Skip to main content
Have a personal or library account? Click to login
Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents Cover

Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

Open Access
|Aug 2020

Figures & Tables

Table 1

Mean values and range of analyzed parameters depending on gender.

ParametersTotal (n = 308) (range)Boys (n = 153)Girls (n = 155)p Value
BMI (kg/m2)22.03±4.25 (13.8-43.72)21.77±4.2222.29±4.290.405
FBG (mmol/L)4.68±0.63 (2.43-6.30)4.75±0.594.61±0.660.660
TG (mmol/L)0.98±0.55 (0.32-2.54)0.97±0.620.99±0.470.891
TC (mmol/L)4.35±0.86 (2.64-6.70)4.18±0.764.51±0.930.001
HDL-C (mmol/L)1.41±0.40 (0.28-2.63)1.37±0.421.45±0.380.159
LDL-C (mmol/L)2.47±0.86 (0.53-4.82)2.39±0.812.55±0.900.057

[i] BMI: body mass index; FBG: fasting blood glucose; TG: triglycerides; TC: statistically significant total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol.

Table 2

Frequencies of BDNF genotypes and alleles.

BDNF rs6265
Genotypes
Frequency
n (%)
AllelesFrequencies
(%)
GG202 (65.6)G0.82
GA103 (33.4)
AA3 (1-0)A0.18

[i] BDNF: brain-derived neurotrophic factor.

Table 3

Mean values of analyzed parameters by BDNF rs6265 genotype (mean±SD).

ParametersGenotypeTotalp ValueBoysp ValueGirlsp Value
BMI (kg/m2)GG
GA+AA
22.17±4.37
21.76±3.82
0.37821.79±4.14
21.74±4.40
0.71522.54±4.57
21.80±3.67
0.367
FBG (mmol/L)GG
GA+AA
4.74±0.66
4.56±0.56
0.0104.79±0.62
4.68±0.55
0.3024.70±0.70
4.43±0.55
0.023
TG (mmol/L)GG
GA+AA
0.99±0.52
0.97±0.59
0.5990.96±0.54
0.99±0.75
0.6791.02±0.52
0.95±0.36
0.624
TC (mmol/L)GG
GA+AA
4.36±0.86
4.34±0.88
0.9314.18±0.74
4.20±0.82
0.8484.53±0.93
4.48±0.94
0.756
HDL-C (mmol/L)GG
GA+AA
1.42±0.42
1.44±0.44
0.4841.34±0.34
1.42±0.53
0.5801.45±0.41
1.48±0.33
0.659
LDL-C (mmol/L)GG
GA+AA
2.47±0.87
2.48±0.84
0.9112.38±0.85
2.40±0.80
0.8792.55±0.93
2.57±0.84
0.873

[i] BDNF: brain-derived neurotrophic factor; BMI: body mass index; FBG: Statistically significant fasting blood glucose; TG: triglycerides; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol.

DOI: https://doi.org/10.2478/bjmg-2020-0004 | Journal eISSN: 2199-5761 (formerly 1311-0160) | Journal ISSN: 1311-0160
Language: English
Page range: 77 - 82
Published on: Aug 26, 2020
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services

© 2020 V Vidović, N Maksimović, I Novaković, T Damnjanović, B Jekić, S Vidović, N Majkić Singh, M Stamenković-Radak, D Nikolić, D Marisavljević, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.