References
- Ibrahim MA, Abdel-Karim RI, Tamam HG. Protective effect of Silymarin and ascorbic acid in valproic acid-induced hepatic toxicity in male albino rats. Mansoura J Forens Med Clin Toxicol. 2017;25(2).
- Omidipour R, Zarei L, Boroujeni MB, Rajabzadeh A. Protective effect of Thyme Honey against valproic acid hepatotoxicity in Wistar rats. Biomed Res Int. 2021;11.
- Anguissola G, Leu D, Simoetti GD. Kidney tubular injury induced by valproic acid: systemic literature review. Pediatr Nephrol. 2023;38:1725-1731.
- Perucca E. Pharmacological and therapeutic properties of valproate. CNS Drugs. 2002;16(10):695-714.
- Khan S, Ahmed T, Parekh CV. Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice. Reprod Toxicol. 2011;32(4):385-394.
- Tong V, Teng XW, Chang TKH, Abbott FS. Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci. 2005;86(2):427-435.
- AL-Rouby N, Gawish S. Histological study on the possible protective effect of Nigella sativa oil on experimentally induced hepatotoxicity in albino rats treated with sodium valproate. Global Adv Res J Med Med Sci. 2013;2(4):90-99.
- Pourahmad J, Eskandari MR, Kaghazi A. A new approach on valproic acid induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis. Toxicol In Vitro. 2012;26(4):545-551.
- Sokmen BB, Tunali S, Yanardag R. Effect of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats. Food Chem Toxicol. 2012;50(10):3562-3566.
- Pal R, Kumar B, Akhtar MJ, Chawla PA. Voltage gated sodium channel inhibitors as anticonvulsant drugs: A systematic review on recent developments and structure activity relationship studies. Bioorg Chem. 2021;115:105230.
- Sarlo GL, Holton KF. Brain concentrations of glutamate and GABA in human epilepsy: A review. Seizure. 2021;91:213-227.
- Safdar A, Ismail F. A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid. Saudi Pharm J. 2023;31(2):265-278.
- Hamza AA, El Hodairy, Badawi AM. Safranal ameliorates Sodium Valproate-induced liver toxicity in rats by targeting gene expression, oxidative stress and apoptosis. J Biomed Pharm Res. 2015;4(6):46-60.
- Akula B, Uduman MSTS, Chakka G. A comprehensive review on valproic acid induced liver injury. Int J Rev Life Sci. 2016;6(1):1-4.
- Knapp AC, Todesco L, Beier K. Toxicity of valproic acid in mice with decreased plasma and tissue Carnitine Stores. J Pharmacol Exp Ther. 2018;324(2):568-575.
- Shnayder, N.A.; Grechkina, V.V.; Khasanova, A.K.; Bochanova, E.N.; Dontceva, E.A.; Petrova, M.M.; Asadullin, A.R.; Shipulin, G.A.; Altynbekov, K.S.; Al-Zamil, M.; et al. Therapeutic and Toxic Effects of Valproic Acid Metabolites. Metabolites 2023
- Kesterson JW, Granneman GR, Machinist JM. The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies. Hepatology. 1984;4(6):1143-1152.
- Amrani A, Benaissa O, Boubekri N, et al. Impact of Chrysanthemum fontanesii extract on sodium valproate-mediated oxidative damage in mice kidney. J Appl Pharm Sci. 2016;6(4):67-71.
- Kiang TK, Teng XW, Surendradoss J, Karagiozov S, Abbott FS, Chang TKH. Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity. Toxicol Appl Pharmacol. 2011;252(3):318-324.
- Hansen JM, Lucas SM, Ramos CD et al., Valproic acid promotes SOD2 acetylation: A potential mechanism of valproic acid-induced oxidative stress in developing systems. Free Radic Res. 2021;55(11-12):1130-1144.
- Tong V, Teng XW, Chang TKH, Abbott FS. Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes. Toxicol Sci. 2005;86(2):436-443.
- Salsaa M, Pereira B, Liu J, et al. Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae. Sci Rep. 2020;10:11785.
- Shnayder NA, Grechkina VV, Khasanova AK et al., Therapeutic and Toxic Effects of Valproic Acid Metabolites. Metabolites. 2023;13(1):134.
- Hansen JM, Lucas SM, Ramos CD, Green EJ, Nuttall DJ, Clark DS, et al. Valproic acid promotes SOD2 acetylation: A potential mechanism of valproic acid-induced oxidative stress in developing systems. Free Radic Res. 2021;55(11-12):1130-1144.
- Patel N. The glutathione revolution: fight disease, slow aging, and increase energy with the master antioxidant. Hachette UK; 2020.
- Tung EW, Winn LM. Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: A role for oxidative stress in valproic acid induced neural tube defects. Mol Pharmacol. 2011;80:979-987.
- Juriam-Romet M, Abbott FS, Tang W, Huang HS. Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione depleted rat hepatocytes. Toxicology. 1996;112(1):69-85.
- Ibrahim M, Hassan W, Saeed MG. Nephrotoxicity Evaluation of Captopril and Enalapril in Rats: Comparative Study. Egyptian Journal of Veterinary Sciences. 2024;55(1):69-81.
- Adikwu E, Deo O. Hepatoprotective effect of vitamin C (ascorbic acid). Pharmacol Pharm. 2013;4(1):84-92.
- Ergul Y, Erkan T, Uzun H, et al. Effect of vitamin C on oxidative liver injury due to isoniazid in rats. Pediatr Int. 2010;52(1):69-74.
- Gupta M, Gupta YK, Agarwal S. A randomized, double-blind, placebo-controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. Br J Clin Pharmacol. 2004;58(5):542-547.
- Faehaa AA. Oxidative stress and Antioxidant defense Mechanisms in Dentistry: A Literature Review. Al-Rafidain Dent J. 2022;22(2):323-331.