HAIR DEPIGMENTATION AND DERMATITIS – AN UNEXPECTED PRESENTATION OF CYSTIC FIBROSIS

Milankov, O.; Savic, R.; Tosic, J.

doi:10.2478/bjmg-2013-0037

Abstract

Hair depigmentation is very rare presentation of cystic fibrosis (CF). We present 3.5-month-old female patient who had dermatitis and depigmentation of hair and eye lashes, malnutrition, edema and anemia as presenting symptoms of CF. After pancreatic enzyme and vitamin supplementation therapy, skin changes gradually disappeared, and her hair regained its normal brown colour

References

1. Salvatore D, Buzzetti R, Baldo E, Forneris M, Lucidi V, Manunza D, et al. An overview of international literature from cystic fibrosis registries. Part 3. Disease incidence, genotype/phenotype correlation, microbiology, pregnancy, clinical complications, lung transplantation, and miscellanea. J Cyst Fibros. 2011; 10(2): 71-85.10.1016/j.jcf.2010.12.005
Search in Google Scholar
2. Nielsen OH, Larsen BF. The incidence of anemia, hypoproteinemia, and edema in infants as presenting symptoms of cystic ﬁbrosis: A retrospective survey of the frequency of this symptom complex in 130 patients with cystic ﬁbrosis. J Pediatr Gastroenterol Nutr. 1982; 1(3): 355-359.10.1097/00005176-198201030-00013
Search in Google Scholar
3. Fustik S, Jacovska T, Spirevska L, Koceva S. Protein- energy malnutrition as the ﬁrst manifestation of cystic ﬁbrosis in infancy. Pediatr Int. 2009; 51(5): 678-683.10.1111/j.1442-200X.2009.02855.x
Search in Google Scholar
4. Darmstadt L, McGuire J, Ziboh A. Malnutritionassociated rash of cystic fibrosis. Pediatr Dermatol. 2000; 17(5): 337-347.10.1046/j.1525-1470.2000.017005337.x
Search in Google Scholar
5. Wenk K, Higgins K, Greer K. Cystic fibrosis presenting with dermatitis. Arch Dermatol. 2010; 146(2): 171-174.10.1001/archdermatol.2009.361
Search in Google Scholar
6. Mei-Zahav M, Solomon M, Kawamura A, Coates A, Durie P. Cystic fibrosis presenting as kwashiorkor in a Sri Lankan infant. Arch Dis Child. 2003; 88(8): 724-725.10.1136/adc.88.8.724
Search in Google Scholar
7. Dalgic B, Egritas O. Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. Eur J Pediatr. 2011; 170(10): 1305-1308.10.1007/s00431-011-1447-0
Search in Google Scholar
8. Lovett A, Kokta V, Maari C. Diffuse dermatitis: An unexpected initial presentation of cystic fibrosis. J Am Acad Dermatol. 2008; 58(2): S1-S4.10.1016/j.jaad.2006.04.012
Search in Google Scholar
9. Oshikoya KA, Senbanjo IO. Pathophysiological changes that affect drug disposition in proteinenergy malnourished children. Nutrit Metab. 2009; 6(1): 50-57.10.1186/1743-7075-6-50
Search in Google Scholar
10. Phillips RJ, Crock CM, Dillon MJ, Clazton PT, Curran A, Harper JI. Cystic fibrosis presenting as kwashiorkor with florid skin rash. Arch Dis Child. 1993; 69(4): 446-448.10.1136/adc.69.4.446
Search in Google Scholar
11. Crone J, Huber WD, Eichler I, Granditsch G. Acrodermatitis enteropathica-like eruption as the presenting sign of cystic fibrosis-case report and review of the literature. Eur J Pediatr. 2002; 161(9): 475-478.10.1007/s00431-002-0982-0
Search in Google Scholar
12. Muniz AE, Bartle S, Foster R. Edema, anemia, hypoproteinemia and acrodermatitis enteropathica: an un-common initial presentation of cystic fibrosis. Pediatr Emerg Care. 2004; 20(2): 112-114.10.1097/01.pec.0000113881.10140.50
Search in Google Scholar

HAIR DEPIGMENTATION AND DERMATITIS – AN UNEXPECTED PRESENTATION OF CYSTIC FIBROSIS

Abstract

Paradigm

My account