Abstract
Background: Multidrug-resistant tuberculosis (MDR-TB) continues to be a global health catastrophe. This prospective study examines the subjective impact of the disease as experienced by patients using the Saint George’s Respiratory Questionnaire. Methodology: The study involved 244 patients diagnosed with drug-sensitive and drug-resistant pulmonary tuberculosis over a 10-year years. These patients were administered the Saint George’s Respiratory Questionnaire, which was evaluated in comparison between the two groups to determine the progressive impact of disease in patients with MDR-TB compared to patients with drug-sensitive tuberculosis (DS-TB). Results: The analysis showed that patients with MDR-TB had statistically significantly higher symptomatic activity and impact scores compared to patients with drug-sensitive tuberculosis. Conclusions: The results suggest that patients diagnosed with MDR-TB at different stages of disease progression need urgent attention from healthcare providers.