Table 1
Clinopathological characteristics, TWIST gene expression results and ATP-TCA results of samples.
| Sample | Tumor Grade | ER | PR | HER2 | Diagnosis | TWIST 1 Gene Expression Fold-Change | ATP-TCA Results |
|---|---|---|---|---|---|---|---|
| S1 | 3 | [+] | [+] | [–] | IDC | 4.25 | NR |
| S2 | 2 | [+] | [+] | [–] | IDC | 7.85 | NR |
| S3 | 3 | [+] | [+] | [–] | IDC | 6.70 | NR |
| S5 | 3 | [+] | [–] | [–] | IDC | 4.26 | R |
| S6 | 3 | [+] | [+] | [+] | IDC | 5.80 | R |
| S7 | 3 | [+] | [+] | [–] | IDC; multifocal | 5.36 | R |
| S9 | 3 | [+] | [+] | [–] | IDC | 4.74 | R |
| S10 | 3 | [+] | [+] | [+] | IDC | 3.67 | R |
| S11 | 3 | [+] | [+] | [+] | IDC | 6.06 | R |
| S12 | 3 | [+] | [–] | [+] | IDC | 4.44 | R |
| S13 | 3 | [+] | [+] | [+] | mixed IDC and IDC-L | 5.84 | NR |
| S14 | 3 | [+] | [+] | [+] | IDC; multifocal | 4.51 | R |
| S15 | 2 | [+] | [+] | [–] | mixed IDC and IDC-L | 3.87 | R |
| S17 | 3 | [+] | [+] | [–] | IDC | 4.88 | R |
| S18 | 3 | [–] | [–] | [–] | IDC | 5.56 | R |
| S19 | 2 | [+] | [+] | [–] | IDC | 5.56 | R |
| S21 | 2 | [+] | [+] | [+] | mixed IDC and IDC-L; multifocal | 5.28 | NR |
| S22 | 2 | [+] | [+] | [–] | IDC | 4.18 | R |
| S23 | 3 | [–] | [–] | [–] | IDC | 5.36 | NR |
| S27 | 3 | [+] | [+] | [–] | IDC | 2.62 | R |
| S29 | NA | NA | NA | NA | IDC | 4.43 | NR |
| S34 | 1 | [+] | [+] | [–] | invasive mucinous carcinoma of breast | 7.32 | NR |
| S54 | 3 | [+] | [+] | [+] | IDC | 3.97 | NR |
| S55 | 3 | [–] | [–] | [–] | IDC | 2.61 | R |
| S87 | 3 | [–] | [–] | [–] | IDC | 0.00 | R |
| S88 | 3 | [–] | [–] | [+] | IDC | 3.82 | R |
[i] ER: estrogene receptor; PR: progesterone receptor; HER2: ErbB2 receptor defined by immunohistochemistry; ATP-TCA: adenosine triphosphate tumor chemo-sensitivity assay; IDC: invasive ductal carcinoma; IDC-L: IDC with lobular features; NR: non responsive; R: responsive; NA not available.
Figure 1
The 2–ΔΔCT differences of resistant and responsive tumor groups (p=0,041).