The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An in vivo study in Cavia porcellus

Sri Oktawati; Nurlindah Hamrun; Muthmainnah Muthmainnah; Dian Setiawati; Andi Sitti Hajrah Yusuf

doi:10.2478/amma-2024-0015

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The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An in vivo study in Cavia porcellus

Acta Marisiensis - Seria Medica

Volume 70 (2024): Issue 2 (June 2024)

By: Sri Oktawati, Nurlindah Hamrun, Muthmainnah Muthmainnah, Dian Setiawati and Andi Sitti Hajrah Yusuf

Open Access

|Jul 2024

Abstract

Objective: This study aims to assess the effect of bone graft materials derived from pearl oyster shells on the tumor necrosis factor-alpha (TNF-α) level.

Methods: This research utilized a bone graft containing hydroxyapatite Pinctada maxima (HPM) powder obtained from pearl oyster shells. Material testing was conducted on 30 male guinea pigs aged 8-10 weeks, divided into three groups: the negative control group, the group treated solely with HPM, and the group treated with HPM combined with platelet-rich fibrin (PRF). Each treatment group was observed for 7 and 14 days. The results were analyzed using One-way ANOVA with a significance level of p<0.05.

Results: The findings demonstrated a decrease in the average TNF-α levels across all groups. On observation days 7 and 14, the HPM group exhibited a significant difference compared to the negative control group, indicating reduced TNF-α levels. However, no significant difference was observed when comparing the HPM group with the HPM and PRF groups.

Conclusions: Bone grafts derived from pearl oyster shells possess high levels of hydroxyapatite, and the addition of PRF into the bone graft effectively reduces TNF-α.

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Articles in this issue

DOI: https://doi.org/10.2478/amma-2024-0015 | Journal eISSN: 2668-7763 | Journal ISSN: 2668-7755

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Language: English

Page range: 68 - 74

Submitted on: Oct 24, 2023

Accepted on: Jun 3, 2024

Published on: Jul 3, 2024

Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

bone graft,

Pinctada maxima,

pearl oyster shells,

platelet-rich fibrin,

TNF-alfa

Related subjects:

Medicine,

Clinical medicine,

Clinical medicine, other

© 2024 Sri Oktawati, Nurlindah Hamrun, Muthmainnah Muthmainnah, Dian Setiawati, Andi Sitti Hajrah Yusuf, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 70 (2024): Issue 2 (June 2024)