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Genome-Wide Methylation Profiling of Schizophrenia Cover

Genome-Wide Methylation Profiling of Schizophrenia

Open Access
|Apr 2015

References

  1. 1. Tsuang MT, Faraone SV, Glatt SJ. Schizophrenia, 3rd ed. New York, NY: Oxford University Press, 2011.
  2. 2. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a metaanalysis of twin studies. Arch Gen Psychiatry. 2003; 60(12): 1187-1192.10.1001/archpsyc.60.12.1187
  3. 3. Stilo SA, Murray RM. The epidemiology of schizophrenia: replacing dogma with knowledge. Dialogues Clin Neurosci. 2010; 12(3): 305-315.10.31887/DCNS.2010.12.3/sstilo
  4. 4. van Os J, Kapur S. Schizophrenia. Lancet. 2009; 374(9690): 635-645.10.1016/S0140-6736(09)60995-8
  5. 5. Turck CW, Maccarrone G, Sayan-Ayata E, Jacob AM, Ditzen C, Kronsbein H, et al. The quest for brain disorder biomarkers. J Med Invest. 2005; 52(Suppl): 231-235.10.2152/jmi.52.23116366504
  6. 6. Bird A. Perceptions of epigenetics. Nature. 2007; 447(7143): 396-398.10.1038/nature0591317522671
  7. 7. Bird AP. CpG-rich islands and the function of DNA methylation. Nature. 1986; 321(6067): 209-213.10.1038/321209a02423876
  8. 8. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA. 2008; 299(24): 2877-2883.10.1001/jama.299.24.2877258189818577732
  9. 9. Jones PA. Functions of DNA methylation: Islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012; 13(7): 484-492.10.1038/nrg323022641018
  10. 10. Moore LD, Le T, Fan G. DNA Methylation and its basic function. Neuropsychopharmacology. 2013; 38(1): 23-38.10.1038/npp.2012.112352196422781841
  11. 11. Rakyan VK, Down TA, Thorne NP, Flicek P, Kulesha E, Graf S, et al. An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res. 2008; 18(9): 1518-1529.10.1101/gr.077479.108252770718577705
  12. 12. Connor CM, Akbarian S. DNA methylation changes in schizophrenia and bipolar disorder. Epigenetics. 2008; 3(2): 55-58.10.4161/epi.3.2.593818398310
  13. 13. Betcheva ET, Mushiroda T, Takahashi A, Kubo M, Karachanak SK, Zaharieva IT, et al. Casecontrol association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet. 2009; 54(2): 98-107.10.1038/jhg.2008.1419158809
  14. 14. Consortium TIS. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009; 460(7256): 748-752.10.1038/nature08185391283719571811
  15. 15. Kirov G, Pocklington AJ, Holmans P, Ivanov D, Ikeda M, Ruderfer D, et al. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry. 2012; 17(2): 142-153.10.1038/mp.2011.154360313422083728
  16. 16. Raychaudhuri S, Korn JM, McCarroll SA, Altshuler D, Sklar P, Purcell S, et al. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genet. 2010; 6(9): e1001097.10.1371/journal.pgen.1001097293652320838587
  17. 17. Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O’Donovan MC, et al. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry. 2008; 8: 11.10.1186/1471-244X-8-11226868718298822
  18. 18. Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet. 2005; 37(8): 853-862.10.1038/ng159816007088
  19. 19. Jia J, Pekowska A, Jaeger S, Benoukraf T, Ferrier P, Spicuglia S. Assessing the efficiency and significance of Methylated DNA Immunoprecipitation (MeDIP) assays in using in vitro methylated genomic DNA. BMC Res Notes. 2010; 3: 240.10.1186/1756-0500-3-240294966220846371
  20. 20. Down TA, Rakyan VK, Turner DJ, Flicek P, Li H, Kulesha E, et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol. 2008; 26(7): 779-785.10.1038/nbt1414264441018612301
  21. 21. Liekens AM, De Knijf J, Daelemans W, Goethals B, De Rijk P, Del-Favero J. BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation. Genome Biol. 2011; 12(6): R57.10.1186/gb-2011-12-6-r57321884521696594
  22. 22. Watanabe M, Kanbara K. GABA and GABA Receptors in the Central Nervous System and Other Organs, vol. 213. San Diego, CA: Academic Press, 2002.10.1016/S0074-7696(02)13011-7
  23. 23. Liu J, Morgan M, Hutchison K, Calhoun VD. A study of the influence of sex on genome wide methylation. PLoS One. 2010; 5(4): e10028.10.1371/journal.pone.0010028
  24. 24. Canuso CM, Pandina G. Gender and schizophrenia. Psychopharmacol Bull. 2007; 40(4): 178-190.
  25. 25. Bullock WM, Cardon K, Bustillo J, Roberts RC, Perrone-Bizzozero NI. Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia patients. Am J Psychiatry. 2008; 165(12): 1594-1603.10.1176/appi.ajp.2008.07121845
  26. 26. Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, et al. Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia. J Hum Genet. 2013; 58(2): 91-97.10.1038/jhg.2012.140
  27. 27. Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Molec Genet. 2011; 20(24): 4786-4796. 10.1093/hmg/ddr416
  28. 28. Nakai T, Kitamura N, Hashimoto T, Kajimoto Y, Nishino N, Mita T, et al. Decreased histamine H1 receptors in the frontal cortex of brains from patients with chronic schizophrenia. Biol Psychiatry. 1991; 30(4): 349-356.10.1016/0006-3223(91)90290-3
  29. 29. Lee ST, Ryu S, Kim SR, Kim MJ, Kim S, Kim JW, et al. Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response. J Clin Psychopharmacol. 2012; 32(4): 441-448.10.1097/JCP.0b013e31825ac35c22722500
  30. 30. Vehof J, Risselada AJ, Al Hadithy AF, Burger H, Snieder H, Wilffert B, et al. Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. Psychopharmacology (Berlin). 2011; 216(2): 257-265.10.1007/s00213-011-2211-x312194621336576
  31. 31. Gaughran F, Payne J, Sedgwick PM, Cotter D, Berry M. Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. Brain Res Bull. 2006; 70(3): 221-227.10.1016/j.brainresbull.2006.04.00816861106
  32. 32. Bader V, Tomppo L, Trossbach SV, Bradshaw NJ, Prikulis I, Leliveld SR, et al. Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum Mol Genet. 2012; 21(20): 4406-4418.10.1093/hmg/dds273352958522798627
  33. 33. Bornhauser BC, Olsson PA, Lindholm D. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. J Biol Chem. 2003; 278(37): 35412-35420.10.1074/jbc.M306271200
  34. 34. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.Gene. 1996; 180(1-2): 157-163.10.1016/S0378-1119(96)00445-3
  35. 35. Olsson PA, Korhonen L, Mercer EA, Lindholm D. MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. J Biol Chem. 1999; 274(51): 36288-36292.10.1074/jbc.274.51.3628810593918
  36. 36. Soundararajan P, Fawcett JP, Rafuse VF. Guidance of postural motoneurons requires MAPK/ERK signaling downstream of fibroblast growth factor receptor 1. J Neurosci. 2010; 30(19): 6595-6606.10.1523/JNEUROSCI.4932-09.2010663257220463222
  37. 37. Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, et al. Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration. J Neurosci. 2006; 26(51): 13357-13362.10.1523/JNEUROSCI.4276-06.2006667499317182786
  38. 38. Jarskog LF, Glantz LA, Gilmore JH, Lieberman JA. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29(5): 846-858.10.1016/j.pnpbp.2005.03.01015908096
  39. 39. Kerns D, Vong GS, Barley K, Dracheva S, Katsel P, Casaccia P, et al. Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia. Schizophr Res. 2010; 120(1-3): 150-158.10.1016/j.schres.2010.04.01220580881
  40. 40. Catts VS, Catts SV, McGrath JJ, Féron F, McLean D, Coulson EJ, et al. Apoptosis and schizophrenia: A pilot study based on dermal fibroblast cell lines. Schizophr Res. 2006; 84(1): 20-28.10.1016/j.schres.2006.03.01616626937
  41. 41. Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J Biol Chem. 2006; 281(20): 14076-14084.10.1074/jbc.M60065320016567804
  42. 42. Sari Y, Zhou FC. Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice. Alcohol Clin Exp Res. 2004; 28(6): 941-948.10.1097/01.ALC.0000128228.08472.39
  43. 43. Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, et al. Structural basis for the inhibition of Caspase-3 by XIAP. Cell. 2001; 104(5): 791-800.10.1016/S0092-8674(01)00274-4
  44. 44. Meynen G, Unmehopa UA, Hofman MA, Swaab DF, Hoogendijk WJ. Hypothalamic oxytocin mRNA expression and melancholic depression. Mol Psychiatry. 2007; 12(2): 118-119.10.1038/sj.mp.400191117252002
  45. 45. Kyosseva SV. The role of the extracellular signal- regulated kinase pathway in cerebellar abnormalities in schizophrenia. Cerebellum. 2004; 3(2): 94-99.10.1080/1473422041002916415233576
  46. 46. Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, et al. APPL1 Associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol. 2006; 26(23): 8928-8941.10.1128/MCB.00228-06163681517000777
  47. 47. Yano H, Ninan I, Zhang H, Milner TA, Arancio O, Chao MV. BDNF-Mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci. 2006; 9(8): 1009-1018. 10.1038/nn173016819522
Language: English
Page range: 15 - 23
Published on: Apr 10, 2015
Published by: Macedonian Academy of Sciences and Arts
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2015 B. Rukova, R. Staneva, S. Hadjidekova, G. Stamenov, V. Milanova, D. Toncheva, published by Macedonian Academy of Sciences and Arts
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.