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An investigation of the COMT gene Val158Met polymorphism in patients admitted to the emergency department because of synthetic cannabinoid use Cover

An investigation of the COMT gene Val158Met polymorphism in patients admitted to the emergency department because of synthetic cannabinoid use

Open Access
|Aug 2020

Figures & Tables

Figure 1

Sequence analysis image of the codon 158 region of the COMT gene. a) WT; b) homozygote p.Val158Met exchange; c) heterozygote p.Val158Met exchange.

Table 1

Demographic and genotypic distribution of patient and control groups.

Patients (n=49)Controls (n=50)
GenderMales48 (98.0%)48 (96.0%)
Females1 (2.0%)2 (4.0%)
Age26.7±6.932.4±7.2
GenotypeWild-type1420
Heterozygotes2522
Homozygotes108

[i] Heterozygotes: p.Val158Med exchange;

Homozygotes: p.Val158Met exchange.

Table 2

Genotypic characteristics of patients with and without hospitalization at the Bursa Treatment and Research Center for Alcohol and Drug Addiction, Bursa, Turkey.

Genotypic Characteristics Total (n)Total (n)
Wild-TypeHomozygotes
Hospitalizationyesn(%)33 (82.2)4 (10.8)37 (100.0)
non(%)6 (50.0)6 (50.0)12 (100.0)
Total (n)n(%)39 (79.6)10 (20.4%)49 (100.0)

[i] Homozygotes: p.Val158Met exchange.

DOI: https://doi.org/10.2478/bjmg-2020-0010 | Journal eISSN: 2199-5761 (formerly 1311-0160) | Journal ISSN: 1311-0160
Language: English
Page range: 63 - 68
Published on: Aug 26, 2020
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services

© 2020 Y Nennicioglu, H Kaya, S Eraybar, S Atmaca, O Gorukmez, E Armagan, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.