GA genotype of the Arg280His polymorphism on the XRCC1 gene: Genetic susceptibility genotype in differentiated thyroid carcinomas?

Characteristics	DTC Cases n=228 (%)	BTN Cases n=100 (%)	Controls n=93 (%)	p Value^a	p Value^b
Age (years)	45.44±12.89	46.64±13.28	45.06±11.25	0.647	0.960
Gender:				0.025	0.051
females	176 (77.2)	83 (83.0)	62 (66.7)
males	52 (22.8)	17 (17.0)	31 (33.3)
Body mass index:				<0.001	0.056
<25	130 (57.0)	43 (43.0)	65 (69.9)
≤25-<30	47 (20.6)	16 (16.0)	17 (18.3)
≥30	51 (22.4)	41 (41.0)	11 (11.8)
Family history of thyroid cancer:				0.001	0.005
yes	18 (7.9)	1 (1.0)	0 (0.0)
no	210 (92.1)	99 (99.0)	93 (100.0)
Histological type:
papillary carcinoma	221 (96.9)
follicular carcinoma	7 (3.1)
Hashimoto’s thyroiditis:				0.013	0.690
yes	28 (12.3)	25 (25.0)	13 (14.0)
no	199 (87.7)	75 (75.0)	80 (86.0)
Smoking status:				0.201	0.817
yes	44 (19.3)	28 (28.0)	19 (20.4)
no	184 (80.7)	72 (72.0)	74 (78.4)
Thyroid stimulating hormone level:				<0.001	0.063
<0.35	7 (3.1)	8 (8.0)	0 (0.0)
0.35-4.50	215 (94.3)	66 (66.0)	93 (100.0)
>4.50	6 (2.6)	26 (26.0)	0 (0.0)

[i] DTC: differentiated thyroid carcinomas; BTN: benign thyroid nodule

^a The comparison of DTC vs. BTN vs. controls.

^b The comparison of DTC vs. controls.

Genotype frequencies for each of the selected XRCC1 polymorphisms in differentiated thyroid carcinoma, benign thyroid nodule and control groups.

Polymorphisms	DTC Cases n=228 (%)	BTN Cases n=100 (%)	Controls n=93 (%)	p Value
Genotype Frequency: Arg280His GG	5 (2.6)^a	1 (1.0)	0 (0.0)	0.04^a
GA	141 (61.8)^b	34 (34.0)^b	3 (3.2)	<0.0001^b
AA	81 (35.5)^c	65 (65.0)	90 (96.8)^c	<0.001^a
Allele frequency:
A	305 (67.0)	162 (81.0)	183 (98.0)
G	151 (33.0)	38 (19.0)	3 (2.0)
Genotype frequency: Arg194Trp
CC	223 (97.8)	97 (97.0)	83 (89.2)	0.001^a
CT	5 (2.2)^a	3 (3.0)^a	10 (10.8)	0.032^c
Allele frequency:
C	451 (99.0)	197 (98.0)	176 (95.0)
T	5 (1.0)	3 (2.0)	10 (5.0)
Genotype frequency: Arg399Gln
GG	106 (46.5)	52 (52.0)	33 (35.5)
GA	100 (43.9)	33 (33.0)	48 (51.6)
AA	22 (9.6)	15 (15.0)	12 (12.9)
Allele frequency:
G	311 (68.0)	138 (69.0)	114 (61.0)
A	145 (32.0)	62 (31.0)	72 (39.0)

[i] DTC: diferentiated thyroid carcinoma; BTN: benign thyroid nodules.

^a Diferentiated thyroid carcinoma and controls.

^b Diferentiated thyroid carcinoma and controls; BTN and controls.

^c Benign thyroid nodules and controls.

Genotype frequencies in patients with a family history of thyroid cancer.

Polymorphisms	DTC Cases n=228 (%)	BTN Cases n=100	Total n=328 (%)	p Value
Arg280His:				0.004
GG	0 (0.0)	0 (0.0)	0 (0.0)
GA	15 (83.3)	0 (0.0)	15 (78.9)
AA	3 (16.7)	1 (100.0)	4 (21.1)
Arg194Trp:				0.346
CC	18 (100.0)	1 (100.0)	19 (100.0)
CT	0 (0.0)	0 (0.0)	0 (0.0)
Aarg399Gln:				0.704
GG	7 (38.9)	0 (0.0)	7 (36.8)
GA	9 (50.0)	0 (0.0)	9 (47.4)
AA	2 (11.1)	1 (100.0)	3 (15.8)

[i] DTC: diferentiated thyroid canrcinoma; BTN: benign thyroid nodule.

DOI: https://doi.org/10.2478/bjmg-2021-0003 | Journal eISSN: 2199-5761 (formerly 1311-0160) | Journal ISSN: 1311-0160

Language: English

Page range: 73 - 80

Published on: Jul 27, 2021

Published by: Macedonian Academy of Sciences and Arts

In partnership with: Paradigm Publishing Services

Keywords:

Related subjects:

© 2021 NG Kirnap, NB Tutuncu, Y Yalcin, HPB Cebi, T Tutuncu, A Nar, H Verdi, FB Atac, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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