3) | 164 (94.3) | reference | |||
| 6 (5.7) | 8 (4.6) | 0.81 (0.27-2.41) | 0.709 | ||
| rs13376631 | AA | 16 (30.2) | 22 (25.3) | reference | |
| GG | 11 (20.8) | 17 (19.5) | 1.12 (0.42-3.04) | 0.818 | |
| AG | 25 (13.3) | 37 (42.5) | 1.08 (0.47-2.44) | 0.860 | |
| 57 (53.8) | 81 (46.6) | reference | |||
| 47 (44.3) | 71 (40.8) | 1.06 (0.64-1.75) | 0.811 | ||
| rs1801282 | CC | 53 (100.0) | 86 (98.9) | monomorphic | monomorphic |
| C | 106 (100.0) | 172 (98.9) | – | ||
| rs249429 | TT | 28 (52.8) | 40 (46.0) | reference | |
| CC | 3 (5.7) | 6 (6.9) | 1.40 (0.32-6.07) | 0.650 | |
| CT | 22 (41.5) | 40 (46.0) | 1.27 (0.6258-2.5885) | 0.510 | |
| T | 78 (73.6) | 120 (69.0) | reference | ||
| C | 28 (26.4) | 52 (29.9) | 1.21 (0.70-2.07) | 0.500 | |
| rs2815752 | GG | 18 34.0) | 22 (25.3) | reference | |
| AA | 13 (24.5) | 20 (23.0) | 1.26 (0.49-3.21) | 0.630 | |
| GA | 22 (41.5) | 43 (49.4) | 1.60 (0.71-3.59) | 0.254 | |
| 58 (54.7) | 87 (50.0) | reference | |||
| 48 (45.2) | 83 (47.7) | 1.15 (0.71-3.59) | 0.567 | ||
| rs34834489 | GG | 46 (86.7) | 80 (92.0) | reference | |
| GA | 6 (11.3) | 6 (6.9) | 0.58 (0.18-1.89) | 0.361 | |
| 98 (92.5) | 166 (95.4) | reference | |||
| 6 (5.7) | 6 (3.4) | 0.59 (0.19-1.88) | 0.373 | ||
| rs391300 | CC | 9 (17.0) | 17 (19.5) | reference | |
| TT | 18 (34.0) | 24 (27.6) | 0.71 (0.26-1.94) | 0.500 | |
| CT | 26 (49.1) | 44 (50.6) | 0.90 (0.35-02.30) | 0.819 | |
| 44 (41.5) | 78 (44.8) | reference | |||
| 62 (58.5) | 92 (52.9) | 0.84 (0.51-1.37) | 0.477 | ||
| rs461473 | GG | 52 (98.1) | 84 (96.6) | reference | |
| GA | 1 (1.9) | 2 (2.3) | 1.24 (0.11-14.00) | 0.863 | |
| 105 (99.1) | 170 (97.7) | reference | |||
| 1 (0.9) | 2 (1.1) | 1.24 (0.11-13.99) | 0.864 | ||
| rs622342 | AA | 33 (62.3) | 48 (55.2) | reference | |
| CC | 3 (5.7) | 12 (13.8) | 4.13 (0.87-19.65) | 0.075 | |
| CA | 18 (34.0) | 26 (29.9) | 0.99 (0.472.10) | 0.985 | |
| 84 (79.2) | 122 (70.1) | reference | |||
| 22 (20.8) | 50 (28.7) | 1.56 (0.88-2.78) | 0.113 | ||
| rs6265 | CC | 53 (100.0) | 86 (98.9) | monomorphic | monomorphic |
| C | 106 (100.0) | 172 (98.9) | – | – | |
| rs8192675 | CC | 42 (79.2) | 58 (66.7) | reference | |
| TT | 1 (1.9) | 3 (3.4) | 2.17 (0.22-21.62) | 0.508 | |
| CT | 9 (17.0) | 25 (28.7) | 2.01 (0.85-4.75) | 0.111 | |
| 93 (87.7) | 141 (81.0) | reference | |||
| 11 (10.4) | 31 (17.8 | 1.86 (0.89-3.88) | 0.099 |
Genotype and allele frequencies of four single nucleotide polymorphism(s) demonstrating no significant association to type 2 diabetes mellitus treatment response_
| Unadjusted | Adjusted | |||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Genotype/ Allele | Controlled n (%) | Uncontrolled n (%) | OR (95% CI) | p Values | OR (95% CI) | p Values | Bonferonni Corrected p Values |
| rs316009 | CC | 45 (84.9) | 83 (95.4) | reference | reference | |||
| CT | 8 (15.1) | 3 (0.03) | 0.20 (0.05-0.81) | 0.023 | 0.31 (0.05-0.190) | 0.204 | – | |
| 98 (92.5) | 169 (97.1) | reference | reference | |||||
| 8 (0.08) | 3 (0.02) | 0.22 (0.06-0.84) | 0.027 | 0.85 (0.01-0.93) | 0.044 | 0.088 | ||
| rs316019 | CC | 41 (77.4) | 77 (88.5) | reference | reference | |||
| AA | 1 (0.02) | 0 (0.0) | 0.18 (0.01-4.48) | 0.295 | ||||
| CA | 11 (20.8) | 8 (0.09) | 0.39 (0.14-1.04) | 0.059 | ||||
| C | 93 (87.7) | 162 (93.1) | reference | reference | ||||
| A | 13 (12.3) | 8 (0.05) | 0.35 (0.14-0.8) | 0.026 | 0.72 (0.21-2.44) | 0.593 | – | |
| rs4810083 | CC | 16 (30.2) | 33 (37.9) | reference | reference | |||
| TT | 10 (18.9) | 32 (36.9) | 1.55 (0.61-3.92) | 0.353 | 1.24 (0.42-3.60) | 0.698 | – | |
| CT | 27 (35.7) | 21 (43.1) | 0.38 (0.17-0.86) | 0.021 | 2.80 (1.01-7.79) | 0.049 | 0.098 | |
| 59 (55.7) | 75 (43.1) | reference | reference | |||||
| 47 (44.3) | 97 (55.7) | 1.62 (1.00-2.64) | 0.051 | 0.81 (0.48-1.36) | 0.423 | – | ||
| rs578427 | TT | 10 (18.9) | 15 (17.2) | reference | reference | |||
| CC | 4 (7.5) | 28 (32.2) | 4.67 (1.25-17.44) | 0.022 | 1.80 (0.58-5.64) | 0.312 | ||
| CT | 39 (73.6) | 43 (49.4) | 0.74 (0.30-1.83) | 0.507 | 1.70 (0.45-2.55) | 0.884 | ||
| T | 47 (44.3) | 73 (42.0) | reference | reference | ||||
| C | 59 (55.7) | 99 (56.9) | 1.08 (0.66-1.76) | 0.765 | 1.31 (0.78-2.22) | 0.308 | – | |
Clinical and biochemical demographics of the study population_
| Parameters | Controlled (n = 53) | Uncontrolled (n = 87) | p Value |
|---|---|---|---|
| Sex (F; M) | F: 36; M: 14 | F: 57; M: 30 | – |
| Age (years) | 60.7 ± 11.0 | 58.3 ± 11.4 | 0.470 |
| Weight (kg) | 85.8 ± 19.5 | 85.4 ± 19.1 | 0.833 |
| Height (cm) | 162.1 ± 7.8 | 163.1 ± 7.7 | 0.487 |
| Body mass index | 31.9 ± 8.4 | 30.4 ± 10.7 | 0.304 |
| Hb A1c (%): | |||
| baseline | 7.6 ± 2.0 | 11.0 ± 2.9 | <0.001 |
| 12 months | 6.7 ± 1.2 | 11.5 ± 2.9 | <0.001 |
| Random blood sugar (%) | 9.4 ± 3.9 | 14.5 ± 6.6 | <0.001 |
| Systolic blood pressure (mmHg) | 147.0 ± 24.0 | 153.5 ± 23.9 | 0.130 |
| Diastolic blood pressure (mmHg) | 83.9 ± 15.5 | 90.3 ± 13.7 | 0.018 |
| Total cholesterol (mmol/L) | 4.4 ± 1.1 | 5.0 ± 1.1 | 0.001 |
| High-density lipoprotein (mmol/L) | 1.2 ± 0.4 | 1.2 ± 0.4 | 0.672 |
| Low-density lipoprotein (mmol/L) | 2.3 ± 0.9 | 2.8 ± 0.9 | 0.007 |
| Triglycerides (mmol/L) | 2.0 ± 1.2 | 2.3 ± 1.1 | 0.215 |
| Creatinine (g/mol) | 157.7 ± 383.1 | 79.3 ± 29.5 | 0.317 |
| Glomerular filtration rate (mL/min/1.73 m2 | 41.7 ± 21.5 | 52.6 ± 25.0 | 0.313 |