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Apathy as Non-Motor Manifestation in Amyotrophic Lateral Sclerosis Cover

Apathy as Non-Motor Manifestation in Amyotrophic Lateral Sclerosis

Open Access
|Apr 2022

References

  1. 1. Cui F, Zhu W, Zhou Z, et al. Frequency and risk factor analysis of cognitive and anxiety-depressive disorders in patients with amyotrophic lateral sclerosis/motor neuron disease. Neuropsychiatr Dis Treat. 2015 Nov 3;11:2847-5410.2147/NDT.S90520
  2. 2. Benbrika S, Desgranges B, Eustache F, Viader F. Cognitive, Emotional and Psychological Manifestations in Amyotrophic Lateral Sclerosis at Baseline and Overtime: A Review. Front Neurosci. 2019 Sep 10;13:95110.3389/fnins.2019.00951
  3. 3. Abrahams S, Leigh PN, Harvey A, Vythelingum GN, Grisé D, Goldstein LH. Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia. 2000;38(6):734-4710.1016/S0028-3932(99)00146-3
  4. 4. Goldstein LH, Abrahams S. Changes in cognition and behaviour in amyotrophic lateral sclerosis: nature of impairment and implications for assessment. Lancet Neurol. 2013 Apr;12(4):368-8010.1016/S1474-4422(13)70026-7
  5. 5. De Marchi F, Sarnelli MF, Solara V, Bersano E, Cantello R, Mazzini L. Depression and risk of cognitive dysfunctions in amyotrophic lateral sclerosis. Acta Neurol Scand. 2019 May;139(5):438-44510.1111/ane.1307330712314
  6. 6. Pender N, Pinto-Grau M, Hardiman O. Cognitive and behavioural impairment in amyotrophic lateral sclerosis. Curr Opin Neurol. 2020 Oct;33(5):649-65410.1097/WCO.000000000000086232833751
  7. 7. Abrahams S, Newton J, Niven E, Foley J, Bak TH. Screening for cognition and behaviour changes in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Mar;15(1-2):9-1410.3109/21678421.2013.80578423781974
  8. 8. Carelli L, Solca F, Faini A, et al. The Complex Interplay Between Depression/Anxiety and Executive Functioning: Insights From the ECAS in a Large ALS Population. Front Psychol. 2018 Apr 5;9:45010.3389/fpsyg.2018.00450589575429674987
  9. 9. Femiano C, Trojsi F, Caiazzo G, et al. Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis. Behav Neurol. 2018 Oct 22;2018:263520210.1155/2018/2635202621790230425751
  10. 10. Radakovic R, Stephenson L, Colville S, Swingler R, Chandran S, Abrahams S. Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale. J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):663-910.1136/jnnp-2015-31077226203157
  11. 11. Marin RS. Apathy: Concept, Syndrome, Neural Mechanisms, and Treatment. Semin Clin Neuropsychiatry. 1996 Oct;1(4):304-314 -abstract
  12. 12. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991 Summer;3(3):243-54 - abstract10.1176/jnp.3.3.2431821241
  13. 13. Strong MJ, Abrahams S, Goldstein LH, et al. Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria. Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):153-17410.1080/21678421.2016.1267768740999028054827
  14. 14. Levy R. Apathy: a pathology of goal-directed behaviour: a new concept of the clinic and pathophysiology of apathy. Rev Neurol (Paris). 2012 Aug-Sep;168(8-9):585-9710.1016/j.neurol.2012.05.00322921248
  15. 15. Caga J, Hsieh S, Highton-Williamson E, et al. Apathy and its impact on patient outcome in amyotrophic lateral sclerosis. J Neurol. 2018 Jan;265(1):187-19310.1007/s00415-017-8688-429189922
  16. 16. Radakovic R, Stephenson L, Newton J, et al. Multidimensional apathy and executive dysfunction in amyotrophic lateral sclerosis. Cortex. 2017 Sep;94:142-15110.1016/j.cortex.2017.06.02328759804
  17. 17. Le Heron C, Holroyd CB, Salamone J, Husain M. Brain mechanisms underlying apathy. J Neurol Neurosurg Psychiatry. 2019 Mar;90(3):302-31210.1136/jnnp-2018-318265651846630366958
  18. 18. Woolley SC, Zhang Y, Schuff N, Weiner MW, Katz JS. Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI. Amyotroph Lateral Scler. 2011 Jan;12(1):52-810.3109/17482968.2010.52184221271791
  19. 19. Massimo L, Powers JP, Evans LK, et al. Apathy in Frontotemporal Degeneration: Neuroanatomical Evidence of Impaired Goal-directed Behavior. Front Hum Neurosci. 2015 Nov 10;9:61110.3389/fnhum.2015.00611463960126617508
  20. 20. Caga J, Tu S, Dharmadasa T, et al. Apathy is associated with parietal cortical-subcortical dysfunction in ALS. Cortex. 2021 Mar 23:S0010-9452(21)00103-
  21. 21. Tumati S, Martens S, de Jong BM, Aleman A. Lateral parietal cortex in the generation of behavior: Implications for apathy. Prog Neurobiol. 2019 Apr;175:20-3410.1016/j.pneurobio.2018.12.00330590096
  22. 22. De Marchi F, Sarnelli MF, Solara V, Bersano E, Cantello R, Mazzini L. Depression and risk of cognitive dysfunctions in amyotrophic lateral sclerosis. Acta Neurol Scand. 2019 May;139(5):438-44510.1111/ane.1307330712314
  23. 23. Motataianu A, Andone S, Radu C, et al. Predictors of Depression in Caucasian Patients with Amyotrophic Lateral Sclerosis in Romania. Brain Sci. 2020 Jul 22;10(8):47010.3390/brainsci10080470746521532707986
  24. 24. Körner S, Kollewe K, Ilsemann J, et al. Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis. Eur J Neurol. 2013 Apr;20(4):647-5410.1111/ene.1201523094606
  25. 25. Caga J, Turner MR, Hsieh S, et al. Apathy is associated with poor prognosis in amyotrophic lateral sclerosis. Eur J Neurol. 2016 May;23(5):891-710.1111/ene.1295926822417
  26. 26. Koenigs M, Grafman J. The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res. 2009 Aug 12;201(2):239-4310.1016/j.bbr.2009.03.004268078019428640
  27. 27. Mioshi E, Caga J, Lillo P, et al. Neuropsychiatric changes precede classic motor symptoms in ALS and do not affect survival. Neurology. 2014 Jan 14;82(2):149-5510.1212/WNL.000000000000002324336140
  28. 28. Mioshi E, Lillo P, Yew B, et al. Cortical atrophy in ALS is critically associated with neuropsychiatric and cognitive changes. Neurology. 2013 Mar 19;80(12):1117-2310.1212/WNL.0b013e31828869da23427327
  29. 29. Mehl T, Jordan B, Zierz S. “Patients with amyotrophic lateral sclerosis (ALS) are usually nice persons”-How physicians experienced in ALS see the personality characteristics of their patients. Brain Behav. 2016 Nov 10;7(1):e0059910.1002/brb3.599525618228127517
  30. 30. Grossman AB, Levin BE, Bradley WG. Premorbid personality characteristics of patients with ALS. Amyotroph Lateral Scler. 2006 Mar;7(1):27-3110.1080/1466082051001200416546756
DOI: https://doi.org/10.2478/amma-2021-0041 | Journal eISSN: 2668-7763 | Journal ISSN: 2668-7755
Language: English
Page range: 3 - 5
Submitted on: Oct 26, 2021
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Accepted on: Nov 18, 2021
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Published on: Apr 13, 2022
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2022 Anca Moțățăianu, Ioana Ormenișan, Rodica Bălașa, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.