Campylobacter jejuni: a Comprehensive Review of a Leading Foodborne Zoonotic Pathogen
References
- Omole, Z., Dorrell, N., Elmi, A., Nasher, F., Gundogdu, O., & Wren, B. W. (2024). Pathogenicity and virulence of Campylobacter jejuni: What do we really know? Virulence, 15 (1), 2436060, http://dx.doi.org/10.1080/21505594.2024.2436060
- Badjo, AO.R., Kabore, N.F., Zongo, A., Gnada, K., Ouattara, A., Muhigwa, M., et al. (2024). Burden and epidemiology of Campylobacter species in acute enteritis cases in Burkina Faso. BMC Infectious Diseases, 24 (1), 808, http://dx.doi.org/10.1186/s12879-024-09708-5
- Islam, S.S., Hoque, N., Akhter, A.T., Castellan, D.M., Samosornsuk, S., Samosornsuk, W., et al. (2023). Burden of campylobacteriosis in Bangladesh: Challenges and opportunities. Asian Journal of Medical and Biological Research, 9 (2), 38–50, http://dx.doi.org/10.3329/ajmbr.v9i2.67141
- Geladari, EV., Kounatidis, D., Margellou, E., Evangelopoulos, A., Jahaj, E., Adamou, A., et al. (2025). The growing antibiotic resistance of Campylobacter species: Is there any link with climate change? Microbiological Research, 16 (11), 226, http://dx.doi.org/10.3390/microbiolres16110226
- Liu, F., Lee, S.A., Xue, J., Riordan, S.M., & Zhang, L. (2022). Global epidemiology of campylobacteriosis and the impact of COVID-19. Frontiers in Cellular and Infection Microbiology, 12, 979055, http://dx.doi.org/10.3389/fcimb.2022.979055
- Garbern, S.C., Chu, T.C., Gainey, M., Kanekar, S.S., Nasrin, S., Qu, K., et al. (2021). Multidrug-resistant enteric pathogens in older children and adults with diarrhea in Bangladesh: Epidemiology and risk factors. Tropical Medicine and Health, 49 (1), 34, http://dx.doi.org/10.1186/s41182-021-00320-1
- Rahman, M.A., Paul, P.R., Hoque, N., Islam, S.S., Haque, A.K.M.Z., Sikder, M.H., et al. (2021). Prevalence and antimicrobial resistance of Campylobacter species in diarrheal patients in Mymensingh, Bangladesh. BioMed Research International, 2021, 9229485, http://dx.doi.org/10.1155/2021/9229485
- Varrone, L., Glass, K., Stafford, R.J., Kirk, M.D., & Selvey, L. (2020). A meta-analysis of case-control studies examining sporadic campylobacteriosis in Australia and New Zealand from 1990 to 2016. Australian and New Zealand Journal of Public Health, 44 (4), 313–319, http://dx.doi.org/10.1111/1753-6405.13006
- Mir, F., Dar, W., Yaqoob, A., Wani, M., Asmi, R., & Wani, M. (2023). Seroprevalence of Campylobacter jejuni infection in common subtypes of Guillain–Barré syndrome in Kashmiri population. Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 59 (1), 180, http://dx.doi.org/10.1186/s41983-023-00733-2
- Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., et al. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71, http://dx.doi.org/10.1136/bmj.n71
- Frirdich, E., Vermeulen, J., Biboy, J., Vollmer, W., & Gaynor, E.C. (2023). Multiple Campylobacter jejuni proteins affecting the peptidoglycan structure and the degree of helical cell curvature. Frontiers in Microbiology, 14, 1162806, http://dx.doi.org/10.3389/fmicb.2023.1162806
- Choi, Y., Park, J.S., Kim, J., Min, K., Mahasenan, K., Kim, C., et al. (2022). Structure-based inhibitor design for reshaping bacterial morphology. Communications Biology, 5 (1), 395, http://dx.doi.org/10.1038/s42003-022-03374-3
- Nennig, M., Clément, A., Longueval, E., Bernardi, T., Ragimbeau, C., & Tresse, O. (2022). Metaphenotypes associated with recurrent genomic lineages of Campylobacter jejuni responsible for human infections in Luxembourg. Frontiers in Microbiology, 13, 901192, http://dx.doi.org/10.3389/fmicb.2022.901192
- Dessalegn, B., Debelo, M., Hess, M., & Awad, W.A. (2025). Gut microbiota—Campylobacter jejuni crosstalk in broiler chickens: A comprehensive review. Poultry, 4 (4), http://dx.doi.org/10.3390/poultry4040044
- Yan, W., Zhou, Q., Yuan, Z., Fu, L., Wen, C., Yang, N., et al. (2021). Impact of the gut microecology on Campylobacter presence revealed by comparisons of the gut microbiota from chickens raised on litter or in individual cages. BMC Microbiology, 21 (1), 290, http://dx.doi.org/10.1186/s12866-021-02353-5
- Shayya, N.W., Foote, M.S., Langfeld, L.Q., Du, K., Bandick, R., Mousavi, S., Bereswill, S., et al. (2023). Human microbiota associated IL-10-/- mice: A valuable enterocolitis model to dissect the interactions of Campylobacter jejuni with host immunity and gut microbiota. European Journal of Microbiology & Immunology, 12 (4), 107–122, http://dx.doi.org/10.1556/1886.2022.00024
- Heimesaat, M., Genger, C., Kløve, S., Weschka, D., Mousavi, S., & Bereswill, S. (2020). The host-specific intestinal microbiota composition impacts infection in a clinical mouse model of campylobacteriosis. Pathogens, 9, http://dx.doi.org/10.3390/pathogens9100804
- Mekonnen, Y.T., Savini, F., Indio, V., Seguino, A., Giacometti, F., Serraino, A., et al. (2024). Systematic review on microbiome-related nutritional interventions interfering with the colonization of foodborne pathogens in broiler gut to prevent contamination of poultry meat. Poultry Science, 103 (5), 103607, http://dx.doi.org/10.1016/j.psj.2024.103607
- Bretto, E., Urpì-Ferreruela, M., Casanova, G.R., & González-Suárez, B. (2025). The role of gut microbiota in gastrointestinal immune homeostasis and inflammation: Implications for inflammatory bowel disease. Biomedicines, 13 (8), http://dx.doi.org/10.3390/biomedicines13081807
- Lopes, G.V., Ramires, T., Kleinubing, N.R., Scheik, L.K., Fiorentini, Â.M., & Padilha da Silva, W. (2021). Virulence factors of foodborne pathogen Campylobacter jejuni. Microbial Pathogenesis, 161 (Pt A), 105265, http://dx.doi.org/10.1016/j.micpath.2021.105265
- Dermatas, A., Rozos, G., Voidarou, C., Akrida-Demertzi, K., & Demertzis, P. (2023). Biodiversity dynamics of Campylobacter species in chicken tissues in rural households in region Epirus, Greece. Applied Sciences, 13(10), 6073, http://dx.doi.org/10.3390/app13106073
- European Centre for Disease Prevention and Control. (2024). Campylobacteriosis: Annual epidemiological report for 2022. http://dx.doi.org/10.2900/xxxx
- Shiferaw, J., Megersa, B., Zewge, F., Haaland, S., & Eregno, F.E. (2025). A One Health perspective on the prevalence and antimicrobial resistance of Campylobacter in Ethiopia: A systematic review and meta-analysis. The Microbe, 9, 100633, http://dx.doi.org/10.1016/j.microb.2025.100633
- Mughini-Gras, L., Pijnacker, R., Coipan, C., Mulder, A.C., Fernandes Veludo, A., et al. (2021). Sources and transmission routes of campylobacteriosis: A combined analysis of genome and exposure data. Journal of Infection, 82(2), 216–226, http://dx.doi.org/10.1016/j.jinf.2020.11.012
- Popa, S.A., Herman, V., Tîrziu, E., Morar, A., Ban-Cucerzan, A., Imre, M., et al. (2025). Public health risk of Campylobacter spp. isolated from slaughterhouse and retail poultry meat: Prevalence and antimicrobial resistance profiles. Pathogens, 14(4), 316, http://dx.doi.org/10.3390/pathogens14040316
- Gourmelon, M., Boukerb, A.M., Nabi, N., Banerji, S., Joensen, K.G., Serghine, J., et al. (2022). Genomic diversity of Campylobacter lari group isolates from Europe and Australia in a One Health context. Applied and Environmental Microbiology, 88(23), e01368-22, http://dx.doi.org/10.1128/aem.01368-22
- Admasie, A., Wei, X., Johnson, B., Burns, L., Pawar, P., Aurand-Cravens, A., et al. (2024). Genomic diversity of Campylobacter jejuni and Campylobacter coli isolated from the Ethiopian dairy supply chain. PLoS ONE, 19(8), e0305581, http://dx.doi.org/10.1371/journal.pone.0305581
- Quino, W., Caro-Castro, J., Mestanza, O., Hurtado, V., Zamudio, M.L., Cruz-Gonzales, G., et al. (2022). Emergence and molecular epidemiology of Campylobacter jejuni ST-2993 associated with a large outbreak of Guillain–Barré syndrome in Peru. Microbiology Spectrum, 10(5), e01187-22, http://dx.doi.org/10.1128/spectrum.01187-22
- Alland, J.K., Pascoe, B., Bayliss, S.C., Mourkas, E., Berthenet, E., Thorpe, H.A., et al. (2021). Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages. PLoS Genetics, 17(9), e1009829, http://dx.doi.org/10.1371/journal.pgen.1009829
- Mourkas, E., Taylor, A.J., Méric, G., Bayliss, S.C., Pascoe, B., Mageiros, L., et al. (2020). Agricultural intensification and the evolution of host specialism in the enteric pathogen Campylobacter jejuni. Proceedings of the National Academy of Sciences of the United States of America, 117(20), 11018–11028, http://dx.doi.org/10.1073/pnas.1917168117
- Tikhomirova, A., McNabb, E.R., Petterlin, L., Bellamy, G.L., Lin, K.H., Santoso, C.A., et al. (2024). Campylobacter jejuni virulence factors: Update on emerging issues and trends. Journal of Biomedical Science, 31(1), 45, http://dx.doi.org/10.1186/s12929-024-00964-5
- Reuter, M., Ultee, E., Toseafa, Y., Tan, A., & van Vliet, A.H.M. (2020). Inactivation of the core cheVAWY chemotaxis genes disrupts chemotactic motility and organised biofilm formation in Campylobacter jejuni. FEMS Microbiology Letters, 367(24), fnaa198, http://dx.doi.org/10.1093/femsle/fnaa198
- Liu, X., & Ottemann, K.M. (2022). Methylation-independent chemotaxis systems are the norm for gastric-colonizing Helicobacter species. Journal of Bacteriology, 204(9), e00231-22, http://dx.doi.org/10.1128/jb.00231-22
- Elmi, A., Nasher, F., Dorrell, N., Wren, B., & Gundogdu, O. (2021). Revisiting Campylobacter jejuni virulence and fitness factors: Role in sensing, adapting, and competing. Frontiers in Cellular and Infection Microbiology, 10, 607704, http://dx.doi.org/10.3389/fcimb.2020.607704
- Gahamanyi, N., Song, D.G., Mboera, L.E.G., Matee, M.I., Mutangana, D., Amachawadi, R.G., et al. (2022). Insights into the virulence of Campylobacter jejuni associated with two-component signal transduction systems and single regulators. Microbiological Research, 13(2), 188–200, http://dx.doi.org/10.3390/microbiolres13020015
- McDonald, J.B., Scott, N.E., Underwood, G.J., Andrews, D.M., Van, T.T.H., & Moore, R.J. (2023). Characterisation of N-linked protein glycosylation in the bacterial pathogen Campylobacter hepaticus. Scientific Reports, 13(1), 227, http://dx.doi.org/10.1038/s41598-022-26967-5
- Nothaft, H., Bian, X., Shajahan, A., Miller, W.G., Bolick, D.T., Guerrant, R.L., et al. (2021). Detecting glucose fluctuations in the Campylobacter jejuni N-glycan structure. ACS Chemical Biology, 16(11), 2690–2701, http://dx.doi.org/10.1021/acschembio.1c00669
- Hadjineophytou, C., Anonsen, J.H., Svingerud, T., Mortimer, T.D., Grad, Y.H., Scott, N.E., et al. (2022). Sculpting the bacterial O-glycoproteome: Functional analyses of orthologous oligosaccharyltransferases with diverse targeting specificities. mBio, 13(3), e03797-21, http://dx.doi.org/10.1128/mbio.03797-21
- Karlic, K.I., Tahir, H., & Scott, N.E. (2025). Glycoproteomics and its role in understanding bacterial O-linked glycosylation. Proteomics, 25(21–22), 160–176, http://dx.doi.org/10.1002/pmic.202400160
- Kreling, V., Falcone, F.H., Kehrenberg, C., & Hensel, A. (2020). Campylobacter sp.: Pathogenicity factors and prevention methods—New molecular targets for innovative antivirulence drugs? Applied Microbiology and Biotechnology, 104(24), 10409–10436, http://dx.doi.org/10.1007/s00253-020-10948-1
- Shayya, N.W., Bandick, R., Busmann, L.V., Mousavi, S., Bereswill, S., & Heimesaat, M.M. (2023). Metabolomic signatures of intestinal colonization resistance against Campylobacter jejuni in mice. Frontiers in Microbiology, 14, 1331114, http://dx.doi.org/10.3389/fmicb.2023.1331114
- Yeow, M., Liu, F., Ma, R., Williams, T.J., Riordan, S.M., & Zhang, L. (2020). Analyses of energy metabolism and stress defence provide insights into Campylobacter concisus growth and pathogenicity. Gut Pathogens, 12, 13, http://dx.doi.org/10.1186/s13099-020-00348-0
- Garber, J.M., Nothaft, H., Pluvinage, B., Stahl, M., Bian, X., Porfirio, S., et al. (2020). The gastrointestinal pathogen Campylobacter jejuni metabolizes sugars with potential help from commensal Bacteroides vulgatus. Communications Biology, 3(1), 2, http://dx.doi.org/10.1038/s42003-019-0731-5
- Callahan, S.M., Dolislager, C.G., & Johnson, J.G. (2021). The host cellular immune response to infection by Campylobacter spp. and its role in disease. Infection and Immunity, 89(8), e00116-21, http://dx.doi.org/10.1128/IAI.00116-21
- Fu, Y., Alenezi, T., Almansour, A., Wang, H., Jia, Z., & Sun, X. (2021). The role of immune response and microbiota on campylobacteriosis. IntechOpen, http://dx.doi.org/10.5772/intechopen.97386
- Roa-Bautista, A., Brown, L.K., Tadros, S., Burns, S.O., Godbole, G., & Lowe, D.M. (2023). Clinical features, immunological characteristics, and treatment outcomes of Campylobacter spp. infections in patients with common variable immunodeficiency. Journal of Allergy and Clinical Immunology: In Practice, 11(11), 3493–3501.e4, http://dx.doi.org/10.1016/j.jaip.2023.08.022
- Elgamoudi, B.A., & Korolik, V. (2021). Campylobacter biofilms: Potential of natural compounds to disrupt Campylobacter jejuni transmission. International Journal of Molecular Sciences, 22(22), 12159, http://dx.doi.org/10.3390/ijms222212159
- Zhong, X., Wu, Q., Zhang, J., Ma, Z., Wang, J., Nie, X., et al. (2020). Campylobacter jejuni biofilm formation under aerobic conditions and inhibition by ZnO nanoparticles. Frontiers in Microbiology, 11, 207, http://dx.doi.org/10.3389/fmicb.2020.00207
- Enany, S., Piccirillo, A., Elhadidy, M., & Tryjanowski, P. (2021). Editorial: The role of environmental reservoirs in Campylobacter-mediated infection. Frontiers in Cellular and Infection Microbiology, 11, 773436, http://dx.doi.org/10.3389/fcimb.2021.773436
- Ocejo, M., Oporto, B., Lavín, J.L., & Hurtado, A. (2021). Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants. Scientific Reports, 11(1), 8998, http://dx.doi.org/10.1038/s41598-021-88527-5
- Hlshwayo, D.F., Sigaúque, B., & Bila, C.G. (2020). Epidemiology and antimicrobial resistance of Campylobacter spp. in animals in Sub-Saharan Africa: A systematic review. Heliyon, 6(3), e03537, http://dx.doi.org/10.1016/j.heliyon.2020.e03537
- Elhadidy, M., Ali, M.M., El-Shibiny, A., Miller, W.G., Elkhatib, W.F., Botteldoorn, N., et al. (2020). Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases. PLoS ONE, 15(1), e0227833, http://dx.doi.org/10.1371/journal.pone.0227833
- Zhang, Q., Beyi, A.F., & Yin, Y. (2023). Zoonotic and antibiotic-resistant Campylobacter: A view through the One Health lens. One Health Advances, 1(1), 4, http://dx.doi.org/10.1186/s44280-023-00004-5
- Yagi, S., Okada, A., & Inoshima, Y. (2022). Role of temperature, nutrition, oxygen, osmolality, and bacterial strain in inducing a viable but non-culturable state in Campylobacter jejuni. Journal of Microbiological Methods, 195, 106456, http://dx.doi.org/10.1016/j.mimet.2022.106456
- Neyaz, L.A., Arafa, S.H., Alsulami, F.S., Ashi, H., Elbanna, K., & Abulreesh, H.H. (2024). Culture-based standard methods for the isolation of Campylobacter spp. in food and water. Polish Journal of Microbiology, 73(4), 433–454, http://dx.doi.org/10.33073/pjm-2024-045
- Balta, I., Marcu, A., Linton, M., Kelly, C., Gundogdu, O., Stef, L., et al. (2021). Mixtures of natural antimicrobials can reduce Campylobacter jejuni, Salmonella enterica and Clostridium perfringens infections and cellular inflammatory response in MDCK cells. Gut Pathogens, 13(1), 37, http://dx.doi.org/10.1186/s13099-021-00436-7
- Zhang, T., Nickerson, R., Zhang, W., Peng, X., Shang, Y., Zhou, Y., et al. (2024). The impacts of animal agriculture on One Health—Bacterial zoonosis, antimicrobial resistance, and beyond. One Health, 18, 100748, http://dx.doi.org/10.1016/j.onehlt.2024.100748
- Gottapu, C., Edison, L.K., Butcher, G.D., & Kariyawasam, S. (2025). Preharvest control of Campylobacter colonization in chickens, with a special emphasis on vaccination strategies. Microorganisms, 13(10), 2378, http://dx.doi.org/10.3390/microorganisms13102378
- Huang, H., & Garcia, M.M. (2022). Isolation and identification of Campylobacter spp. from food and food-related environment. IntechOpen, http://dx.doi.org/10.5772/intechopen.102345
- Elbehiry, A., & Marzouk, E. (2025). From farm to fork: Antimicrobial-resistant bacterial pathogens in livestock production and the food chain. Veterinary Sciences, 12(9), 862, http://dx.doi.org/10.3390/vetsci12090862
- Abebe, E., Gugsa, G., & Ahmed, M. (2020). Review on major food-borne zoonotic bacterial pathogens. Journal of Tropical Medicine, 2020, 4674235, http://dx.doi.org/10.1155/2020/4674235
- Bai, Y., Lin, X.H., Zhu, J.H., Cui, S.H., Guo, L.X., Yan, S.F., Wang, W., Xu, J., & Li, F.Q. (2021). Quantification of cross-contamination of Campylobacter jejuni during food preparation in a model kitchen in China. Journal of Food Protection, 84(5), 850–856, http://dx.doi.org/10.4315/JFP-20-280
- Campylobacter jejuni infection. (2025). Campylobacter jejuni infection. Retrieved March 30, 2026, from https://www.hopkinsmedicine.org/health/conditions-and-diseases/campylobacter-jejuni
- Public Health Agency of Canada. (2012). Campylobacter jejuni. Retrieved March 30, 2026, from https://www.canada.ca/en/public-health/services/food-poisoning/campylobacter-jejuni.html
- Taha-Abdelaziz, K., Singh, M., Sharif, S., Sharma, S., Kulkarni, R.R., Alizadeh, M., Yitbarek, A., & Helmy, Y.A. (2023). Intervention strategies to control Campylobacter at different stages of the food chain. Microorganisms, 11(1), 113, http://dx.doi.org/10.3390/microorganisms11010113
- Royden, A., Christley, R., Prendiville, A., & Williams, N.J. (2021). The role of biosecurity in the control of Campylobacter: A qualitative study of the attitudes and perceptions of UK broiler farm workers. Frontiers in Veterinary Science, 8,http://dx.doi.org/10.3389/fvets.2021.751699
- Hakeem, W.G.A., Fathima, S., Shanmugasundaram, R., & Selvaraj, R.K. (2022). Campylobacter jejuni in poultry: Pathogenesis and control strategies. Microorganisms, 10(11), http://dx.doi.org/10.3390/microorganisms10112134
- European Food Safety Authority & European Centre for Disease Prevention and Control. (2024). The European Union One Health 2024 zoonosis report. EFSA Journal, 22(12), e08934, http://dx.doi.org/10.2903/j.efsa.2024.8934
- Al-Neama, R.T., Bown, K.J., Blake, D.P., & Birtles, R.J. (2021). Determinants of Eimeria and Campylobacter infection dynamics in UK domestic sheep: The role of co-infection. Parasitology, 148(5), 623–629, http://dx.doi.org/10.1017/S0031182020002194
- Sinha, R., LeVeque, R.M., Callahan, S.M., Chatterjee, S., Stopnisek, N., Kuipel, M., et al. (2024). Gut metabolite L-lactate supports Campylobacter jejuni population expansion during acute infection. Proceedings of the National Academy of Sciences of the United States of America, 121(2), e2316540120, http://dx.doi.org/10.1073/pnas.2316540120
- Zeznitzeck, J., Breves, G., Rychlik, I., Hoerr, F.J., von Altrock, A., Rath, A., & Rautenschlein, S. (2022). The effect of Campylobacter jejuni and Campylobacter coli colonization on the gut morphology, functional integrity, and microbiota composition of female turkeys. Gut Pathogens, 14(1), 33, http://dx.doi.org/10.1186/s13099-022-00494-7
- Linn, K.Z., Furuta, M., Nakayama, M., Masuda, Y., Honjoh, K.I., & Miyamoto, T. (2021). Characterization and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from chicken and pork. International Journal of Food Microbiology, 360, 109440, http://dx.doi.org/10.1016/j.ijfoodmicro.2021.109440
DOI: https://doi.org/10.2478/arls-2026-0009 | Journal eISSN: 2543-8050
Language: English
Page range: 32 - 45
Submitted on: Mar 1, 2025
Accepted on: Apr 1, 2026
Published on: Apr 10, 2026
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© 2026 Proteek Bhattacharjee, Halima-E-Sadia, Tamanna Zerin, published by University of Life Sciences “King Mihai I“ from Timisoara
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