| Misleading Reporting | Fau V et al.13 | Orthod Fr. | 2017 | Adverse Effect not mentioned |
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| Darwiche F et al.14 | J Contemp Dent Pract. | 2020 | There is limited available evidence about effectiveness of corticotomy assisted accelerated orthodontics. Although the current review indicates that the corticotomy assisted accelerated orthodontic treatment method can fasten the treatment duration by 2.2–3 folds compared to conventional orthodontic treatment. |
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| Elmotaleb M et al.15 | J Int Soc Prev Community Dent. | 2019 | Adverse Effect not mentioned |
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| Figueiredo D et al.16 | J Clin Exp Dent. | 2019 | Study limitations not mentioned |
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| Li Z et al.17 | Angle Orthod. | 2021 | Study limitations not mentioned |
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| Camacho A et al.18 | Photobiomodul Photomed Laser Surg. | 2020 | Adverse Effect not mentioned |
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| Bakdach W et al. 19 | Dent Med Probl. | 2020 | Low level laser therapy can speed up the rate of tooth movement. However, the overall quality of evidence ranged from low to very low and the clinical significance of the obtained statistically significant differences is questionable. |
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| Imani M et al.20 | Acta Inform Med. | 2018 | Adverse Effect not mentioned |
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| Jedlinski M et al.21 | Photobiomodul Photomed Laser Surg. | 2020 | Adverse Effect not mentioned |
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| Keerthana P et al.22 | J Oral Biol Craniofac Res. | 2020 | Study limitations not mentioned |
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| Kalemaj Z et al.23 | Eur J Oral Implantol. | 2015 | There is some evidence that LLLT can slightly accelerate OTM but this result is not significant and the effect estimated is not clinically relevant. |
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| Sousa M et al.24 | Photomed Laser Surg. | 2014 | LLL seems to have a demonstrated efficacy, but further studies are warranted to determine the best protocols with regard to energy and frequency. |
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| Mohaghegh S et al.25 | Int Orthod. | 2021 | Adverse Effect not mentioned |
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| Li J et al.26 | Photobiomodul Photomed Laser Surg. | 2021 | Adverse Effect not mentioned |
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| Ge M et al.27 | Lasers Med Sci. | 2015 | Adverse Effect not mentioned |
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| Mheissen S.28 | PLOS ONE | 2020 | Low quality evidence suggests that piezocision is an effective surgical procedure in accelerating the rate of canine retraction in the first two months and reducing the treatment duration.However, this effect appears to be clinically insignificant. |
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| Alfawal A et al.29 | Progress in Orthodontics | 2016 | There is limited available evidence about the effectiveness of minimally invasive surgically accelerated orthodontics (MISAO). Although the current review indicated that MISAO can help in accelerating canine retraction. |
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| Al- Shahrani I et al.30 | Complementary Therapies in Medicine | 2019 | Findings of the current systematic review suggest a possible benefit with photobiomodulation therapy and tooth movement in orthodontia. However these findings need to be further validated in larger trails using specific standardized characteristics of laser settings to uniform the methodological design that can be used in routine clinical practice. |
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| Gil A et al.31 | J Craniomaxillofac Surg. | 2018 | Corticotomy facilitated orthodontics resulted in decreased treatment time. Few complications and low morbitidy were found. More solid evidence based research is required to support these results. |
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| Kamal A et al.32 | International Orthodontics | 2019 | Adverse Effect not mentioned |
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| Gkantidis N et al.33 | Journal of Dentistry | 2014 | Adverse Effect not mentioned |
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| Iglesias-Linares A et al.34 | Orthod Craniofac Res | 2011 | Adverse Effect not mentioned |
| Misleading Interpretation | Jing D et al.35 | BMC Oral Health. | 2017 | Aim of study was to systematically evaluate the available evidences on the efficacy of vibrational stimulus to accelerate OTM, to which they concluded :Within the limitations of this review, weak evidence indicates that vibrational stimulus is effective for accelerating canine retraction but not for alignment. The effects of vibration on pain intensity and root resorption during orthodontic treatment are inconclusive |
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| Aljabaa A et al.36 | Am J Orthod Dentofacial Orthop. | 2018 | Treatment is beneficial despite lack of evidence. |
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| Dab S et al.37 | Orthod Craniofac Res. | 2019 | Current evidence suggests a very low to low level of certainty (GRADE assessment) in regard to quantified effects after CAOOT. Although CAOOT procedures show insignificant increase in the density following the use of bone graft and anchorage loss, they appear to accelerate the tooth movement during the first few months, to increase the buccal bone thickness and to show good tolerance by the patients; the clinical significance of these changes may be considered questionable. |
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| Viwattanatipa N et al.38 | Korean J Orthod. | 2018 | Treatment is beneficial despite lack of evidence. |
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| Farshidfar N et al.39 | Int Orthod. | 2021 | According to the low certainty of evidence about this topic, providing a definite conclusion is not possible. However, applying I-PRF seems to be efficient in accelerating the OTM of the canines. |
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| Apalimova A et al.40 | Heliyon | 2020 | High heterogeneity among studies made it difficult to draw clear conclusions. However, within the limitations of this review, the corticotomy procedures were able to statistically and clinically produce significant temporary decrease in orthodontic tooth movement rate. |
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| Gkantidis N et al.33 | J Dent. | 2014 | Treatment is beneficial despite lack of evidence. |
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| Almeida V et al.41 | J Photochem Photobiol B. | 2016 | Three articles detected statistically significant differences in induced movement by comparing the orthodontic movement between the experimental and control groups. For the maxilla, there was a statistically significant influence of the laser in three months and, for the mandible, in one month. It may be concluded that there is no evidence that laser therapy can accelerate the induced tooth movement. |
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| Fleming P et al.42 | Cochrane Database Syst rev. | 2015 | The available evidence is of low quality, which indicates that further research is likely to change the estimate of the effect. Based on measured outcomes in the short-term, these procedures do appear to show promise as a means of accelerating tooth movement. |
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| Yi J et al.43 | Angle Orthod. | 2017 | Treatment is beneficial despite lack of evidence. |
| Misleading Extrapolation | Cronshaw M et al.44 | Photobiomodul Photomed Laser Surg. | 2019 | Overgeneralisation of result for clinical logistics associated with frequent applications supports the concept of patient home delivery use of LED devices. |
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| Hassan A et al.45 | Saudi Med J. | 2015 | Results of study said CAOT was found to accelerate tooth movement by 2–2.5 folds when compared with conventional orthodontic tooth movement. Conclusion- CAOT should be considered with caution. |
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| Eltimamy A et al.46 | Open Access Maced J Med Sci. | 2019 | Prostaglandin showed a marked increase in rate of OTM; while inconclusive evidence was found regarding Prostaglandin in the acceleration of OTM |
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| Parcianello R et al.47 | Orthod Craniofac Res. | 2021 | Twenty-four studies were included in the systematic review. On a specific dose level, epidermal growth factor + liposomes, fibroblast growth factor and prostaglandin E2 + Ca were supported by a moderate level of evidence and rated as highly effective in increasing tooth movement in animal models. Hormones and growth factors may have a relevant impact upon orthodontic tooth movement rate. In specific formulations, prostaglandin E2, fibroblast growth factor and epidermal growth factor showed promising results. |
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| Long Hu et al.48 | Angle Orthod. | 2013 | Among the five interventions, corticotomy is effective and safe to accelerate orthodontic tooth movement, low-level laser therapy was unable to accelerate orthodontic tooth movement, current evidence does not reveal whether electrical current and pulsed electromagnetic fields are effective in accelerating orthodontic tooth movement, and dentoalveolar or periodontal distraction is promising in accelerating orthodontic tooth movement but lacks convincing evidence. |
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| Yi J et al.49 | Journal of Oral Rehabilitation | 2017 | The quality of evidence ranged from very low to low. The short-term (1–3 months) effects of low-level laser therapy (LLLT, 5 and 8 J cm2) and corticotomy were supported by low-quality evidence.We conclude that low quality evidence indicates that LLLT (5 and 8 J cm2) and corticotomy are effective to promote OTM in the short term. |
