Correlation between Interleukin-17, Interleukin-10 Levels, Mean Platelet Volume to Platelet Count Ratio and Apache II Score in Sepsis

Harviendo, G.; Adhipireno, P.; Rachmawati, B.; Limijadi, E.; Retnoningrum, D.

doi:10.2478/amb-2025-0070

Abstract

Background

We used the Acute Physiology and Chronic Health Evaluation II (APACHE II) score to gauge the severity of sepsis. It was based on 12 physiological and laboratory measurements taken in the first 24 hours in the intensive care unit. The severity of sepsis correlates with the pro-inflammatory cytokine interleukin-17 (IL-17) and the anti-inflammatory cytokine interleukin-10. The mean platelet volume to platelet count (MPV/PC) ratio acts as a marker of inflammation in sepsis.

Objective

The aim of this study is to prove the correlation between pro-inflammatory cytokines, anti-inflammatory cytokines, and markers of inflammation with APACHE II scores in septic patients.

Materials and methods

A cross-sectional analytical observational study involving 35 sepsis patients was conducted. The enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of IL-17 and IL-10, and a hematology analyzer was used to determine the MPV/PC ratio. The Pearson and Spearman correlation tests were used to analyze the data.

Results

The mean level of IL-17 was 432.51 ± 355.92 pg/ml, IL-10 was 3.09 ± 1.04 pg/ml, and the MPV/PC ratio was 4.90 ± 2.89. The study found significant correlations between IL-17 levels, IL-10 levels, MPV/PC ratio, and the APACHE II score (r = 0.721, p = 0.00), (r = 0.430, p = 0.01), and (r = 0.408, p = 0.01), respectively.

Conclusion

There was a strong positive correlation between IL-17 levels and APACHE II scores, and a moderate positive correlation between IL-10 levels, MPV/PC ratio, and APACHE II scores.

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