Genotype and allele distributions of the PCLO rs2522833, COMT rs4680 and SLC6A4 5-HTTLPR polymorphic variants in major depressive disorder/generalized anxiety disorder patients and controls_
| MDD/GAD Patients (n = 133) | Controls (n = 279) | p Value | |
|---|---|---|---|
| PCLO rs2522833 | |||
| Genotype frequencies: | n (%) | n (%) | |
| AA | 59 (0.44) | 122 (0.44) | |
| AC | 58 (0.43) | 112 (0.40) | 0.567 |
| CC | 16 (0.12) | 44 (0.16) | |
| Alleles: | |||
| A | 176 (0.66) | 356 (0.64) | 0.549 |
| C | 90 (0.34) | 176 (0.36) | |
| COMT rs4680 | |||
| Genotype frequencies: | n (%) | n (%) | |
| GG | 26 (0.21) | 67 (0.24) | |
| GA | 73 (0.56) | 154 (0.56) | 0.51 |
| AA | 31 (0.23) | 55 (0.20) | |
| Alleles: | |||
| G | 125 (0.48) | 288 (0.52) | |
| A | 135 (0.52) | 264 (0.48) | 0.276 |
| SLC6A4 50HTTLPR | |||
| Genotype frequencies: | n (%) | n (%) | |
| LL | 44 (0.34) | 100 (0.36) | |
| LS | 70 (0.52) | 131 (0.48) | 0.614 |
| SS | 19 (0.14) | 45 (0.16) | |
| Alleles: | |||
| L | 158 (0.59) | 331 (0.60) | |
| S | 108 (0.41) | 221 (0.40) | 0.877 |
Genotype and allele distribution of the PCLO rs2522833, COMT rs4680 and SLC6A4 5-HTTLPR polymorphic variants in major depressive disorder/generalized anxiety disorder patients with a positive or negative family history for depressive disorders_
| Positive Family History (n = 40) | p Value: Positive Family History vs. Controls | Negative Family History (n = 93) | p Value: Negative Family History vs. Controls | p Value: Positive vs. Negative Family History | |
|---|---|---|---|---|---|
| PCLO rs2522833 | |||||
| Genotype frequencies: | n (%) | n (%) | |||
| AA | 26 (0.65) | 33 (0.36) | |||
| AC | 14 (0.35) | 0.007 | 44 (0.47) | 0.354 | 0.001 |
| CC | 0 (0.00) | 16 (0.17) | |||
| Alleles: | |||||
| A | 66 (0.82) | 110 (0.59) | |||
| C | 14 (0.18) | 0.001 | 76 (0.41) | 0.232 | 0.000 |
| COMT rs4680 | |||||
| Genotype frequencies: | n (%) | n (%) | |||
| GG | 10 (0.25) | 16 (0.18) | |||
| GA | 18 (0.45) | 0.297 | 55 (0.61) | 0.439 | 0.232 |
| AA | 12 (0.30) | 19 (0.21) | |||
| Alleles: | |||||
| G | 38 (0.48) | 87 (0.48) | |||
| A | 42 (0.52) | 0.434 | 93 (0.52) | 0.371 | 0.901 |
| SLC6A4 50HTTLPR | |||||
| Genotype frequencies: | n (%) | n (%) | |||
| LL | 18 (0.45) | 26 (0.28) | |||
| LS | 18 (0.45) | 0.436 | 52 (0.56) | 0.302 | 0.148 |
| SS | 4 (0.10) | 15 (0.16) | |||
| Alleles: | |||||
| L | 54 (0.67) | 104 (0.56) | |||
| S | 26 (0.33) | 0.197 | 82 (0.44) | 0.332 | 0.078 |