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Determination of isohydrafural and methyluracil in ear drops by high performance liquid chromatography Cover

Determination of isohydrafural and methyluracil in ear drops by high performance liquid chromatography

By: Livia Uncu  
Open Access
|Dec 2023

References

  1. DeAntonio R, Yarzabal JP, Cruz JP, Schmidt JE, Kleijnen J. Epidemiology of otitis media in children from developing countries: a systematic review. Int J Pediatr Otorhinolaryngol. 2016; 85:65–74. doi: 10.1016/j. ijporl.2016.03.032
  2. Alizadeh M, Jalal M, Hamed K, et al. Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives. J Inflamm Res. 2020 A; 13:451-463. doi: 10.2147/JIR.S262132
  3. Le VVH, Rakonjac J. Nitrofurans: Revival of an „old” drug class in the fight against antibiotic resistance. PLoS Pathog. 2021; 17(7):e1009663. doi: 10.1371/journal.ppat.1009663.
  4. Dighe NS. et al. Synthetic and pharmacological profile of furan. Asian Journal of Biosciences 2014; 1(1), 7-14. ISSN 1996-3351.
  5. Kumar V. Antimicrobial potential of hydrazone scaffold. International Journal of Academic Research and Development 2018; 3(2), 9-12. ISSN 2455-4197.
  6. Rusu A, Moga I-M, Uncu L, Hancu G. The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy. Pharmaceutics 2023; 15, 2554. doi:10.3390/ pharmaceutics15112554
  7. Sadlowski C, Park B, Araujo C, et al. Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics. Mol Syst Des Eng. 2018; 3(4):599–603. doi: 10.1039/C8ME00011E
  8. Stevens M, Howe C, Ray AM, et al. Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs. Bioorg Med Chem. 2020; 28(22):115710. doi: 10.1016/j.bmc.2020.115710
  9. Lyu J, Wang S, Balius TE, et al. Ultra-large library docking for discovering new chemotypes. Nature. 2019; 566(7743):224–9. doi: 10.1038/ s41586-019-0917-9
  10. Prisacari V. et al. New antibacterial and antifungal substances from local raw material. Akademos 2010; 17(2), 66-75. ISSN 1857-0461.
  11. Stoica AE, Chircov C, Grumezescu AM. Nanomaterials for wound dressings: an up-to-date overview. Molecules 2020; 25:2699. doi: 10.3390/molecules25112699.
  12. Kun Harismah, Ramona Khadivi, Ebrahim Balali, et al. Hydrogen-Bonded Dimers of 2-Thiouracil: Insights from Computational Analyses. Biointerface Research in Applied Chemistry 2023; 13 (6), 552. Doi:10.33263/BRIAC136.552
  13. Plecheva D, Alekhin E. Oxymethyluracil stimulates reparative regeneration of skin in rats. Eksp. Klin, Farmakol. 2004, 5(67), 63-66. ISSN: 0869-2092
  14. Donici E. Development, analysis and standardization of combined pharmaceutical forms containing Isohydrafural. Doctoral Thesis in Pharmaceutical Sciences 2020. 279 p.
  15. Leonidov NB, Kolesnikova MA, Seleznev NG, Cherkunov BF, Tarapina TV. A new pyrimidine-series preparation in the treatment of experimental chemical eye burns. Oftalmol Zh. 1990; (6):344-7.
  16. Grabovskiy S, Kabal’nova N, Andriayshina N, et al. In vitro proliferative activity of 6-substituted uracil derivatives. Journal of Pharmacy & Pharmacognosy Research 2021; 9, 357-365. doi:10.56499/ jppres20.944_9.3.357.
  17. Uncu L, et al. Compatibility study of isohydrafural and methyluracil in the same pharmaceutical form. Scientific Annals of USMF „Nicolae Testemiţanu” 2010; 423-427. ISSN 1857-1719.
  18. Spînu C, Lupu R, Podgornîi A, Nicolai E. Evaluation of methods for determining the ototoxicity of drug substances. Book of abstracts of The 7th International Medical Congress for Students and Young Doctors, May 3-5, 2018; 276-277.
  19. Romanova EV, Samoukova TS, Sanaeva EP, Saushkina AS, Fomicheva VI. Development of methods for analyzing an ointment containing anesthesin, methyluracil, furatsilin [Electronic resource] // Ogarev-online. 2020; 1. Access mode: https://journal.mrsu.ru/arts/razrabotkasposobov-analiza-mazi-soderzhashhej-anestezin-metiluracil-furacilin . Accessed 22 Sept 2023.
  20. Melnikov AM, Bocharnikova KS. Quantitative determination of methyluracil in soft dosage form with silver nanoparticles by spectrophotometric method. Current issues of science and practice, Collection of scientific articles based on the materials of the VIII International Scientific and Practical Conference. Ufa, 2022; 175-179. eLIBRARY ID: 48547427, available: https://www.elibrary.ru/item.asp?id=48547427, accesat 09/20/2023. Accessed 21 Sept 2023.
  21. Uncu A. Development and validation of the high-pressure liquid chromatographic method for the quantitative determination of propylthiohinothiadiazole. Moldovan Medical Journal. 2020;63(3), 32-37. doi:10.5281/zenodo.3958549
  22. Nicolai E, Vislouh O, Valica V, Parii S, Uncu L. Stability studies of combined ear drops for the treatment of otitis. Moldovan Medical Journal 2020,63(3), 43-50. doi: 10.5281/zenodo.3958557
  23. ICH Harmonised tripartite guideline Q2(R1). Validation of Analytical Procedure: Methodology. International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use. 2005; Available from: https://database.ich.org/sites/default/files/Q2_R1__Guideline.pdf . Accessed 22 Sept 2023.
  24. Forootan A, RSj¨oback, JBj¨orkman, B.j¨ogreen, LLinz,and M Kubista. Methods to determine limit of detection and limit of quantification in quantitative real-time PCR (qPCR). Biomolecular Detection and Quantification 2017; 3, 1–6. doi: 10.1016/j.bdq.2017.04.001.
DOI: https://doi.org/10.2478/amma-2023-0049 | Journal eISSN: 2668-7763 | Journal ISSN: 2668-7755
Language: English
Page range: 285 - 291
Submitted on: Nov 7, 2023
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Accepted on: Dec 4, 2023
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Published on: Dec 28, 2023
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Livia Uncu, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.