Ophthalmic Changes in Astronauts: A Current Understanding

Cogswell, Finn

doi:10.2478/asam-2024-0004

Abstract

This paper provides a brief review of the literature on ophthalmic abnormalities commonly experienced by astronauts, and introduces issues that they present for future spaceflight. Together known as the Spaceflight-Associated Neuro-Ocular Syndrome (SANS), these changes in ocular structure and visual function have been widely reported in astronauts both during and following long-duration spaceflights. With several such spaceflights planned for the near future, extensive research is taking place to further understand the aetiologies of SANS so that ophthalmic complications in astronauts may be mitigated.

References

Marshall-Bowman, K., Barratt, M. R., & Gibson, C. R. Ophthalmic changes and increased intracranial pressure associated with long duration spaceflight: An emerging understanding. Acta Astronautica 87, 77-87.
Search in Google Scholar Back to article
Mader, T.H., Gibson, C.R., Pass, A.F., Kramer, L.A., Lee, A.G., Fogarty, J., Tarver, W. J., Dervay, J. P., Hamilton, D. R., Sargsyan, A., Phillips, J. L., Tran, D., Lipsky, W., Choi, J., Stern, C., Kuyumjian, R., Polk, J. D. Optic disc edema, globe fattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology 118, 2058–69.
Search in Google Scholar Back to article
Taibbi, G., Cromwell, R. L., Kapoor, K. G., Godley, B. F., & Vizzeri, G. The Effect of Microgravity on Ocular Structures and Visual Function: A Review. Survey of Ophthalmology 58(2), 155-163.
Search in Google Scholar Back to article
Zhang, L., & Hargens, A. R. Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures. Physiol Rev 98, 59–87.
Search in Google Scholar Back to article
Fogarty, J.A., Otto, C., Kerstman, E., Oubre, C., & Wu, J. The Visual Impairment Intracranial Pressure Summit Report. Hanover, MD: NASA Center for AeroSpace Information.
Search in Google Scholar Back to article
Lee, A. G., Tarver, W. J., Mader, T. H., Gibson, C. R., Hart, S. F., & Otto, C. A. Neuro-ophthalmology of space flight. J. Neuroophthalmol 36, 85-91.
Search in Google Scholar Back to article
Mader, T. H., Gibson, C. R., Otto, C. A., Sargsyan, A. E., Miller, N. R., Subramanian, P. S., Hart, S. F., Lipsky, W., Patel, N. B., & Lee, A. G. Persistent asymmetric optic disc swelling after long-duration space flight: implications for pathogenesis. J. Neuroophthalmol 37, 133-139.
Search in Google Scholar Back to article
Mader, T. H., Gibson, C. R., Pass, A. F., Lee, A. G., Killer, H. E., Hansen, H. C., Dervay, J. P., Barrat, M. R., Tarver, W. J., Sargsyan, A. E., Kramer, L. A., Riascos, R., Bedi, D. G., & Pettit, D. R. Optic disc edema in an astronaut after repeat long-duration space flight. J. Neuroophthalmol 33, 249-255.
Search in Google Scholar Back to article
Zwart, S. R., Gibson, C. R., Gregory, J. F., Mader, T. H., Stover, P. J., Zeisel, S. H., & Smith, S. M. Astronaut ophthalmic syndrome. Federation of American Societies for Experimental Biology Journal 31(9). Published Online: 25 May 2017.
Search in Google Scholar Back to article
Zwart, S. R., Gibson, C. R., Mader, T. H., Ericson, K., Ploutz-Snyder, R., Heer, M., Smith, S. M. Vision Changes after Spaceflight Are Related to Alterations in Folate– and Vitamin B-12–Dependent One-Carbon Metabolism. The Journal of Nutrition 142(3), 427–431.
Search in Google Scholar Back to article

Ophthalmic Changes in Astronauts: A Current Understanding

Abstract

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