Abstract
In this study the synthesis of three new N-pyrrolyl azomethine derivatives comprising furan, substituted furan and indole residues is presented. A classical Paal-Knorr cyclization was used for synthesis of the initial N-pyrrolyl hydrazine and the final azomethines were obtained in a micro synthesis scale, assuring about 69–76% yields, low harmful emissions and reagent economy. The compounds were elucidated by IR, 1H NMR and 13C NMR spectral analyses and the obtained results were consistent with the assigned structures. The purity of the substances was proven by TLC characteristics and corresponding melting points. In addition, the neurotoxicity and possible MAO-A and MAO-B inhibitory effects were elucidated in vitro. The obtained results indicated that the target molecules are with low neurotoxicity and no MAOA/B enzyme inhibiting effects.