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From ancient roots to modern routes: a systematic review of ginger’s anti-motion sickness efficacy in randomized clinical trials and animal studies Cover

From ancient roots to modern routes: a systematic review of ginger’s anti-motion sickness efficacy in randomized clinical trials and animal studies

Open Access
|Mar 2026

References

  1. BETZ O., KRANKE P., GELDNER G., WULF H., EBERHART L.H., 2005 - Ist Ingwer ein klinisch relevantes Antiemetikum? Eine systematische übersicht randomisierter kontrollierter Studien (Is ginger a clinically relevant antiemetic? A systematic review of randomized controlled trials). Forschende Komplement ä rmedizin und Klassische Naturheilkunde (Research in Complementary and Classical Natural Medicine) 12(1), 14-23.
  2. BRYER E., 2005 - A literature review of the effectiveness of ginger in alleviating mild-to-moderate nausea and vomiting of pregnancy. Journal of Midwifery and Women ’ s Health 50(1), e1-e3.
  3. CHOI J., LEE J., KIM K., CHOI H.K., LEE S.A., LEE H.J., 2022 - Effects of ginger intake on chemotherapy-induced nausea and vomiting: a systematic review of randomized clinical trials. Nutrients 14(23), 4982.
  4. CRICHTON M., MARSHALL S., MARX W., MCCARTHY A.L., ISENRING E., 2019 - Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic review update and meta-analysis. Journal of the Academy of Nutrition and Dietetics 119(12), 2055-2068.
  5. DING M., LEACH M., BRADLEY H., 2013 - The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review. Women and Birth 26(1), e26-e30.
  6. FLEMYNG E., DWAN K., MOORE T.H., PAGE M.J., HIGGINS J.P., 2020 - Risk of bias 2 in cochrane reviews: a phased approach for the introduction of new methodology. Cochrane Database of Systematic Review 10(11), ED000148.
  7. GIANAROS P.J., MUTH E.R., MORDKOFF J.T., LEVINE M.E., STERN R.M., 2001 - A questionnaire for the assessment of the multiple dimensions of motion sickness. Aviation, Space, and Environmental Medicine 72(2), 115-119.
  8. GOLDING J.F., 2006 - Motion sickness susceptibility. Autonomic Neuroscience: Basic and Clinical 129(1-2), 67-76.
  9. GRØNTVED A., BRASK T., KAMBSKARD J., HENTZER E., 1988 - Ginger root against seasickness: a controlled trial on the open sea. Acta Oto-Laryngologica 105(1-2), 45-49.
  10. HA N.Y., PARK M.J., KO S.J., PARK J.W., KIM J., 2024 - Effect of herbal medicine on postoperative nausea and vomiting after laparoscopic surgery: a systematic review and meta-analysis. Medicine 103(23), e38334.
  11. HIGGINS J.P., ALTMAN D.G., GØTZSCHE P.C., JÜNI P., MOHER D., OXMAN A.D., SAVOVIC J., SCHULZ K.F., WEEKS L., STERNE J.A., 2011 - The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. British Medical Journal 343:d5928.
  12. HOLTMANN S., CLARKE A.H., SCHERER H., HÖHN M., 1989 - The anti-motion sickness mechanism of ginger: a comparative study with placebo and dimenhydrinate. Acta Oto-Laryngologica 108(3-4), 168-174.
  13. KIYAMA R., 2020 - Nutritional implications of ginger: chemistry, biological activities and signaling pathways. Journal of Nutritional Biochemistry 86, 108486.
  14. LACKNER J.R., 2014 - Motion sickness: more than nausea and vomiting. Experimental Brain Research 232(8), 2493-2510.
  15. LEUNG A.K., HON K.L., 2019 - Motion sickness: an overview. Drugs in Context 8, 2019-9-4.
  16. LIEN H.C., SUN W.M., CHEN YH., KIM H., HASLER W., OWYANG C., 2003 - Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. American Journal of Physiology – Gastrointestinal and Liver Physiology 284(3), G481–G489.
  17. MAO Q.Q., XU X.Y., CAO S.Y., GAN R.Y., CORKE H., BETA T., LI H.B., 2019 - Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods 2019 8(6), 185.
  18. MATIN M., KAPOOR B., GULATI M., MICKAEL M.E., MATIN F.B., KAMIŃSKA A., ET AL. 2025 - Exploring the innovation landscape of ginger: insights from patent documentation analysis. Current Research in Biotechnology 9, 100299.
  19. MOWREY D.B., CLAYSON D.E., 1982 - Motion sickness, ginger, and psychophysics. The Lancet 1(8273), 655-657.
  20. MURDIN L., GOLDING J.F., BRONSTEIN A.M., 2011 - Managing motion sickness. British Medical Journal 343, d7430.
  21. NUNES C.P., RODRIGUES C.C., CARDOSO C.A.F., CYTRYNBAUM N., KAUFMAN R., RZETELNA H., GOLDWASSER G., SANTOS A., OLIVEIRA L., GELLER M., 2020 - Clinical evaluation of the use of ginger extract in the preventive management of motion sickness. Current Therapeutic Research – Clinical and Experimental 92, 100591.
  22. NUNES C.P., RODRIGUES C.C., SUCHMACHER M., ESTEVES C.R., GONÇALVES K., RZETELNA H., ET AL. 2023 - A combination of gamma-aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine, and cyanocobalamin vs ginger extract in the management of chronic motion sickness: a clinical evaluation. Current Therapeutic Research – Clinical and Experimental 99, 100719.
  23. PAILLARD A., JACQUOT L., MILLOT J.L., 2011 - Olfactory perception and motion sickness. Chemical Senses 36(8):E35-E36.
  24. PAILLARD A.C., QUARCK G., PAOLINO F., DENISE P., PAOLINO M., GOLDING J.F., 2013 - Motion sickness susceptibility in healthy subjects and vestibular patients: effects of gender, age, and trait anxiety. Journal of Vestibular Research: Equilibrium and Orientation 23(4-5), 203-209.
  25. PALATTY P.L., HANIADKA R., VALDER B., ARORA R., BALIGA M.S., 2013 - Ginger in the prevention of nausea and vomiting: a review. Critical Reviews in Food Science and Nutrition 53(7), 659-669.
  26. RAHIMZADEH G., TAY A, TRAVICA N., LACY K., MOHAMED S., NAHAVANDI D., PŁAWIAK P., QAZANI M.C., ASADI H., 2023 - Nutritional and behavioral countermeasures as medication approaches to relieve motion sickness: a comprehensive review. Nutrients 7, 15(6), 1320.
  27. ROLNICK A., LUBOW R.E., 1991 - Why is the driver rarely motion sick? The role of controllability in motion sickness. Ergonomics 34(7), 867-879.
  28. SABERI F., SADAT Z., ABEDZADEH-KALAHROUDI M., TAEBI M., 2014 - Effect of ginger on relieving nausea and vomiting in pregnancy: a randomized, placebo-controlled trial. Nursing and Midwifery Studies 3(1), e11841.
  29. SHARMA K. APARNA 1997 - Prevalence and correlates of susceptibility to motion sickness. Acta Geneticae Medicae et Gemellologiae 46(2), 105-121.
  30. SHUPAK A., GORDON C.R., 2006 - Motion sickness: advances in pathogenesis, prediction, prevention, and treatment. Aviation, Space, and Environmental Medicine 77(12), 1213-1223.
  31. SPINKS A., WASIAK J., 2011 - Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database of Systematic Reviews (6), CD002851.
  32. STERNE J.A.C., SAVOVIĆ J., PAGE M.J., ELBERS R.G., BLENCOWE N.S., BOUTRON I., CATES C.J., CHENG H.Y., CORBETT M.S., ELDRIDGE S.M., EMBERSON J.R., HERNÁN M.A., HOPEWELL S., HRÓBJARTSSON A., JUNQUEIRA D.R., JÜNI P., KIRKHAM J.J., LASSERSON T., LI T., MCALEENAN A., REEVES B.C., SHEPPERD S., SHRIER I., STEWART L.A., TILLING K., WHITE I.R., WHITING P.F., HIGGINS J.P.T. 2019 - RoB 2: a revised tool for assessing risk of bias in randomised trials. British Medical Journal 366, l4898.
  33. TARIQ M., KHAN S.A., MALIK M.S.A., CHANDIO M.A., 2024 -The impact of ginger on alleviating motion sickness. Pakistan Armed Forces Medical Journal 74(SUPPL-2), S179-S183.
  34. TÓTH B., LANTOS T., HEGYI P., VIOLA R., VASAS A., BENKŐ R., GYÖNGYI Z., VINCZE Á., CSÉCSEI P., MIKÓ A., HEGYI D., SZENTESI A., MATUZ M., CSUPOR D., 2018 - Ginger (Zingiber officinale): an alternative for the prevention of postoperative nausea and vomiting: a meta-analysis. Phytomedicine. International Journal of Phytotherapy and Phytopharmacology 50, 8-18.
  35. WEERTS A.P., PATTYN N., VAN DE HEYNING P.H., WUYTS F.L., 2014 - Evaluation of the effects of anti-motion sickness drugs on subjective sleepiness and cognitive performance of healthy males. Journal of Psychopharmacology 28(7), 655-664.
  36. YARNELL E., 2016 - Herbs for motion sickness. Alternative and Complementary Therapies 22(2), 1-5.
  37. ZHONG W., ZHU J., YI J., ZHAO C., SHI Y., KANG Q., HUANG J., HAO L., LU J., 2022 -Biochemical analysis reveals the systematic response of motion sickness mice to ginger (Zingiber officinale) extract’s amelioration effect. Journal of Ethnopharmacology 290, 115077.
Language: English
Page range: 1 - 16
Accepted on: Feb 24, 2026
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Published on: Mar 28, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 ArunSundar Mohana Sundaram, Murali Krishna Kandukuri, Keerthana Bharathi, Richel Pooja Maram Rock, Bharathi Sridhar, Naveen Akshinthala Purushotham, Vijaya Kumar Voleti, Meng-Yao Li, Maima Matin, Atanas G. Atanasov, published by Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.