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Stationary distribution and extinction in the stochastic model of human immune system response to COVID-19 virus under regime switching Cover

Stationary distribution and extinction in the stochastic model of human immune system response to COVID-19 virus under regime switching

Open Access
|Apr 2025

Abstract

In this paper, in order to study effects of the human immune system response to spread of COVID-19 virus, we establish a stochastic competition model between immune cells and COVID-19 particles by introducing both white and coloured noise. We first prove the existence and uniqueness of the global positive solution of the system under consideration. Furthermore, the stationary distribution and ergodicity of the system are investigated in order to prove weak persistence in mean. We also obtain the conditions for extinction of the disease. The obtained results are related to basic reproduction number of the corresponding deterministic analogue of the system. Finally, we provide numerical simulations with real life data to support theoretical conclusions obtained in the paper.

DOI: https://doi.org/10.2478/auom-2025-0011 | Journal eISSN: 1844-0835 | Journal ISSN: 1224-1784
Language: English
Page range: 215 - 238
Submitted on: Nov 17, 2023
Accepted on: Feb 7, 2024
Published on: Apr 2, 2025
Published by: Ovidius University of Constanta
In partnership with: Paradigm Publishing Services
Publication frequency: 3 issues per year

© 2025 Marija Krstić, Vuk Vujović, Milica Marković, published by Ovidius University of Constanta
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.