Have a personal or library account? Click to login

Assessment of spatiotemporal development of cell lineages in the mouse blastocyst using bespoke cell neighbourhood analysis approaches

Open Access
|Oct 2025

References

  1. BORLAND R.M., BIGGERS J.D., LECHENE C.P., 1977 – Studies on the composition and formation of mouse blastocoele fluid using electron probe microanalysis. Developmental Biology 55, 1-8.
  2. CHAZAUD C., YAMANAKA Y., PAWSON T., ROSSANT J., 2006 – Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the grb2-MAPK pathway. Developmental Cell 10, 615-624.
  3. CHRISTODOULOU N., WEBERLING A., STRATHDEE D., ANDERSON K.I., TIMPSON P., ZERNICKA-GOETZ M., 2019 – Morphogenesis of extra-embryonic tissues directs the remodeling of the mouse embryo at implantation. Nature Communications 10, 3557.
  4. COPP A.J., 1978 – Interaction between inner cell mass and trophectoderm of the mouse blastocyst. I. A study of cellular proliferation. Journal of Embryology and Experimental Morphology 48, 109-125.
  5. DE MOT L., GONZE D, BESSONARD S., CHAZAUD C., GOLDBETER A., DUPONT G., 2016 – Cell fate specification based on tristability in the inner cell mass of mouse blastocysts. Biophysics Journal 110, 710-722.
  6. FILIMONOW K., DE LA FUENTE R., 2022 – Specification and role of extraembryonic endoderm lineages in the periimplantation mouse embryo. Theriogenology 180, 189-206.
  7. FILIMONOW K., SAIZ N., SUWIŃSKA A., WYSZOMIRSKI T., GRABAREK J.B., FERRETTI E., PILISZEK A., PLUSA B., MALESZEWSKI M., 2019 – No evidence of involvement of E-cadherin in cell fate specification or the segregation of Epi and PrE in mouse blastocysts. PLoS One 14, e0212109.
  8. FISCHER S.C., CORUJO-SIMON E., LILAO-GARZON J., STELZER E.H.K., MUÑOZDESCALZO S., 2020 – The transition from local to global patterns governs the differentiation of mouse blastocysts. PLoS ONE 15, e0233030.
  9. FORSYTH J.E., AL-ANBAKI A.H., DE LA FUENTE R., MODARE N., PEREZ-CORTES D., RIVERA I., KELLY R.S., COTTER S., PLUSA B., 2021 – IVEN: A quantitative tool to describe 3D cell position and neighbourhood reveals architectural changes in FGF4-treated preimplantation embryos. PLoS Biology 7, e3001345.
  10. FULTON B.P., WHITTINGHAM D.G., 1978 – Activation of mammalian oocytes by intracellular injection of calcium. Nature 273, 149-151.
  11. GRABAREK J.B., PLUSA B., 2012 – Live imaging of primitive endoderm precursors in the mouse blastocyst. Methods in Molecular Biology 916, 275-285.
  12. LOU X., KANG M., XENOPOULOS P., MUNOZ-DESCALZO S., HADJANTONAKIS A.K., 2014 – A rapid and efficient 2D/3D nuclear segmentation method for analysis of early mouse embryo and stem cell image data. Stem Cell Reports 2, 382-397.
  13. MANEJWALA F.M., CRAGOE JR. E.J., SCHULTZ R.M., 1989 – Blastocoel expansion in the preimplantation mouse embryo: role of extracellular sodium and chloride and possible apical routes of their entry. Developmental Cell 133, 210-220.
  14. MCLAREN A., SMITH R., 1977 – Functional test of tight junctions in the mouse blastocyst. Nature 267, 351-353.
  15. NICOLSON G.L., YANAGIMACHI R., YANAGIMACHI H., 1975 – Ultrastructural lozalization of lectin-binding sites on the zonae pellucidae and plasma membranes of mammalian eggs. Journal of Cell Biology 66, 263-274.
  16. NISHIOKA N., INOUE K., ADACHI K., KIYONARI H., OTA M., RALSTON A., YABUTA N., HIRAHARA S., STEPHENSON R.O., OGONUKI N., MAKITA R., KURIHARA H., MORINKENSICKI E.M., NOJIMA H., ROSSANT J., NAKAO K., NIWA H., SASAKI H., 2009 – The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Developmental Cell 16, 398-410.
  17. NIWA H., TOYOOKA Y., SHIMOSATO D., STRUMPF D., TAKAHASHI K., YAGI R., ROSSANT J., 2005 – Interaction between Oct3/3 and Cdx2 determines trophectoderm differentiation. Cell 123, 917-929.
  18. PLUSA B., PILISZEK A., FRANKENBERG S., ARTUS J., HADJANTONAKIS A.K., 2008 – Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development 135, 3081-3091.
  19. RAINA D., BAHADORI A. STANOEV A., PROTZEK M., KOSESKA. SCHRÖTER C., 2021 – Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells. Development 148, dev.199926.
  20. SAIZ N., GRABAREK J.B., SABHERWAL N., PAPALOPULU N., PLUSA B., 2013 – Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst. Development 140, 4311-4322.
  21. SAIZ N., MORA-BITRIA L., RAHMAN S., GEORGE H., HERDER J., GARCIA-OJALVO J., HADJANTONAKIS A.K., 2020 – Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development. eLife 9, e56079.
  22. SAIZ N., WILLIAMS K.M., SESHAN V.E., HADJANTONAKIS A.K., 2016 – Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst. Nature Communications 7, 13463.
  23. SCHLIFFKA M.F., DUMORTIER J.G., PELZER D., MUKHERJEE A., MAÎTRE J.J., 2024 – Inverse blebs operate as hydraulic pumps during mouse blastocyst formation. Nature Cell Biology doi: 10,1038/s41556-024-01501-z.
  24. STRAWBRIDGE S.E., KUROWSKI A., CORUJO-SIMON E., FLETCHER A.N., NICHOLS J., FLETCHER A.G., 2023 – insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology. Biology Open 12, bio060055.
  25. STRUMPF D., MAO C.A., YAMANAKA Y., RALSTON A., CHAWENGSAKSOPHAK K., BECK F., ROSSANT J., 2005 – Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132, 2093-2102.
  26. SUTHERLAND A.E., SPEED T.P., Calarco P.G., 1990 – Inner cell allocation in the mouse morula: the role of oriented division during fourth cleavage. Developmental Biology 137, 13-25.
  27. TOSENBERG A., GONZE D., BESSONARD S., COHEN-TANNOUDJI M., CHAZAUD C., CUPONT G., 2017 – A multiscale model of early cell lineage specification including cell division. NPJ Systems Biology and Applications 3, 16.
  28. VELTMAAT J.M., ORELIO C.C., WARD-VAN OOSTWAARD D., VAN ROOIJEN M.A., MUMMERY C.L., DEFIZE L.H., 2000 – Snail is an intermediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation. The International Journal of Developmental Biology 44, 297-307.
  29. WILEY L.M., 1984 – Cavitation in the mouse preimplantation embryo: Na/K-ATPase and the origin of nascent blastocoele fluid. Developmental Biology 105, 330-342.
  30. YAMANAKA Y., RALSTON A., STEPHENSON R.O., ROSSANT J., 2006 – Cell and molecular regulation of the mouse blastocyst. Developmental Dynamics 235, 2301-2314.
  31. YANAGIDA A., CORUJO-SIMON E., REVELL C.K., SAHU P., STIRPARO G.G., ASPALTER I.M., WINKEL A.K., PETERS R., DE BELLY H., CASSANI D.A.D., ACHOURI S., BLUMENFELD R., FRANZE K., HANNEZO E., PALUCH E.K., NICHOLS J., CHALUT K.J., 2022 – Cell surface fluctuations regulate early embryonic lineage sorting. Cell 185, 1258
Language: English
Page range: 347 - 366
Accepted on: May 26, 2025
Published on: Oct 7, 2025
Published by: Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Roberto de la Fuente, Jessica E. Forsyth, published by Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.