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The occurrence of changes in mitochondrial tRNA-Leu (UUR) gene and its methylation profil in dogs with malignant tumours Cover

The occurrence of changes in mitochondrial tRNA-Leu (UUR) gene and its methylation profil in dogs with malignant tumours

Open Access
|Jul 2025

References

  1. BARANOWSKA I., JÄDERLUND K. H., NENNESMO I., HOLMQVIST E., HEIDRICH N., LARSSON N. G., ANDERSSON G., WAGNER E. G. H., HEDHAMMAR Å., WIBOM R., ANDERSSON L., 2009 - Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene. PLOS Genetics 5(5).
  2. BELLIZZI D., D’AQUILA P., SCAFONE T., GIORDANO M., RISO V., RICCIO A., PASSARINO G., 2013 - The control region of mitochondrial DNA shows an unusual CpG and Non-CpG methylation pattern. DNA Research 20(6), 537-547.
  3. BERTAGNOLLI A. C., SOARES P., VAN ASCH B., AMORIM A., CIRNES L., MÁXIMO V., CASSALI G. D., 2009 - An assessment of the clonality of the components of canine mixed mammary tumours by mitochondrial DNA analysis. The Veterinary Journal 182(2), 269-274.
  4. BRANDÃO Y. DE O., TOLEDO M. B., CHEQUIN A., CRISTO T. G., SOUSA R. S., RAMOS E. A. S., KLASSEN G., 2018 - DNA Methylation status of the estrogen receptor α gene in canine mammary tumors. Veterinary Pathology 55(4), 510-516.
  5. BRONZINI I., ARESU L., PAGANIN M., MARCHIORETTO L., COMAZZI S., CIAN F., RIONDATO F., MARCONATO L., MARTINI V., TE KRONNIE G., 2017 - DNA methylation and targeted sequencing of methyltransferases family genes in canine acute myeloid leukaemia, modelling human myeloid leukaemia. Veterinary and Comparative Oncology 15(3), 910-918.
  6. BRYAN J. N., JABBES M., BERENT L. M., ARTHUR G. L., TAYLOR K. H., RISSETTO K. C., HENRY C. J., RAHMATPANAH F., RANKIN W. V., VILLAMIL J. A., LEWIS M. R., CALDWELL C. W., 2009 - Hypermethylation of the DLC1 CpG Island does not alter gene expression in canine lymphoma. BMC Genetics 10(1), 1-12.
  7. FINSTERER J., 2007 - Genetic, pathogenetic, and phenotypic implications of the mitochondrial A3243G tRNALeu (UUR) mutation. Acta Neurologica Scandinavica 116(1), 1-14.
  8. GOLDSCHMIDT M. H., PEÑA L., RASOTTO R., ZAPPULLI V., 2011 - Classification and grading of canine mammary tumors. Veterinary Pathology 48(1), 117-131.
  9. GRZYBOWSKA-SZATKOWSKA L., SLASKA B., 2012a - Mitochondrial DNA and carcinogenesis (Review). Molecular Medicine Reports 6(5), 923-930.
  10. GRZYBOWSKA-SZATKOWSKA L., SLASKA B., 2012b - Polymorphisms in genes encoding mttRNA in female breast cancer in Poland. Mitochondrial DNA 23(2), 106-111.
  11. KIM K. S., LEE S. E., JEONG H. W., HA J. H., 1998 - The complete nucleotide sequence of the domestic dog (Canis familiaris) mitochondrial genome. Molecular Phylogenetics and Evolution 10(2), 210-220.
  12. KOWAL K., ŚLASKA B., BOWNIK A., HORECKA B., GAWOR J., ŚMIECH A., TKACZYK A., 2019 - Analysis of mitochondrial genome from labrador (Canis lupus familiaris) with mammary gland tumour reveals novel mutations and polymorphisms. Annals of Animal Science 19(3), 619-632.
  13. KOWAL K., TKACZYK-WLIZŁO A., GAWOR J., ŚLASKA B., 2024 - Molecular differences in mitochondrial genomes (Mitogenomes) of dogs with recurrent and multiple tumours and their reference to the human mitochondrial genome. Annals of Animal Science 24(1), 89-97.
  14. KOWAL K., TKACZYK-WLIZŁO A., PIERZCHAŁA M., GAWOR J., ŚLASKA B., 2022 -Molecular differences in mitochondrial DNA Genomes of dogs with malignant mammary tumours. Veterinary and Comparative Oncology 20(1), 256-264.
  15. KOWAL K., TKACZYK-WLIZŁO A., PIERZCHAŁA M., ŚLASKA B., 2022 - Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene. Annals of Animal Science, 22(3), 915-922.
  16. KOWAL K., TKACZYK A., ZĄBEK T., PIERZCHAŁA M., ŚLASKA B., 2020 - Comparative analysis of CpG sites and islands distributed in mitochondrial DNA of model organisms. Animals 10(4), 665.
  17. KOZAKIEWICZ P., GRZYBOWSKA-SZATKOWSKA L., CIESIELKA M., RZYMOWSKA J., 2021 - The role of mitochondria in carcinogenesis. International Journal of Molecular Sciences 22(10), 5100.
  18. LARSSON N. G., 2010 - Somatic mitochondrial DNA mutations in mammalian aging. Annual Review of Biochemistry 79, 683-706.
  19. LI L. C., DAHIYA R., 2002 - MethPrimer: designing primers for methylation PCRs. Bioinformatics 18(11), 1427-1431.
  20. MONTANER-ANGOITI E., MARÍN-GARCÍA P. J., LLOBAT L., 2023 - Epigenetic alterations in canine malignant lymphoma: future and clinical outcomes. Animals 13(3), 468.
  21. MORIMOTO C. Y., TEDARDI M. V., DA FONSECA I. I. M., KIMURA K. C., SANCHES D. S., EPIPHANIO T. F., DE FRANCISCO STREFEZZI R., DAGLI M. L. Z., 2017 - Evaluation of the global DNA methylation in canine mast cell tumour samples by immunostaining of 5-methyl cytosine. Veterinary and Comparative Oncology 15(3).
  22. MORRIS J. S., 2016 - Genomic and proteomic profiling for cancer diagnosis in dogs. The Veterinary Journal 215, 101-109.
  23. NAM A. R., LEE K. H., HWANG H. J., SCHABORT J. J., AN J. H., WON S. H., CHO J. Y., 2020 - Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer. Clinical Epigenetics 12(1), 1-15.
  24. NOGUCHI S., MORI T., NAKAGAWA T., ITAMOTO K., HARAGUCHI T., MIZUNO T., 2015 - DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells. Melanoma Research, 25(5), 390-398.
  25. OKONECHNIKOV K., GOLOSOVA O., FURSOV M., VARLAMOV A., VASKIN Y., EFREMOV I., GREHOV O. G., KANDROV D., RASPUTIN K., SYABRO M., TLEUKENOV T., 2012 - Unipro UGENE: A unified bioinformatics toolkit. Bioinformatics 28(8), 1166-1167.
  26. SARVER A. L., MAKIELSKI K. M., DEPAUW T. A., SCHULTE A. J., MODIANO J. F., MODIANO C. F. J., 2022 - Increased risk of cancer in dogs and humans: a consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer 3(1), 3-19.
  27. SEMIK-GURGUL E., ZABEK T., FORNAL A., GURGUL A., PAWLINA-TYSZKO K., KLUKOWSKA-RÖTZLER J., BUGNO-PONIEWIERSKA M., 2018 - Analysis of the methylation status of CpG sites within cancer-related genes in equine sarcoids. Annals of Animal Science 18(4), 907-918.
  28. SLASKA B., GRZYBOWSKA-SZATKOWSKA L., NISZTuk s., surdyka m., rozanska d., 2015 -mitochondrial dna Polymorphism in Genes Encoding ND1, COI and CYTB in canine malignant cancers. Mitochondrial DNA 26(3), 452-458.
  29. SLASKA B., GRZYBOWSKA-SZATKOWSKA L., SURDYKA M., NISZTUK S., ROZANSKA D., ROZANSKI P., SMIECH A., ORZELSKI M., 2014 - Mitochondrial D-Loop mutations and polymorphisms are connected with canine malignant cancers. Mitochondrial DNA 25(3), 238-243.
  30. STEWART J. B., ALAEI-MAHABADI B., SABARINATHAN R., SAMUELSSON T., GORODKIN J., GUSTAFSSON C. M., LARSSON E., 2015 - Simultaneous DNA and RNA mapping of somatic mitochondrial mutations across diverse human cancers. PLOS Genetics 11(6), e1005333.
  31. SURDYKA M., SLASKA B., 2017a - Defect in ND2, COX2, ATP6 and COX3 Mitochondrial genes as a risk factor for canine mammary tumour. Veterinary and Comparative Oncology 15(3), 1062-1072.
  32. SURDYKA M., SLASKA B., 2017b - Defect of the mitochondrial DNA hypervariable region as a risk factor for canine mammary tumour. Veterinary and Comparative Oncology 15(3), 820-828.
  33. TKACZYK-WLIZŁO A., KOWAL K., ŚLASKA B., 2022 - Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: a review. Mitochondrion 63, 72-84.
  34. UNTERGASSER A., CUTCUTACHE I., KORESSAAR T., YE J., FAIRCLOTH B. C., REMM M., ROZEN S. G., 2012 - Primer3 - New capabilities and interfaces. Nucleic Acids Research 40(15), e115–e115.
  35. VAZQUEZ E., LIPOVKA Y., CERVANTES-ARIAS A., GARIBAY-ESCOBAR A., HABY M. M., QUEIROGA F. L., VELAZQUEZ C., 2023 - Canine mammary cancer: state of the art and future perspectives. Animals, 13(19), 3147.
  36. YUAN W., ZHANG R., LYU H., XIAO S., GUO D., ZHANG Q., ALI D. W., MICHALAK M., CHEN X. Z., ZHOU C., TANG J., 2024 - Dysregulation of tRNA methylation in cancer: mechanisms and targeting therapeutic strategies. Cell Death Discovery, 10(1), 1-19.
  37. ZIÓŁKOWSKA K., KOWAL K., TKACZYK-WLIZŁO A., ŚMIECH A., ŚLASKA B., 2023 -Mutations and polymorphisms in mitochondrial genome of dogs with solid mammary carcinoma – a preliminary study. Medycyna Weterynaryjna 79(11), 566-572.
Language: English
Page range: 225 - 234
Accepted on: Mar 17, 2025
Published on: Jul 3, 2025
Published by: Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Kaja Ziółkowska, Klaudia Lasota, Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Brygida Ślaska, published by Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.