Table 1
Clinicopathological features of the 551 patients.
| Clinicopathological Features | Total Patients (n) | Patients with Mutations or Wild-Type (n) | p Value | |
|---|---|---|---|---|
| Mutations | Wild-Type | |||
| Gender: | ||||
| males | 407 | 16 | 391 | <0.0001 |
| females | 144 | 39 | 105 | |
| Histology: | ||||
| adenocarcinomas | 276 | 41 | 235 | |
| other types | 275 | 14 | 261 | 0.000232 |
| Smoking history: | ||||
| smokers | 338 | 23 | 315 | |
| non smokers | 213 | 32 | 181 | 0.002807 |
Table 2
Types of the mutations detected.
| Mutations Detected | Patients (n) | % |
|---|---|---|
| Deletions in exon 19 | 31 | 56.4 |
| L858R | 20 | 36.4 |
| Insertions in exon 20 | 2 | 3.6 |
| Deletions in exon 19 and T790M | 1 | 1.8 |
| Deletions in exon 19 and S768I | 1 | 1.8 |
Figure 1
Plot shows EGFR positive samples for the exon 19 deletion; amplification of the internal control (Ctrl assay) with CT 26.45 and amplification for mutational assay (del assay) with CT 29.42. ΔCT = 2.97 (calculated by the formula ΔCT = mutation CT-control CT). The ΔCT cutoff value for this mutational assay was 9.06.