Abstract
Salivary gland swelling can be a challenge for clinicians, and there are various reasons why. Many diseases may affect salivary tissue, and it is important to be familiar with their symptoms and paraclinical findings. Knowing the most common etiologies of multifocal swelling of salivary glands and the precise use of different clinical and paraclinical modalities can improve diagnostic accuracy. The goal of our research is to present a rare clinical case of acute multifocal sialadenitis of major and minor salivary glands of unknown origin and to discuss the differential diagnostic options that can improve timely, accurate treatment and improve the result of the treatment.