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Mitochondrial DNA alternations in formalin-fixed paraffin-embedded tissue collected from dogs with malignant mammary gland tumours Cover

Mitochondrial DNA alternations in formalin-fixed paraffin-embedded tissue collected from dogs with malignant mammary gland tumours

Open Access
|Jul 2025

References

  1. ARENDT M.L., SAKTHIKUMAR S., MELIN M., ELVERS I., RIVERA P., LARSEN M., SAELLSTROM S., LINGAAS F., RONNBERG H., LINDBLAD-TOH K., 2023 - PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia. Scientific Reports 13(1), 632.
  2. BORGE K.S., BORRESEN-DALE A.L., LINGAAS F., 2011 - Identification of genetic variation in 11 candidate genes of canine mammary tumour. Veterinary and Comparative Oncology 9(4), 241-250.
  3. CASSALI G., JARK P., GAMBA C., DAMASCENO K., ESTRELA-LIMA A., NARDI A., FERREIRA E., HORTA R., FIRMO B., SUEIRO F., RODRIGUES L., NAKAGAKI K., 2020 -Consensus Regarding the Diagnosis, Prognosis and Treatment of Canine and Feline Mammary Tumors - 2019. Brazilian Journal of Veterinary Pathology 13(3), 555-574.
  4. COLLIVIGNARELLI F., TAMBURRO R., ASTE G., FALERNO I., DEL SIGNORE F., SIMEONI F., PATSIKAS M., GIANFELICI J., TERRAGNI R., ATTORRI V., CARLUCCIO A.,VIGNOLI M., 2021 - Lymphatic Drainage Mapping with Indirect Lymphography for Canine Mammary Tumors. Animals 11(1115), 1-9.
  5. COMBET C., BLANCHET C., GEOURJON C., DELÉAGE G., 2000 - NPS@: network protein sequence analysis. Trends in biochemical sciences 3, 147-150.
  6. DA SILVA E.M.G., DOS SANTOS T.R., SILVA M.J.B., 2023 - Identifying the Risk Factors for Malignant Mammary Tumors in Dogs: A Retrospective Study. Veterinary Sciences 10(10).
  7. DEN DUNNEN J.T., DALGLEISH R., MAGLOTT D.R., HART R.K., GREENBLATT M.S., MCGOWAN-JORDAN J., ROUX A.F., SMITH T., ANTONARAKIS S.E., TASCHNER P.E., 2016 -HGVS Recommendations for the Description of Sequence Variants: 2016 Update. Human Mutation 37(6), 564-569.
  8. DI GIACOMO D., DI DOMENICO M., DEFOURNY S.V.P., MALATESTA D., DI TEODORO G., MARTINO M., VIOLA A., D’ALTERIO N., CAMMA C., MODESTO P., PETRINI A., 2022 - Validation of AmpliSeq NGS Panel for BRCA1 and BRCA2 Variant Detection in Canine Formalin-Fixed Paraffin-Embedded Mammary Tumors. Life 12(6).
  9. DOLKA I., KROL M., SAPIERZYNSKI R., 2016 - Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study. Research in Veterinary Science 105, 124-133.
  10. ENGINLER S.O., AKIS I., TOYDEMIR T.S., OZTABAK K., HAKTANIR D., GUNDUZ M.C., KIRSAN I., FIRAT I., 2014 - Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours. Veterinary Research Communications 38(1), 21-27.
  11. GASTEIGER E., GATTIKER A., HOOGLAND C., IVANYI I., APPEL R.D.,BAIROCH A., 2003 - ExPASy: The proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Research 31(13), 3784-3788.
  12. GOLDSCHMIDT M., PENA L., RASOTTO R.,ZAPPULLI V., 2011 - Classification and grading of canine mammary tumors. Veterinary pathology 48(1), 117-131.
  13. KASZAK I., WITKOWSKA-PILASZEWICZ O., DOMRAZEK K., JURKA P., 2022 - The Novel Diagnostic Techniques and Biomarkers of Canine Mammary Tumors. Veterinary Sciences 9(10).
  14. KIM K.S., LEE S.E., JEONG H.W., HA J.H., 1998 - The Complete Nucleotide Sequence of the Domestic Dog (Canis familiaris) Mitochondrial Genome. Moleular Phylogenetics and Evolution 10(2), 210-220.
  15. KOWAL K., TKACZYK-WLIZLO A., PIERZCHALA M., GAWOR J., SLASKA B., 2022 -Molecular differences in mitochondrial DNA genomes of dogs with malignant mammary tumours. Veterinary and Comparative Oncology 20(1), 256-264.
  16. KOWAL K., TKACZYK-WLIZŁO A., GAWOR J., ŚLASKA B., 2023 - Molecular differences in mitochondrial genomes (mitogenomes) of dogs with recurrent and multiple tumours and their reference to the human mitochondrial genome. Annals of Animal Science 0(0).
  17. KOZAKIEWICZ P., GRZYBOWSKA-SZATKOWSKA L., CIESIELKA M., RZYMOWSKA J., 2021 - The Role of Mitochondria in Carcinogenesis. International Journal of Molecular Sciences 22(10).
  18. MISDORP W., ELSE R.W., HELLMEN E., LIPSCOM T.P., (1999) World Health Organization International Histologic Classification of Tumours of Domestic Animals. Shulman F.O. (ed), pp. 16-29, Armed Forces Institute of Pathology, Washington, USA.
  19. MUSCATELLO L.V., PAPA V., MILLANTA F., SARLI G., BACCI B., CENACCHI G., POLI A., GIUDICE C., BRUNETTI B., 2021 - Canine Mammary Carcinoma With Vacuolated Cytoplasm: Glycogen-Rich Carcinoma, a Histological Type Distinct From Lipid-Rich Carcinoma. Veterinary Pathology 58(1), 63-70.
  20. OKONECHNIKOV K., GOLOSOVA O., FURSOV M., TEAM U., 2012 - Unipro UGENE: a unified bioinformatics toolkit. Bioinformatics 28(8), 1166-1167.
  21. PATEL M.P., GHODASARA D.J., RAVAL S.H., JOSHI B.P., 2019 - Incidence, Gross Morphology, Histopathology and Immunohistochemistry of Canine Mammary Tumors. Journal of Veterinary Sciences & Biotechnology 14(4), 40-44.
  22. RUEDA J.R., PORTO C.D., FRANCO R.P., DA COSTA I.B., BUENO L.M.C., GIRIO R.J.S., MANHOSO F.F.R., BUENO P., REPETTI C.S.F., 2024 - Mammary neoplasms in female dogs: Clinical, diagnostic and therapeutic aspects. Veterinarni Medicina 69(4), 99-114.
  23. SCHULMAN F.Y., GOLDSCHMIDT M.H., HARDCASTLE M., ZAPPULLI V.E.G., 2022 - Teat sinus and duct adenomatous hyperplasia in dogs. Veterinary Pathology 59(2), 256-263.
  24. SLASKA B., GRZYBOWSKA-SZATKOWSKA L., BUGNO-PONIEWIERSKA M., GURGUL A., SMIECH A., ROZANSKA D., DUDKA J., 2016 - Relevance of Molecular Changes in the ND4 Gene in German Shepherd Dog Tumours. Polish Journal of Veterinary Sciences 19(3), 461-469.
  25. SURDYKA M.,SLASKA B. 2017 - Defect in ND2, COX2, ATP6 and COX3 mitochondrial genes as a risk factor for canine mammary tumour. Veterinary and Comparative Oncology 15(3), 1062-1072.
  26. TKACZYK-WLIZLO A., KOWAL K., SLASKA B., 2022 - Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review. Mitochondrion 63, 72-84.
  27. TKACZYK-WLIZLO A., KOWAL K., SMIECH A., SLASKA B., 2024 - Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review. Journal of Applied Genetics 65(1), 137-153.
  28. UNTERGASSER A., CUTCUTACHE I., KORESSAAR T., YE J., FAIRCLOTH B.C., REMM M., ROZEN S.G., 2012 - Primer3--new capabilities and interfaces. Nucleic acids research 40(15), e115.
  29. ZAPPULLI V., PENA L., RASOTTO R., GOLDSCHMIDT M., GAMA A., SCRUGGS J., KIUPEL M., 2019 - Surgical Pathology of Tumors of Domestic Animals Volume 2: Mammary Tumors, Davis-Thompson Foundation, Gurnee, Illinois.
Language: English
Page range: 215 - 224
Accepted on: Mar 17, 2025
Published on: Jul 3, 2025
Published by: Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:

© 2025 Angelika Tkaczyk-Wlizło, Krzysztof Kowal, Kaja Ziółkowska, Paweł Grychnik, Anna Śmiech, Katarzyna Kępka-Borkowska, Mariusz Pierzchała, Brygida Ślaska, published by Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.