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Microwave assisted synthesis and evaluation of antimalarial potencies of some 8-quinoline enones Cover

Microwave assisted synthesis and evaluation of antimalarial potencies of some 8-quinoline enones

Ovidius University Annals of Chemistry
Volume 36 (2025): Issue 1 (January 2025)
By: Pannerselvam Gayathri,  Inbasekaran Muthuvel,  Perumal Mayavel,  Kaliyaperumal Ranganathan,  Veeramalai Usha,  Veerandiran Mala and  Ganesamoorthy Thirunarayanan  
Open Access
|Jun 2025

References

  1. N. Suresh, H. N. Nagesh, J. Renuka, V. Rajput, R. Sharma, I. A. Khan, C. S. K. V. Gowri, Synthesis and evaluation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2-(4-substitutedpiperazinyl)acetyl)piperazin-1-yl) quinoline-3-carboxylic acid derivatives as anti-tubercular and antibacterial agents, European Journal of Medicinal Chemistry 71 (2014) 324-332.
    Search in Google ScholarBack to article
  2. M. Sekar, K.J.R. Prasad, Synthesis of some novel 2-oxo-pyrano(2,3-b)- and 2-oxo-pyrido(2,3-b) quinoline derivatives as potential antimalarial, diuretic, clastogenic and antimicrobial agents, Journal of Chemistry Technology and Biotechnology 72 (1998) 50-54.
    Search in Google ScholarBack to article
  3. C.M. Hall, H.G. Johnson, J.B. Wright, A.J. Taylor, Quinoline derivatives as antiallergy agents. 2. Fused-ring quinaldic acids, Journal of Medicinal Chemistry 20 (1977) 1337-1343.
    Search in Google ScholarBack to article
  4. G. Roma, G. Grossi, M.D. Braccio, D. Piras, V. Ballabeni, M. Tognolini, S. Bertoni, E. Barocelli, 1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo [4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity, European Journal of Medicinal Chemistry 43 (2008) 1665-1680.
    Search in Google ScholarBack to article
  5. V. Mala, I. Muthuvel, G. Thirunarayanan, S.P. Sakthinathan, R. Arulkumaran, V. Mani, R. Sundararajan, D. Kamalakkannan, R. Suresh, V. Usha, Ultrasound assisted synthesis and pharmacological evaluation of some (E)-1,2,3-triphenylprop-2-en-1-ones, Ovidius University Annals of Chemistry 31 (2020)152-157.
    Search in Google ScholarBack to article
  6. A. Marella, O.P. Tanwar, R. Saha, M.R. Ali, S. Srivastava, M. Akhter, M. Shaquiquzzaman, M. M. Alam, Quinoline: A versatile heterocyclic, Saudi Pharmaceutical Journal 21 (2013) 1-12.
    Search in Google ScholarBack to article
  7. B.A. Hathaway, Aldol condensation experiment using a number of aldehydes and ketones, Journal of Chemical Education 64 (1987) 367-368.
    Search in Google ScholarBack to article
  8. D. Kamalakkannan, R. Senbagam, G. Vanangamudi, G. Thirunarayanan, Synthesis and assessment of substituent effect of some 3-((E)-3-substituted phenylacryloyl) benzonitriles, Journal of Molecular Structure 1264 (2022) 133218. DOI: 10.1016/j.molstruc.2022.133218.
    Search in Google ScholarBack to article
  9. N.A.B. Syed, J. Malina, J. Ibrahim, A. Waqas, Review of methods and various catalysts used for chalcone synthesis, Mini-Reviews in Organic Chemistry 10 (2013) 73-83
    Search in Google ScholarBack to article
  10. S. Saravanamurugan, M. Palanichamy, A. Banumathi, V. Murugesan, Solvent free synthesis of chalcone and flavanone over zinc oxide supported metal oxide catalysts, Catalysis Communications 9 (2005) 399-403.
    Search in Google ScholarBack to article
  11. I. Muthuvel, S. Dineshkumar, K. Thirumurthy, B. Krishnakumar, G. Thirunarayanan, A new solid acid catalyst bentonite/FeCl3 for aldol condensation under solvent-free condition, Indian Journal of Chemistry 55B (2016) 252-260.
    Search in Google ScholarBack to article
  12. K.D. Dhawale, A.P. Ingale, M.S. Pansare, S.S. Gaikwa, N.M. Thorat, L.R. Pati, Sulfated tungstate as a heterogeneous catalyst for synthesis of 3-functionalized coumarins under solvent-free Conditions, Polycyclic Aromatic Compounds 43 (2023) 3588–3600.
    Search in Google ScholarBack to article
  13. G. Thirunarayanan, P. Mayavel, K. Thirumurthy, Fly-ash:H2SO4 catalyzed solvent free efficient synthesis of some aryl chalcones under microwave irradiation, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 91 (2012) 18-22.
    Search in Google ScholarBack to article
  14. V. Mala, I. Muthuvel, G. Thirunarayanan, V. Usha, Catalytic effect of nano cadmium phosphate catalyst on the synthesis of some (E)-3,4-dimethoxyphenylprop-2-en-1-ones, Materials Today Proceedings 43 (2021) 2117-2122.
    Search in Google ScholarBack to article
  15. G. Thirunarayanan, G. Vanangamudi, Synthesis of some 4-bromo-1-naphthyl chalcones using silica-sulfuric acid reagent under solvent free conditions, Arkivoc 12 (2006) 58-64
    Search in Google ScholarBack to article
  16. K. G. Sekar, P. Janaki, I. Muthuvel, V. Usha, K. Thirumurthy, G. Thirunarayanan, Catalytic behaviour of solid acidic SO42--SnO2-fly ash peony flower like nano catalyst on the synthesis of some E-Pyrenyl enones, Materials Today Proceedings 43 (2021) 2208-2214.
    Search in Google ScholarBack to article
  17. I. Muthuvel, G. Thirunarayanan, V. Thangaraj, N. Sundaramurthy, S. Rajalakshmi, V. Usha, Study of catalytic activity of Zn3(PO4)2 on the synthesis of some pyrenyl enones, Materials Today Proceedings 43 (2021) 2203-2207.
    Search in Google ScholarBack to article
  18. K. Ranganathan, D. Kamalakkannan, R Suresh, SP. Sakthinathan, R. Arulkumaran, R. Sundararajan, V. Manikandan, P. Venkatachalam, S. Rajalakshmi, I. Muthuvel, G. Thirunarayanan, Cu2+/Zeolite catalyzed Aldol condensation: Greener synthesis of 4′-piperidinophenyl enones, Materials Today Proceedings 22 (2020) 1196-1199.
    Search in Google ScholarBack to article
  19. S. Balaji, V. Manikandan, M. Rajarajan, V. Usha, S. Rajalakshmi, P. Venkatachalam, I. Muthuvel, G. Thirunarayanan, Investigation of catalytic activity of solid acidic FeCl3/Bentonite catalyst on the synthesis of some (E)-1-(2,4-Dimethylthiazol-5-yl)-3-phenylprop-2-en-1-ones by solvent-free technique, Materials Today Proceedings 22 (2020) 931-936.
    Search in Google ScholarBack to article
  20. C. Geetha, P. R. Rajakumar, P. Christuraj, V. Manikandan, R. Arulkumaran, G. Thirunarayanan, Synthesis, spectral correlation study, antibacterial and antifungal activities of substituted 5-(4-fluorophenyl)-3-phenylisoxazoles, Journal of Advanced Scientific Research 10(4) (2019) 156-166.
    Search in Google ScholarBack to article
  21. G. Thirunarayanan, K. G. Sekar, Solvent-free onepot cyclization and acetylation of chalcones: Synthesis of some 1-acetylpyrazoles and spectral correlations of 1-(3-(3,4-dimethylphenyl)-5-substitutedphenyl)-4,5-dihydro-1H-pyrazole-1-yl) ethanones, Journal of Saudi Chemical Society 20 (2016) 661-672.
    Search in Google ScholarBack to article
  22. R. Arulkumaran, R. Sundararajan, V. Manikandan, V. Sathiyendiran, S. Pazhamalai, G. Thirunarayanan, IR and 1H NMR spectral studies of some 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamides: Assessment of substituent effects, International Letters of Chemistry, Physics and Astronomy 38 (2014) 15-25.
    Search in Google ScholarBack to article
  23. E. Rizk Khidre, R. Sameh, E. Gogary, S. Mohamed, Mostafa, Design, Synthesis, and antimicrobial evaluation of some novel pyridine, coumarin, and thiazole derivatives, Journal of Heterocyclic Chemistry 54 (2017) 2511–2319.
    Search in Google ScholarBack to article
  24. W.M. Abdou, R.E. Khidre, A.A. Kamel, Elaborating on efficient anti-proliferation agents of cancer cells and anti-inflammatory-based N-bisphosphonic acids, Arch Pharm Chemistry in Life Sciences 345 (2012) 123-136.
    Search in Google ScholarBack to article
  25. F.J. Smit, D.D. N’da, Synthesis in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides, Bioorganic & Medicinal Chemistry 22 (2014) 1128-1138.
    Search in Google ScholarBack to article
  26. R. Abonia, D. Insuasty, J. Castillo, B. Insuasty, J. Quiroga, M. Nogueras, J. Cobo. Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity, European Journal of Medicinal Chemistry 57 (2012) 29-40.
    Search in Google ScholarBack to article
  27. S.U.F. Rizvi, H.L. Siddiqui, M.N. Ahmad, M. Ahmad, M.H. Bukhari, Novel quinolyl-thienyl chalcones and their 2-pyrazoline derivatives with diverse substitution pattern as antileishmanial agents, against Leishmania major, Medicinal Chemistry Research 21 (2012) 1322-1333.
    Search in Google ScholarBack to article
  28. R. Arulkumaran, R. Sundararajan, G. Vanangamudi, M. Subramanian, K. Ravi, V. Sathiyendiran, S. Srinivasan, G. Thirunarayanan, Infrared spectral linearity of some anti-plasmodial potent chalcones, IUP Journal of Chemistry 3 (2010) 82-98.
    Search in Google ScholarBack to article
  29. A. Kharazmi, M. Chen, T. Theander, S.B. Christensen, Discovery of oxygenated chalcones as novel antimalarial agents, Annals of Tropical Medicine and Parasitology 91 (1997) 91–95.
    Search in Google ScholarBack to article
  30. S. Eswaran, A. Vasudeva, A. Imran, H. Chowdhury, N.K. Pal, K. Thomas, New quinoline derivatives: synthesis and investigation of antibacterial and antituberculosis properties, European Journal of Medicinal Chemistry 45 (2010) 3374–83.
    Search in Google ScholarBack to article
  31. M. L. Go, Novel antiplasmodial agents, Medicinal Research Reviews 23 (2003) 456-487.
    Search in Google ScholarBack to article
  32. P. Cheng, L. Yang, X. Huang, X. Wang, M. Gong, Chalcone hybrids and their antimalarial activity, Arch Pharm Chemistry in life Sciences 353 (2020) 353, 1900350. DOI: 10.1002/ardp.201900350
    Search in Google ScholarBack to article
  33. S. Sinha, B. Medhi, B.D. Radotra, D.I. Batovska, N. Markova, A. Bhalla, R. Sehgal, Antimalarial and immunomodulatory potential of chalcone derivatives in experimental model of malaria. BMC Complementary Medicine and Therapies 22 (2022) 330. DOI: 10.1186/s12906-022-03777-w.
    Search in Google ScholarBack to article
  34. S. John Joseph, K. Ranganathan, R. Suresh, R. Arulkumaran, R. Sundararajan, D. Kamalakkannan, S.P. Sakthinathan, G. Vanangamudi, S. Dineshkumar, K. Thirumurthy, I. Muthuvel, G. Thirunarayanan, K. Viveksarathi, Synthesis, characterization and synthetic applications of fly-ash:H3PO4 nanocatalyst, Material Science and Applied Chemistry 34 (2017) 12-20.
    Search in Google ScholarBack to article
  35. V. Boobal Arasu, G. Thirunarayanan, I. Muthuvel, S. Kulanthaivel, Effect of Fly-ash:H3PO4 nano catalyst on the synthesis of piperazinyl carbothioamide, Materials Today Proceedings in press. DOI: 10.1016/j.matpr.2023.05.170.
    Search in Google ScholarBack to article
  36. A. Valla, B. Valla, D. Cartier, R.L. Guillou, R. Labia, L. Florent, S. Charneau, J. Schrevel, P. Potier, New syntheses and potential antimalarial activities of new retinoid-like chalcones, European Journal of Medicinal Chemistry 41 (2006) 142-146.
    Search in Google ScholarBack to article
  37. A.K. Maji, Drug susceptibility testing methods of antimalarial agents, Tropical Parasitology 8 (2018) 70–76.
    Search in Google ScholarBack to article
DOI: https://doi.org/10.2478/auoc-2025-0008 | Journal eISSN: 2286-038X | Journal ISSN: 1583-2430
Journal RSS Feed
Language: English
Page range: 66 - 72
Submitted on: Apr 6, 2025
|
Accepted on: Jun 11, 2025
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Published on: Jun 25, 2025
Published by: Ovidius University of Constanta
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
8-quinoline enones,
nano fly-ash:H3PO4,
crossed-aldol condensation,
microwave irradiation,
IR spectra,
NMR spectra,
anti-malarial activity
Related subjects:
Chemistry,
Chemistry, other

© 2025 Pannerselvam Gayathri, Inbasekaran Muthuvel, Perumal Mayavel, Kaliyaperumal Ranganathan, Veeramalai Usha, Veerandiran Mala, Ganesamoorthy Thirunarayanan, published by Ovidius University of Constanta
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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