Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Rajendran Venkatraman; Jaganathan Divya; Pannerselvam Gayathri; Ganesamoorthy Thirunarayanan; Inbasekaran Muthuvel

doi:10.2478/auoc-2024-0005

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Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Ovidius University Annals of Chemistry

Volume 35 (2024): Issue 1 (January 2024)

By: Rajendran Venkatraman, Jaganathan Divya, Pannerselvam Gayathri, Ganesamoorthy Thirunarayanan and Inbasekaran Muthuvel

Open Access

|Jun 2024

Abstract

The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the in vitro antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.

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Articles in this issue

DOI: https://doi.org/10.2478/auoc-2024-0005 | Journal eISSN: 2286-038X | Journal ISSN: 1583-2430

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Language: English

Page range: 36 - 42

Submitted on: Aug 4, 2023

Accepted on: Apr 20, 2024

Published on: Jun 7, 2024

Published by: Ovidius University of Constanta

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

antibacterial activity

Related subjects:

Chemistry,

Chemistry, other

© 2024 Rajendran Venkatraman, Jaganathan Divya, Pannerselvam Gayathri, Ganesamoorthy Thirunarayanan, Inbasekaran Muthuvel, published by Ovidius University of Constanta
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 35 (2024): Issue 1 (January 2024)