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Impact of Herbal Blends Supplementation on the Mineral Profile of Blood Plasma and Milk of Dairy Cows* Cover

Impact of Herbal Blends Supplementation on the Mineral Profile of Blood Plasma and Milk of Dairy Cows*

Open Access
|Jul 2025

References

  1. Abo El-Maaty A.M., Aly M.A., Kotp M.S., Ali A.H., El Gabry M. A. (2021). The effect of Seasonal heat stress on oxidants–antioxidants biomarkers, trace minerals and acute-phase response of periparturient Holstein Friesian cows supplemented with adequate minerals and vitamins with and without retained fetal membranes. Bull. Natl. Res. Cent., 45: 1–7.
  2. Aleri J.W., Hine B.C., Pyman M.F., Mansell P.D., Wales W.J., Mallard B., Fisher A.D. (2016). Periparturient immunosuppression and strategies to improve dairy cow health during the periparturient period. Res. Vet. Sci., 108: 8–17.
  3. AlSuwaiegh S.B., Almotham A.M., Alyousef Y.M., Mansour A.T., Al-Sagheer A.A. (2022). Influence of functional feed supplements on the milk production efficiency, feed utilization, blood metabolites, and health of Holstein cows during mid-lactation. Sustain Sci., 14: 8444.
  4. AOAC (2011). Association of Official Analytical Chemists. Official Methods of Analysis. Gaithersburg, MD, USA, 17th ed.
  5. Aschenbach J.R., Penner G.B., Stumpff F., Gäbel G. (2011). Ruminant nutrition symposium: role of fermentation acid absorption in the regulation of ruminal pH. J. Anim. Sci., 89: 1092–1107.
  6. Ayrle H., Schmid K., Disler M., Bischoff T., Stucki K., Zbinden M., Vogl C.R., Hamburger M., Walkenhorst M. (2015). Plant species reported from Swiss farmers to treat bovine respiratory diseases. Planta Medica, 81.
  7. Barros R.G., Lodde V., Dieci C., Fraciosi F., Luciano A.M. (2018). Study on the effects of zinc supplementation during in vitro embryo production technologies in cattle. Proc. Veterinary and Animal Science Days 2018, 6–8.06.2018, Milan, Italy.
  8. Bates A.J., Wells M., Laven R.A. (2022). The effect of pre-calving injection of trace mineral supplements on periparturient disease incidence in pasture based dairy cows. Vet. J., 286: 105867.
  9. Bhatt N. (2015). Herbs and herbal supplements, a novel nutritional approach in animal nutrition. Iran. J. Appl. Anim. Sci., 5: 497–516.
  10. Bijl E., van Valenberg H.J.F., Huppertz T., van Hooijdonk A.C.M. (2013). Protein, casein, and micellar salts in milk: Current content and historical perspectives. J. Dairy Sci., 96: 5455–5464.
  11. Borowska S., Brzoska M.M., Tomczyk M. (2018). Complexation of bioelements and toxic metals by polyphenolic compounds –implications for health. Curr. Drug Targets, 19: 1612–1638.
  12. Cui Y., Shan Z., Hou L., Wang Q., Loor J.J., Xu C. (2021). Effect of natural Chinese herbal supplements (TCMF4) on lactation performance and serum biomarkers in peripartal dairy cows. Front. Vet. Sci., 8: 801418.
  13. Daniel J.B., Kvidera S.K., Martín-Tereso J. (2020). Total-tract digestibility and milk productivity of dairy cows as affected by trace mineral sources. Int. J. Dairy Sci., 103: 9081–9089.
  14. Davis S.R., Farr V.C., Knowles S.O., Lee J., Kolver E., Auldist M.J. (2001). Sources of variation in milk calcium content. Aust. J. Dairy Tech., 56: 156.
  15. Del Río-Avilés A.D., Correa-Calderón A., Avendaño-Reyes L., Macías-Cruz U., Thomas M.G., Enns R.M., Speidel S.E., Sánchez-Castro M.A., Zamorano-Algandar R., López-Castro P.A., Luna-Nevárez P. (2022). Mineral supplementation (injectable) improved reproductive performance in Holstein cows managed in a warm summer environment. Reprod. Domest. Anim., 57: 839–848.
  16. Dembek R., Łyszczarz R., Zimmer-Grajewska M. (2014). Plantago lanceolata L. as a component of permanent and renewed grasslands. Acta Sci. Pol. Agric., 13: 19–30.
  17. Denholm S.J., Sneddon A.A., McNeilly T.N., Bashir S., Mitchell M.C., Wall E. (2019). Phenotypic and genetic analysis of milk and serum element concentrations in dairy cows. J. Dairy Sci., 102: 11180–11192.
  18. Di Meo M.C., Salzano A., Zotti T., Palladino A., Giaquinto D., Maruccio L., Varricchio E. (2023). Plasma fatty acid profile in Italian Holstein-Friesian dairy cows supplemented with natural polyphenols from the olive plant Olea Europaea L. Vet. and Anim. Sci., 21: 100298.
  19. Dunshea F.R., Walker G.P., Williams R., Doyle P.T. (2019). Mineral and citrate concentrations in milk are affected by seasons, stage of lactation and management practices. Agricultuere, 9: 25.
  20. Dymtów I., Włodarczyk K. (2022). Composition and nutritional value of mare and donkey milk compared to milk from cows. Food. Sci. Technol. Qual., 27: 28–39.
  21. El-Saadony M.T., Yang T., Saad A.M., Alkafaas S.S., Elkafas S.S., Eldeeb G.S., Lorenzo J.M. (2024). Chemistry, bioavailability, bio-activity, nutritional aspects and human health benefits of polyphenols: A comprehensive review. Int. J. Biol. Macromol., 134223.
  22. Erickson P.S., Kalscheur K.F. (2020). Nutrition and feeding of dairy cattle. Anim. Agric., 157–180.
  23. Ezzat Abd El-Hack M., Alagawany M., Ragab Farag M., Tiwari R., Karthik K., Dhama K., Adel M. (2016). Beneficial impacts of thymol essential oil on health and production of animals, fish and poultry: a review. J. Essent. Oil Res., 28: 365–382.
  24. Fabjanowska J., Kowalczuk-Vasilev E., Klebaniuk R., Milewski S., Gümüş H. (2023). N-3 polyunsaturated fatty acids as a nutritional support of the reproductive and immune system of cattle –a review. Animals, 13: 3589.
  25. Fabjanowska J., Kowalczuk-Vasilev E., Klebaniuk R. (2024). Effectiveness of the use of herbal mixtures in feeding calves of meat breeds (in Polish). Sust. Anim. Prod., 49.
  26. Fadlalla I.M.T., Omer S.A., Atta M. (2020). Determination of some serum macroelement minerals levels at different lactation stages of dairy cows and their correlations. African J. Sci., 8: e00351.
  27. Fu Y., Colazo M.G., De Buck J. (2022). Development of a blood calcium test for hypocalcemia diagnosis in dairy cows. Res. Vet. Sci., 147: 60–67.
  28. Gaignon P., Le Grand K., Laza-Knoerr A.L., Hurtaud C., Boudon A. (2019). Effect of calcium intake and the dietary cation-anion difference during early lactation on the bone mobilization dynamics throughout lactation in dairy cows. PloS One, 14(11): e0218979.
  29. Goff J.P. (2018). Invited review: Mineral absorption mechanisms, mineral interactions that affect acid-base and antioxidant status, and diet considerations to improve mineral status. J. Dairy Sci., 101: 2763–2813.
  30. Grünberg W. (2023). Phosphorus metabolism during transition. Vet. Clin. N. Am. –Food Anim. Pract., 39: 261–274.
  31. Harvey K.M., Cooke R.F., Marques R.D.S. (2021). Supplementing trace minerals to beef cows during gestation to enhance productive and health responses of the offspring. Animals, 11: 1159.
  32. Hashemzadeh-Cigari F., Khorvash M., Ghorbani G.R., Kadivar M., Riasi A., Zebeli Q. (2014). Effects of supplementation with a phytobiotics-rich herbal mixture on performance, udder health, and metabolic status of Holstein cows with various levels of milk somatic cell counts. J. Dairy Sci., 97: 7487–7497.
  33. INRA (2019). INRA feeding system for ruminants (2nd ed). Wageningen Academic Publishers, Wageningen, the Netherlands, 640 pp.
  34. Jacob M.P., Cazaubon M., Scemama A., Prié D., Blanchet F., Guillin M.C., Michel J.B. (2002). Plasma matrix metalloproteinase-9 as a marker of blood stasis in varicose veins. Circulation, 106: 535–538.
  35. Jarzynowska A., Peter E. (2017). Effect of adding herbs to winter diet on fatty acid profile of lipid fraction of sheep milk (in Polish). Rocz. Nauk. Pol. Tow. Zootech., 13: 43–54.
  36. Keanthao P., Goselink R.M.A., Dijkstra J., Bannink A., Schonewille J.T. (2021). Effects of dietary phosphorus concentration during the transition period on plasma calcium concentrations, feed intake, and milk production in dairy cows. J. Dairy Sci., 104: 11646–11659.
  37. Kebreab E., Odongo N.E., McBride B.W., Hanigan M.D., France J. (2008). Phosphorus utilization and environmental and economic implications of reducing phosphorus pollution from Ontario dairy cows. J. Dairy Sci., 91: 241–246.
  38. Khachlouf K., Hamed H., Gdoura R., Gargouri A. (2019). Effects of dietary zeolite supplementation on milk yield and composition and blood minerals status in lactating dairy cows. J. Appl. Anim., 47: 54–62.
  39. Kholif A.E., Hassan A.A., El Ashry G.M., Bakr M.H., El-Zaiat H.M., Olafadehan O.A., Sallam S.M.A. (2021). Phytogenic feed additives mixture enhances the lactational performance, feed utilization and ruminal fermentation of Friesian cows. Anim. Biotech., 32: 708–718.
  40. Kiczorowska B., Samolińska W., Al-Yasiry A.R.M., Kiczorowski P., Winiarska-Mieczan A. (2017). The natural feed additives as immunostimulants in monogastric animal nutrition–a review. Ann. Anim. Sci., 17: 605–625.
  41. Kikusato M. (2021). Phytobiotics to improve health and production of broiler chickens: functions beyond the antioxidant activity. Anim. Biosci., 34: 345.
  42. Klebaniuk R., Grela E.R., Kowalczuk-Vasilev E., Olcha M., Góźdź J. (2014). Effectiveness of using herbal mixtures in organic cattle breeding (in Polish). Wiad. Zoot., 52: 56–63.
  43. Klebaniuk R., Kowalczuk-Vasilev E., Bąkowski M., Rocki G., Grela E.R., Kiczorowska B., Matras J., Widz J., Kępka K. (2017). Effectiveness of herbal mixture use (in Polish). Med. Weter., 73: 751–755.
  44. Klop G., Ellis J.L., Blok M.C., Brandsma G.G., Bannink A., Dijkstra J. (2014). Variation in phosphorus content of milk from dairy cattle as affected by differences in milk composition. J. Agric. Sci., 152: 860–869.
  45. Korać R.S., Huremović J., Žero S., Ljubijankić N. (2023). Content of metals in cow, sheep and goat milk samples. Bull. Chem. Technol. Bosnia Herzeg., 60: 1–6.
  46. Kozłowska M., Laudy A.E., Przybył J., Ziarno M., Majewska E. (2015). Chemical composition and antibacterial activity of some medicinal plants from the Lamiaceae family. Acta Pol. Pharm., 72: 757–767.
  47. Krawęcka A., Sobota A., Ivanišová E., Harangozo Ľ., Valková V., Zielińska E., Mildner-Szkudlarz S. (2022). Effect of black cumin cake addition on the chemical composition, glycemic index, anti-oxidant activity, and cooking quality of durum wheat pasta. Molecules, 27: 6342.
  48. Kumar M., Kumar V., Roy D., Kushwaha R., Vaiswani S. (2014). Application of herbal feed additives in animal nutrition –a review. Int. J. Livest. Res., 4: 1–8.
  49. Kuralkar P., Kuralkar S.V. (2021). Role of herbal products in animal production –an updated review. J. Ethnopharmacol., 278: 114246.
  50. Kurek Ł., Lutnicki K., Kluciński W., Kleczkowski M., Brodzki P., Marczuk J., Gołyński M. (2015). Effect of hypocalcemia on parenchymal organ function in cows at the peak of lactation (in Polish). Med. Weter., 71: 307–311.
  51. López-Alonso M., Miranda M. (2020). Copper supplementation, a challenge in cattle. Animals, 10: 1890.
  52. Luna D., López-Alonso M., Cedeño Y., Rigueira L., Pereira V., Miranda M. (2019). Determination of essential and toxic elements in cattle blood: serum vs plasma. Animals, 9: 465.
  53. Mahen P.J., Williams H.J., Smith R.F., Grove-White D. (2018). Effect of blood ionized calcium concentration at calving on fertility outcomes in dairy cattle. Vet Rec., 83: 263.
  54. Manuelian C.L., Penasa M., Visentin G., Zidi A., Cassandro M., De Marchi M. (2018). Mineral composition of cow milk from multi-breed herds. Anim. Sci. J., 89: 1622–1627.
  55. Mascitelli L., Goldstein M.R. (2014). Inhibition of iron absorption by polyphenols as an anticancer mechanism. In: Polyphenols in Human Health and Disease. Acad. Press., pp. 1283–1286.
  56. Mehra R., Singh R., Nayan V., Buttar H.S., Kumar N., Kumar S., Kumar H. (2021). Nutritional attributes of bovine colostrum components in human health and disease: a comprehensive review. Food Biosci., 40: 100907.
  57. Meir Y.A.B., Shaani Y., Bikel D., Portnik Y., Jacoby S., Moallem U., Frank E. (2023). Reducing dietary sodium of dairy cows fed a low-roughages diet affect intake and feed efficiency, but not yield. Anim. Nutr., 12: 1–6.
  58. Mirowski A. (2019). Utility of herbs in cattle nutrition (in Polish). Życie Wet., 92: 131–133.
  59. Mordak R., Dobrzański Z., Kupczyński R. (2021). Relationships among macro-minerals, other selected serum markers of bone profile and milk components of dairy cows during late lactation. Ann. Anim. Sci., 21: 887–898.
  60. Muttepawar S.S., Jadhav S.B., Kankudate A.D., Sanghai S.D., Usturge D.R., Chavare S.S. (2014). A review on bioavailability enhancers of herbal origin. Word J. Pharm. Sci., 3: 667–677.
  61. NASEM (2021). National Academies of Sciences, Engineering, and Medicine. Nutrient Requirements of Dairy Cattle: Eighth Revised Edition. Washington, DC: The National Academies Press.
  62. Nogalska A., Momot M., Sobczuk-Szul M., Pogorzelska-Przybyłek P., Nogalski Z. (2017). Calcium and magnesium content in the milk of high-yielding cows. J. Elem., 22: 809–815.
  63. Nozad S., Ramin A.G., Moghadam G., Asri-Rezaei S., Babapour A., Ramin S. (2012). Relationship between blood urea, protein, creatinine, triglycerides and macro-mineral concentrations with the quality and quantity of milk in dairy Holstein cows. Vet. Res. Forum., 3: 55.
  64. Orjales I., Herrero-Latorre C., Miranda M., Rey-Crespo F., Rodríguez-Bermúdez R., López-Alonso M. (2018). Evaluation of trace element status of organic dairy cattle. Animal, 12: 1296–1305.
  65. Paskudzka A., Kołodziejczyk D., Socha S. (2018). The use of herbs in animals. Acta Sci. Pol. Zootech., 17: 3–14.
  66. Pilarczyk J., Wójcik P., Czerniak P., Sablik B., Pilarczyk A., Tomza-Marciniak A. (2013). Concentrations of toxic heavy metals and trace elements in raw milk of Simmental and Holstein-Friesian cows from organic farm. Environ. Monit. Assess., 185: 8383–8392.
  67. Proskura N., Podlasińska J., Proskura W.S., Frost-Rutkowska A., Dybus A., Szydłowski K. (2017). Concentrations of macroelements and trace elements in milk of Jersey cows. Indian J. Anim. Res., 51: 89–92.
  68. Puppel K., Kuczyńska B. (2016). Metabolic profiles of cow’s blood; a review. J. Sci. Food Agric., 96: 4321–4328.
  69. Rabiei S., Zahedi M., Abtahi M., Doustmohammadian A., Dadkhah M., Zoghi T., Hajigholam-Saryazdi M. (2021). Consumption of milk and dairy products in Iranian population; barriers and facilitators. Clin. Nutr. Exp., 38: 1–23.
  70. Redoy M.R.A., Shuvo A.A.S., Cheng L., Al-Mamun M. (2020). Effect of herbal supplementation on growth, immunity, rumen histology, serum antioxidants and meat quality of sheep. Animal, 14: 2433–2441.
  71. Rivera-Chacon R., Castillo-Lopez E., Ricci S., Petri R.M., Reisinger N., Zebeli Q. (2022). Supplementing a phytogenic feed additive modulates the risk of subacute rumen acidosis, rumen fermentation and systemic inflammation in cattle fed acidogenic diets. Animals, 12: 1201.
  72. Saha S., Piazza M., Bittante G., Gallo L. (2021). Macro- and micro-mineral composition of milk from purebred Holsteins and four generations of three-breed rotational crossbred cows from Viking Red, Montbéliarde and Holstein sires. Ital. J. Anim. Sci., 20: 447–452.
  73. Sahraeian S., Rashidinejad A., Golmakani M.T. (2024). Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols. F. Hydro., 146: 109221.
  74. Seyfaddinov S. (2022). What is the share of balanced quality feed? J. Appl. Sci., 5: 21–26.
  75. Shan C.H., Guo J., Sun X., Li N., Yang X., Gao Y., Zhao J.J. (2018). Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions. J. Anim. Sci., 96: 4444–4457.
  76. Sharma N., Kundu S.S., Tariq H., Mani V., Malhotra R. (2021). Effect of fat and protein along with polyherbal preparation on reproductive health of periparturient Karan Fries cows. Indian J. Anim. Res., 55: 657–62.
  77. Shilpashree B.G., Arora S., Chawla P., Sharma V. (2022). A comparison of zinc interactions with succinylated milk protein concentrate and sodium caseinate. LWT, 157: 113116.
  78. Shkembi B., Huppertz T. (2021). Influence of dairy products on bio-availability of zinc from other food products: A review of complementarity at a meal level. Nutrition, 13: 4253.
  79. Singleton V.L., Rossi J.A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic., 16: 144–158.
  80. Spek J.W., Bannink A., Gort G., Hendriks W.H., Dijkstra J. (2012). Effect of sodium chloride intake on urine volume, urinary urea excretion, and milk urea concentration in lactating dairy cattle. J. Dairy Sci., 95: 7288–7298.
  81. Stobiecka M., Król J., Brodziak A., Klebaniuk R., Kowalczuk-Vasilev E. (2023). Effects of supplementation with an herbal mixture on the antioxidant capacity of milk. Animals, 13: 2013.
  82. Stocco G., Summer A., Malacarne M., Cecchinato A., Bittante G. (2019). Detailed macro-and micromineral profile of milk: Effects of herd productivity, parity, and stage of lactation of cows of 6 dairy and dual-purpose breeds. J. Dairy Sci., 102: 9727–9739.
  83. Strzetelski J.A., Brzóska F., Kowalski Z.M., Osięgłowski S. (2014). Nutritional recommendations for ruminants and feed value tables (in Polish). Kraków, Poland, National Research Institute of Animal Production, 287 pp.
  84. Sun F., Cao Y., Cai C., Li S., Yu C., Yao J. (2016). Regulation of nutritional metabolism in transition dairy cows: Energy homeostasis and health in response to post-ruminal choline and methionine. PloS one, 11(8), e0160659.
  85. Tamminen L.M., Emanuelson U., Blanco-Penedo I. (2018). Systematic review of phytotherapeutic treatments for different farm animals under European conditions. Front. Vet. Sci., 5: 140.
  86. Toscano A., Giannuzzi D., Pegolo S., Vanzin A., Bisutti V., Gallo L., Trevisi E., Cecchinato A., Schiavon S. (2023). Associations between the detailed milk mineral profile, milk composition, and metabolic status in Holstein cows. J. Dairy Sci., 106: 6577–6591.
  87. Tsiamadis V., Banos G., Panousis N., Kritsepi-Konstantinou M., Arsenos G., Valergakis G.E. (2016). Genetic parameters of calcium, phosphorus, magnesium, and potassium serum concentrations during the first 8 days after calving in Holstein cows. J. Dairy Sci., 99: 5535–5544.
  88. Tuhy Ł., Dmytryk A., Samoraj M., Chojnacka K. (2018). Trace elements in animal nutrition. In: Recent advances in trace elements, Chojnacka K., Saeid A. (eds). Wiley Blackwell, pp. 319–337.
  89. Van Emon M., Sanford C., McCoski S. (2020). Impacts of bovine trace mineral supplementation on maternal and offspring production and health. Animals, 10: 2404.
  90. Visentin G., De Marchi M., Berry D.P., McDermott A., Fenelon M.A., Penasa M., McParland S. (2017). Factors associated with milk processing characteristics predicted by mid-infrared spectroscopy in a large database of dairy cows. J. Dairy Sci., 100: 3293–3304.
  91. Wächter S., Cohrs I., Golbeck L., Wilkens M.R., Grünberg W. (2022). Effects of restricted dietary phosphorus supply to dry cows on periparturient calcium status. J. Dairy Sci., 105: 748–760.
  92. Wilkens M.R., Muscher-Banse A.S. (2020). Regulation of gastrointestinal and renal transport of calcium and phosphorus in ruminants. Animal, 14: 29–43.
  93. Winnicka A. (2021) Reference values for basic laboratory tests in veterinary medicine (in Polish). SGGW, Warsaw, Poland, 113 pp.
  94. Wójtowski J.A., Majcher M., Danków R., Pikul J., Mikołajczak P., Molińska-Glura M., Stanisławski D. (2023). Effect of herbal feed additives on goat milk volatile flavor compounds. Foods, 12: 2963.
  95. Xie Y., Chen Z., Wang D., Chen G., Sun X., He Q., Sun J. (2020). Effects of fermented herbal tea residues on the intestinal micro-biota characteristics of Holstein heifers under heat stress. Front. Microbiol., 11: 1014.
  96. Yaremchuk O.S., Farionik T.V. (2022). Effect of chelate compounds of microelements on the organism of agricultural animals. Mod. Eng. Innov. Technol., 23: 99–115.
  97. Yazlık M.O., Çolakoğlu H.E., Pekcan M., Kaya U., Küplülü Ş., Kaçar C., Vural M.R. (2021). Effects of injectable trace element and vitamin supplementation during the gestational, peri-parturient, or early lactational periods on neutrophil functions and pregnancy rate in dairy cows. Anim. Reprod. Sci., 225: 106686.
  98. Żarczyńska K., Żarczyński P., Sobiech P., Snarska A., Stopyra A., Wieteska M., Płaczek A. (2017). The effect of micronutrient deficiencies on the health status of transition cows. J. Elem., 22: 1223–1234.
DOI: https://doi.org/10.2478/aoas-2025-0015 | Journal eISSN: 2300-8733 | Journal ISSN: 1642-3402
Language: English
Page range: 1141 - 1153
Submitted on: Jul 25, 2024
Accepted on: Dec 19, 2024
Published on: Jul 24, 2025
Published by: National Research Institute of Animal Production
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Edyta Kowalczuk-Vasilev, Julia Fabjanowska, Renata Klebaniuk, Bożena Kiczorowska, Wioletta Samolińska, Olga Witkowska-Piłaszewicz, published by National Research Institute of Animal Production
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