Figure 1
Figure 2
Figure 3
Correlation of polymorphisms in the CYP2B6, GABRA1 and ABCB1 genes and doses of propofol used for the introduction and additional doses during anesthesia_
| Genes | CYP2B6 (c.516G>T) | GABRA1 (c.1059+15G>A) | ABCB1 (c.3435T>C) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alleles (n) | GG (53) | GA (32) | AA (5) | p Value | GG (34) | AG (38) | AA (18) | p Value | TT (23) | CC (22) | CT (45) | p Value |
| Introduction to anesthesia: Propofol (mg) | ||||||||||||
| Mean±SD | 144.7± 40.9 | 141.0± 39.9 | 133.9± 40.7 | 0.80 | 140.6± 40.2 | 138.9± 42.0 | 143.2± 37.1 | 0.45 | 132.0± 47.0 | 152.2± 38.2 | 146.7± 42.5 | 0.56 |
| Additional dose: Propofol (mg) | ||||||||||||
| Mean±SD | 129.3± 43.6 | 145.0± 52.3 | 126.7± 47.5 | 0.46 | 146.7± 51.6 | 122.4± 40.3 | 130.0± 48.3 | 0.41 | 12.3± 68.1 | 144.4± 52.7 | 140.4± 48.3 | 0.57 |
The most common side effects of Propofol in correlation with different genotypes_
| Genes | CYP2B6 (c.516G>T) | GABRA1 (c.1059+15G>A) | ABCB1 (c.3435T>C) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alleles (n) | GG (53) | GT (32) | TT (5) | p Value | GG (34) | AG (38) | AA (18) | p Value | TT (23) | CC (22) | CT (45) | p Value |
| Nausea | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||
| score 0 | 51 (96.22) | 30 (93.74) | 5 (100.0) | 0.74 | 32 (94.12) | 36 (94.74) | 18 (100.0) | 0.54 | 23 (100.0) | 21 (95.45) | 42 (93.33) | 0.52 |
| score 1 | 1 (1.89) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.63) | 0 (0.0) | 0 (0.0) | 1 (4.55) | 0 (0.0) | |||
| score 2 | 1 (1.89) | 1 (3.13) | 0 (0.0) | 2 (5.88) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (4.44) | |||
| score 3 | 0 (0.0) | 1 (3.13) | 0 (0.0) | 0 (0.0) | 1 (2.63) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.22) | |||
| Vomiting | ||||||||||||
| #0 | 52 (98.11) | 30 (93.74) | 5 (100.0) | 0.55 | 32 (94.12) | 37 (97.37) | 18 (100.0) | 0.33 | 23 (100.0) | 22 (100.0) | 42 (93.33) | 0.75 |
| #1 | 1 (1.89) | 1 (3.13) | 0 (0.0) | 2 (5.88) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (4.44) | |||
| #2 | 0 (0.0) | 1 (3.13) | 0 (0.0) | 0 (0.0) | 1 (2.63) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.22) | |||
| Sedation | ||||||||||||
| score 0 | 46 (86.79) | 32 (100.0) | 5 (100.0) | 0.69 | 31 (91.18) | 34 (89.47) | 18 (100.0) | 0.96 | 21 (91.30) | 21 (95.45) | 41 (91.11) | 0.88 |
| score 1 | 1 (1.89) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.63) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.22) | |||
| score 2 | 3 (5.66) | 0 (0.0) | 0 (0.0) | 2 (5.88) | 1 (2.63) | 0 (0.0) | 1 (4.35 | 0 (0.0) | 2 (4.44) | |||
| score 3 | 2 (3.77) | 0 (0.0) | 0 (0.0) | 1 (2.94) | 1 (2.63) | 0 (0.0) | 1 (4.35) | 1 (4.55) | 0 (0.0) | |||
| score4 | 1 (1.89) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.63) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (2.22) | |||
Distribution of the polymorphisms of the examined genes in patients_
| CYP2B6(c.516G>T) | GABRA1(c.1059+15G>A) | ABCB1(c.3435T>C) | ||||||
|---|---|---|---|---|---|---|---|---|
| GG | GT | TT | GG | AG | AA | CC | CT | TT |
| 0.59 | 0.36 | 0.05 | 0.38 | 0.42 | 0.20 | 0.24 | 0.50 | 0.26 |